PMID- 25744282
OWN - NLM
STAT- MEDLINE
DCOM- 20160112
LR  - 20220408
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Print)
IS  - 1461-1457 (Linking)
VI  - 18
IP  - 6
DP  - 2015 Mar 5
TI  - Resting-state functional connectivity of antero-medial prefrontal cortex 
      sub-regions in major depression and relationship to emotional intelligence.
LID - pyu112 [pii]
LID - 10.1093/ijnp/pyu112 [doi]
AB  - BACKGROUND: Major depressive disorder has been associated with abnormal 
      resting-state functional connectivity (FC), especially in cognitive processing 
      and emotional regulation networks. Although studies have found abnormal FC in 
      regions of the default mode network (DMN), no study has investigated the FC of 
      specific regions within the anterior DMN based on cytoarchitectonic subdivisions 
      of the antero-medial pre-frontal cortex (PFC). Studies from different areas in 
      the field have shown regions within the anterior DMN to be involved in emotional 
      intelligence. Although abnormalities in this region have been observed in 
      depression, the relationship between the ventromedial PFC (vmPFC) function and 
      emotional intelligence has yet to be investigated in depressed individuals. 
      METHODS: Twenty-one medication-free, non-treatment resistant, depressed patients 
      and 21 healthy controls underwent a resting state functional magnetic resonance 
      imaging session. The participants also completed an ability-based measure of 
      emotional intelligence: the Mayer-Salovey-Caruso Emotional Intelligence Test. FC 
      maps of Brodmann areas (BA) 25, 10 m, 10r, and 10p were created and compared 
      between the two groups. RESULTS: Mixed-effects analyses showed that the more 
      anterior seeds encompassed larger areas of the DMN. Compared to healthy controls, 
      depressed patients had significantly lower connectivity between BA10p and the 
      right insula and between BA25 and the perigenual anterior cingulate cortex. 
      Exploratory analyses showed an association between vmPFC connectivity and 
      emotional intelligence. CONCLUSIONS: These results suggest that individuals with 
      depression have reduced FC between antero-medial PFC regions and regions involved 
      in emotional regulation compared to control subjects. Moreover, vmPFC functional 
      connectivity appears linked to emotional intelligence.
CI  - (c) The Author 2015. Published by Oxford University Press on behalf of CINP.
FAU - Sawaya, Helen
AU  - Sawaya H
AD  - American University of Beirut, Department of Psychiatry, Lebanon (Ms. Sawaya, Dr 
      Chahine, Ms Atoui, and Dr Nahas); Stanford University California (Dr Johnson); 
      Brain Stimulation Laboratory, Psychiatry Department, Medical University of South 
      Carolina, South Carolina (Drs Schmidt, Arana, and George); Ralph H. Johnson VA 
      Medical Center, Charleston, SC (Drs Schmidt and George); CWRU Departments of 
      Psychiatry and Psychology, Cleveland Psychoanalytic Center Ohio (Dr Pincus); 
      Washington State University, Department of Integrative Physiology and 
      Neuroscience Washington (Dr Panksepp).
FAU - Johnson, Kevin
AU  - Johnson K
AD  - American University of Beirut, Department of Psychiatry, Lebanon (Ms. Sawaya, Dr 
      Chahine, Ms Atoui, and Dr Nahas); Stanford University California (Dr Johnson); 
      Brain Stimulation Laboratory, Psychiatry Department, Medical University of South 
      Carolina, South Carolina (Drs Schmidt, Arana, and George); Ralph H. Johnson VA 
      Medical Center, Charleston, SC (Drs Schmidt and George); CWRU Departments of 
      Psychiatry and Psychology, Cleveland Psychoanalytic Center Ohio (Dr Pincus); 
      Washington State University, Department of Integrative Physiology and 
      Neuroscience Washington (Dr Panksepp).
FAU - Schmidt, Matthew
AU  - Schmidt M
AD  - American University of Beirut, Department of Psychiatry, Lebanon (Ms. Sawaya, Dr 
      Chahine, Ms Atoui, and Dr Nahas); Stanford University California (Dr Johnson); 
      Brain Stimulation Laboratory, Psychiatry Department, Medical University of South 
      Carolina, South Carolina (Drs Schmidt, Arana, and George); Ralph H. Johnson VA 
      Medical Center, Charleston, SC (Drs Schmidt and George); CWRU Departments of 
      Psychiatry and Psychology, Cleveland Psychoanalytic Center Ohio (Dr Pincus); 
      Washington State University, Department of Integrative Physiology and 
      Neuroscience Washington (Dr Panksepp).
FAU - Arana, Ashley
AU  - Arana A
AD  - American University of Beirut, Department of Psychiatry, Lebanon (Ms. Sawaya, Dr 
      Chahine, Ms Atoui, and Dr Nahas); Stanford University California (Dr Johnson); 
      Brain Stimulation Laboratory, Psychiatry Department, Medical University of South 
      Carolina, South Carolina (Drs Schmidt, Arana, and George); Ralph H. Johnson VA 
      Medical Center, Charleston, SC (Drs Schmidt and George); CWRU Departments of 
      Psychiatry and Psychology, Cleveland Psychoanalytic Center Ohio (Dr Pincus); 
      Washington State University, Department of Integrative Physiology and 
      Neuroscience Washington (Dr Panksepp).
FAU - Chahine, George
AU  - Chahine G
AD  - American University of Beirut, Department of Psychiatry, Lebanon (Ms. Sawaya, Dr 
      Chahine, Ms Atoui, and Dr Nahas); Stanford University California (Dr Johnson); 
      Brain Stimulation Laboratory, Psychiatry Department, Medical University of South 
      Carolina, South Carolina (Drs Schmidt, Arana, and George); Ralph H. Johnson VA 
      Medical Center, Charleston, SC (Drs Schmidt and George); CWRU Departments of 
      Psychiatry and Psychology, Cleveland Psychoanalytic Center Ohio (Dr Pincus); 
      Washington State University, Department of Integrative Physiology and 
      Neuroscience Washington (Dr Panksepp).
FAU - Atoui, Mia
AU  - Atoui M
AD  - American University of Beirut, Department of Psychiatry, Lebanon (Ms. Sawaya, Dr 
      Chahine, Ms Atoui, and Dr Nahas); Stanford University California (Dr Johnson); 
      Brain Stimulation Laboratory, Psychiatry Department, Medical University of South 
      Carolina, South Carolina (Drs Schmidt, Arana, and George); Ralph H. Johnson VA 
      Medical Center, Charleston, SC (Drs Schmidt and George); CWRU Departments of 
      Psychiatry and Psychology, Cleveland Psychoanalytic Center Ohio (Dr Pincus); 
      Washington State University, Department of Integrative Physiology and 
      Neuroscience Washington (Dr Panksepp).
FAU - Pincus, David
AU  - Pincus D
AD  - American University of Beirut, Department of Psychiatry, Lebanon (Ms. Sawaya, Dr 
      Chahine, Ms Atoui, and Dr Nahas); Stanford University California (Dr Johnson); 
      Brain Stimulation Laboratory, Psychiatry Department, Medical University of South 
      Carolina, South Carolina (Drs Schmidt, Arana, and George); Ralph H. Johnson VA 
      Medical Center, Charleston, SC (Drs Schmidt and George); CWRU Departments of 
      Psychiatry and Psychology, Cleveland Psychoanalytic Center Ohio (Dr Pincus); 
      Washington State University, Department of Integrative Physiology and 
      Neuroscience Washington (Dr Panksepp).
FAU - George, Mark S
AU  - George MS
AD  - American University of Beirut, Department of Psychiatry, Lebanon (Ms. Sawaya, Dr 
      Chahine, Ms Atoui, and Dr Nahas); Stanford University California (Dr Johnson); 
      Brain Stimulation Laboratory, Psychiatry Department, Medical University of South 
      Carolina, South Carolina (Drs Schmidt, Arana, and George); Ralph H. Johnson VA 
      Medical Center, Charleston, SC (Drs Schmidt and George); CWRU Departments of 
      Psychiatry and Psychology, Cleveland Psychoanalytic Center Ohio (Dr Pincus); 
      Washington State University, Department of Integrative Physiology and 
      Neuroscience Washington (Dr Panksepp).
FAU - Panksepp, Jaak
AU  - Panksepp J
AD  - American University of Beirut, Department of Psychiatry, Lebanon (Ms. Sawaya, Dr 
      Chahine, Ms Atoui, and Dr Nahas); Stanford University California (Dr Johnson); 
      Brain Stimulation Laboratory, Psychiatry Department, Medical University of South 
      Carolina, South Carolina (Drs Schmidt, Arana, and George); Ralph H. Johnson VA 
      Medical Center, Charleston, SC (Drs Schmidt and George); CWRU Departments of 
      Psychiatry and Psychology, Cleveland Psychoanalytic Center Ohio (Dr Pincus); 
      Washington State University, Department of Integrative Physiology and 
      Neuroscience Washington (Dr Panksepp).
FAU - Nahas, Ziad
AU  - Nahas Z
AD  - American University of Beirut, Department of Psychiatry, Lebanon (Ms. Sawaya, Dr 
      Chahine, Ms Atoui, and Dr Nahas); Stanford University California (Dr Johnson); 
      Brain Stimulation Laboratory, Psychiatry Department, Medical University of South 
      Carolina, South Carolina (Drs Schmidt, Arana, and George); Ralph H. Johnson VA 
      Medical Center, Charleston, SC (Drs Schmidt and George); CWRU Departments of 
      Psychiatry and Psychology, Cleveland Psychoanalytic Center Ohio (Dr Pincus); 
      Washington State University, Department of Integrative Physiology and 
      Neuroscience Washington (Dr Panksepp). zn17@aub.edu.lb.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150305
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
SB  - IM
MH  - Adult
MH  - Brain Mapping/*methods
MH  - *Brain Waves
MH  - Case-Control Studies
MH  - Depressive Disorder, Major/diagnosis/*physiopathology/psychology
MH  - *Emotional Intelligence
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neural Pathways/physiopathology
MH  - Prefrontal Cortex/*physiopathology
MH  - *Rest
MH  - Young Adult
PMC - PMC4438550
OTO - NOTNLM
OT  - MSCEIT
OT  - anterior medial PFC
OT  - emotional intelligence
OT  - major depression
OT  - resting state functional connectivity
EDAT- 2015/03/07 06:00
MHDA- 2016/01/13 06:00
PMCR- 2015/03/05
CRDT- 2015/03/07 06:00
PHST- 2014/09/18 00:00 [received]
PHST- 2014/12/15 00:00 [accepted]
PHST- 2015/03/07 06:00 [entrez]
PHST- 2015/03/07 06:00 [pubmed]
PHST- 2016/01/13 06:00 [medline]
PHST- 2015/03/05 00:00 [pmc-release]
AID - pyu112 [pii]
AID - 10.1093/ijnp/pyu112 [doi]
PST - epublish
SO  - Int J Neuropsychopharmacol. 2015 Mar 5;18(6):pyu112. doi: 10.1093/ijnp/pyu112.