PMID- 2574478
OWN - NLM
STAT- MEDLINE
DCOM- 19900125
LR  - 20190726
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 99
IP  - 3
DP  - 1989
TI  - MDMA produces stimulant-like conditioned locomotor activity.
PG  - 352-6
AB  - Daily administration of a drug in a distinctive environment establishes 
      contingencies that support Pavlovian conditioning. Environmental cues that are 
      paired with the drug injection and that predict the onset of drug action can 
      become conditioned stimuli. Ultimately, the conditioned stimuli come to predict 
      the availability of drug and develop the potential to engender conditioned drug 
      responses. Various psychostimulant drugs can produce conditioned locomotion when 
      tested in the presence of environmental cues that were repeatedly associated with 
      the drug experience. The ability of amphetamine and cocaine to produce 
      conditioned locomotion was demonstrated in the present study. Stimulant-like 
      properties of methylenedioxy-methamphetamine (MDMA) have been reported in 
      locomotor paradigms, drug discrimination procedures, and human subjective 
      questionnaires. MDMA (5 mg/kg), paired for 5 days to a distinct environment 
      signalled by the presence of a distinct odor, produced enhanced locomotion during 
      a test probe with the odor alone indicating that MDMA can also produce 
      conditioned locomotion. The observation that the stimulus properties of MDMA can 
      also become associated with environmental cues supports the hypothesis that some 
      of the behavioral effects of MDMA resemble those of other classical 
      psychostimulants such as amphetamine and cocaine.
FAU - Gold, L H
AU  - Gold LH
AD  - Department of Basic and Clinical Research, Research Institute of Scripps Clinic, 
      La Jolla, CA 92037.
FAU - Koob, G F
AU  - Koob GF
LA  - eng
GR  - AA 06420/AA/NIAAA NIH HHS/United States
GR  - DA 04398/DA/NIDA NIH HHS/United States
GR  - DA 05333/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Amphetamines)
RN  - 0 (Central Nervous System Stimulants)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - CK833KGX7E (Amphetamine)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
MH  - Amphetamine/pharmacology
MH  - Amphetamines/*pharmacology
MH  - Animals
MH  - *Central Nervous System Stimulants
MH  - Cocaine/pharmacology
MH  - Conditioning, Operant/*drug effects
MH  - Male
MH  - Motor Activity/*drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.1007/BF00445556 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 1989;99(3):352-6. doi: 10.1007/BF00445556.