PMID- 25744676
OWN - NLM
STAT- MEDLINE
DCOM- 20150921
LR  - 20150306
IS  - 1878-0814 (Electronic)
IS  - 1877-1173 (Linking)
VI  - 131
DP  - 2015
TI  - Role of extracellular damage-associated molecular pattern molecules (DAMPs) as 
      mediators of persistent pain.
PG  - 251-79
LID - S1877-1173(14)00029-5 [pii]
LID - 10.1016/bs.pmbts.2014.11.014 [doi]
AB  - Damage-associated molecular pattern molecules (DAMPs) are endogenous molecules 
      that are constitutively expressed and released upon tissue damage, resulting in 
      activation of the immune system. In the absence of injury or infection, DAMPs 
      play important intracellular roles. However, once released subsequent to cell 
      damage or cell stress, DAMPs promote activation of innate immune cells and 
      recruitment and activation of antigen-presenting cells engaged in host defense 
      and tissue repair. This process involves pattern recognition receptors, such as 
      the Toll-like receptors (TLRs) and receptor for advanced glycation end products 
      (RAGE). Several of the TLRs and RAGE have been implicated to play key roles not 
      only in the detection of injury but also in pain signaling. Pain-like behavior is 
      reduced in TLR2- and TLR4-deficient mice, and after injection of TLR2-, TLR4-, 
      and RAGE antagonists in experimental models of nerve injury, arthritis, and bone 
      cancer pain. This suggests that the pathological processes in these models are 
      associated with release of endogenous TLR and RAGE ligands, and further that 
      DAMPs play an important role in persistent pain. There is now a rapidly growing 
      list of DAMPs in the literature and here we give an overview of DAMPs that have 
      been associated with nociceptive signaling.
CI  - (c) 2015 Elsevier Inc. All rights reserved.
FAU - Kato, Jungo
AU  - Kato J
AD  - Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 
      Sweden.
FAU - Svensson, Camilla I
AU  - Svensson CI
AD  - Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 
      Sweden. Electronic address: camilla.svensson@ki.se.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150130
PL  - Netherlands
TA  - Prog Mol Biol Transl Sci
JT  - Progress in molecular biology and translational science
JID - 101498165
RN  - 0 (MicroRNAs)
RN  - 0 (Proteins)
RN  - 0 (Purines)
RN  - 0 (Receptors, Pattern Recognition)
SB  - IM
MH  - Animals
MH  - Extracellular Space/*metabolism
MH  - Humans
MH  - MicroRNAs/metabolism
MH  - Pain/*metabolism
MH  - Proteins/metabolism
MH  - Purines/metabolism
MH  - Receptors, Pattern Recognition/*metabolism
OTO - NOTNLM
OT  - DAMP
OT  - HMGB1
OT  - Heat-shock proteins
OT  - Pain
OT  - S100B
OT  - microRNA
EDAT- 2015/03/07 06:00
MHDA- 2015/09/22 06:00
CRDT- 2015/03/07 06:00
PHST- 2015/03/07 06:00 [entrez]
PHST- 2015/03/07 06:00 [pubmed]
PHST- 2015/09/22 06:00 [medline]
AID - S1877-1173(14)00029-5 [pii]
AID - 10.1016/bs.pmbts.2014.11.014 [doi]
PST - ppublish
SO  - Prog Mol Biol Transl Sci. 2015;131:251-79. doi: 10.1016/bs.pmbts.2014.11.014. 
      Epub 2015 Jan 30.