PMID- 25744839
OWN - NLM
STAT- MEDLINE
DCOM- 20150702
LR  - 20181202
IS  - 1007-8738 (Print)
IS  - 1007-8738 (Linking)
VI  - 31
IP  - 3
DP  - 2015 Mar
TI  - [Intermittent hypoxia promotes the expressions of rat hippocampal neuronal 
      hypoxia-inducible factor-1 and survivin].
PG  - 338-41
AB  - OBJECTIVE: To establish an intermittent hypoxia (IH) animal model by simulating 
      the features of obstructive sleep apnea-hypopnea syndrome and observe the 
      expressions of hypoxia-inducible factor-1 (HIF-1) and survivin and the occurrence 
      of apoptosis in the hippocampal CA1 neuron of rats with early IH. METHODS: Male 
      Wistar rats (n=72) were randomly divided into control group and IH group. In 
      control group, rats were given compressed air and in IH group, rats were exposed 
      to 50 mL/L IH for 7 hours a day, lasting 3, 7, 14 and 21 days, respectively. The 
      expressions of HIF-1 and survivin in hippocampal CA1 were detected by 
      immunohistochemistry and the neuronal apoptosis index was calculated by TUNEL. 
      RESULTS: Compared with control group, apoptosis index in the third day of 5% IH 
      group had no significant difference, while apoptosis index in IH 7-, 14- and 
      21-day groups were significantly higher than that in control group, and on the 
      21st day it reached a peak. The expressions of HIF-1 and survivin protein in 5% 
      IH group significantly increased as compared with control group at each time 
      point, and they peaked on the 14th day, then decreased gradually. There was a 
      positive relationship between the expressions of HIF-1 and survivin. CONCLUSION: 
      Early IH can induce HIF-1 and survivin protein expressions in rat hippocampal 
      CA1, and their expressions may play an important role in the regulation of 
      neuronal apoptosis.
FAU - Wang, Ling
AU  - Wang L
AD  - Department of Respiratory Medicine, Hospital Affiliated to Hebei United 
      University, Tangshan 063000, China.
FAU - Zhang, Panpan
AU  - Zhang P
AD  - Department of Respiratory Medicine, Hospital Affiliated to Hebei United 
      University, Tangshan 063000, China.
FAU - Wang, Hongyang
AU  - Wang H
AD  - Department of Respiratory Medicine, Hospital Affiliated to Hebei United 
      University, Tangshan 063000, China.
FAU - Yu, Jiangtao
AU  - Yu J
AD  - Department of Respiratory Medicine, Hospital Affiliated to Hebei United 
      University, Tangshan 063000, China.
FAU - Zhang, Min
AU  - Zhang M
AD  - Department of Respiratory Medicine, Hospital Affiliated to Hebei United 
      University, Tangshan 063000, China.
FAU - Han, Xiaoqing
AU  - Han X
AD  - Department of Respiratory Medicine, Hospital Affiliated to Hebei United 
      University, Tangshan 063000, China.
FAU - Li, Lin
AU  - Li L
AD  - Department of Respiratory Medicine, Hospital Affiliated to Hebei United 
      University, Tangshan 063000, China.
FAU - Liu, Chen
AU  - Liu C
AD  - Department of Respiratory Medicine, Hospital Affiliated to Hebei United 
      University, Tangshan 063000, China.
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
JT  - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular 
      immunology
JID - 101139110
RN  - 0 (Birc5 protein, rat)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Survivin)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Hippocampus/cytology/*metabolism
MH  - Humans
MH  - Hypoxia/*genetics/metabolism/physiopathology
MH  - Hypoxia-Inducible Factor 1/*genetics/metabolism
MH  - Male
MH  - Microtubule-Associated Proteins/*genetics/metabolism
MH  - Neurons/cytology/*metabolism
MH  - Oxygen/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Sleep Apnea, Obstructive/*genetics/metabolism/physiopathology
MH  - Survivin
MH  - Up-Regulation
EDAT- 2015/03/07 06:00
MHDA- 2015/07/03 06:00
CRDT- 2015/03/07 06:00
PHST- 2015/03/07 06:00 [entrez]
PHST- 2015/03/07 06:00 [pubmed]
PHST- 2015/07/03 06:00 [medline]
PST - ppublish
SO  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015 Mar;31(3):338-41.