PMID- 25745134
OWN - NLM
STAT- MEDLINE
DCOM- 20160204
LR  - 20210109
IS  - 1472-1465 (Electronic)
IS  - 0007-1250 (Print)
IS  - 0007-1250 (Linking)
VI  - 206
IP  - 5
DP  - 2015 May
TI  - Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on 
      prefrontal regions in major depressive disorder.
PG  - 379-84
LID - 10.1192/bjp.bp.113.143529 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism 
      contributes to the development of depression (major depressive disorder, MDD), 
      but it is unclear whether neural effects observed in healthy individuals are 
      sustained in MDD. AIMS: To investigate BDNF Val66Met effects on key regions in 
      MDD neurocircuitry: amygdala, anterior cingulate, middle frontal and 
      orbitofrontal regions. METHOD: Magnetic resonance imaging scans were acquired in 
      79 persons with MDD (mean age 49 years) and 74 healthy volunteers (mean age 50 
      years). Effects on surface area and cortical thickness were examined with 
      multiple comparison correction. RESULTS: People who were Met allele carriers 
      showed reduced caudal middle frontal thickness in both study groups. Significant 
      interaction effects were found in the anterior cingulate and rostral middle 
      frontal regions, in which participants in the MDD group who were Met carriers 
      showed the greatest reduction in surface area. CONCLUSIONS: Modulatory effects of 
      the BDNF Val66Met polymorphism on distinct subregions in the prefrontal cortex in 
      MDD support the neurotrophin model of depression.
CI  - (c) The Royal College of Psychiatrists 2015.
FAU - Legge, Rebecca MacGregor
AU  - Legge RM
AD  - Rebecca MacGregor Legge, MSc, Shahbaz Sendi, MD, Department of Psychological 
      Medicine, Institute of Psychiatry, King's College London; James H. Cole, PhD, 
      Computational, Cognitive and Clinical Neuroimaging Laboratory, Department of 
      Medicine, Imperial College London, UK; Sarah Cohen-Woods, PhD, Discipline of 
      Psychiatry, School of Medicine, University of Adelaide, Adelaide, Australia; 
      Sergi G. Costafreda, MD, PhD, Department of Old Age Psychiatry, Institute of 
      Psychiatry, King's College London; Andrew Simmons, PhD, Department of 
      Neuroimaging, Institute of Psychiatry, National Institute of Health Research 
      (NIHR) Biomedical Research Centre for Mental Health at South London and 
      Department of Old Age Psychiatry, Institute of Psychiatry, King's College London; 
      Anne E. Farmer, MD, FRCPsych, Medical Research Council (MRC) Social, Genetic and 
      Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College 
      London, UK; Katherine J. Aitchison, PhD, MRCPsych, Department of Psychiatry, 
      University of Alberta, Edmonton, Canada; Peter McGuffin, PhD, FMedSci, NIHR 
      Biomedical Research Centre for Mental Health at South London and Department of 
      Old Age Psychiatry, Institute of Psychiatry, MRC Social, Genetic and 
      Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College 
      London; Cynthia H.Y. Fu, MD, PhD, Department of Psychological Medicine, Institute 
      of Psychiatry, King's College London, and School of Psychology, University of 
      East London, London, UK.
FAU - Sendi, Shahbaz
AU  - Sendi S
AD  - Rebecca MacGregor Legge, MSc, Shahbaz Sendi, MD, Department of Psychological 
      Medicine, Institute of Psychiatry, King's College London; James H. Cole, PhD, 
      Computational, Cognitive and Clinical Neuroimaging Laboratory, Department of 
      Medicine, Imperial College London, UK; Sarah Cohen-Woods, PhD, Discipline of 
      Psychiatry, School of Medicine, University of Adelaide, Adelaide, Australia; 
      Sergi G. Costafreda, MD, PhD, Department of Old Age Psychiatry, Institute of 
      Psychiatry, King's College London; Andrew Simmons, PhD, Department of 
      Neuroimaging, Institute of Psychiatry, National Institute of Health Research 
      (NIHR) Biomedical Research Centre for Mental Health at South London and 
      Department of Old Age Psychiatry, Institute of Psychiatry, King's College London; 
      Anne E. Farmer, MD, FRCPsych, Medical Research Council (MRC) Social, Genetic and 
      Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College 
      London, UK; Katherine J. Aitchison, PhD, MRCPsych, Department of Psychiatry, 
      University of Alberta, Edmonton, Canada; Peter McGuffin, PhD, FMedSci, NIHR 
      Biomedical Research Centre for Mental Health at South London and Department of 
      Old Age Psychiatry, Institute of Psychiatry, MRC Social, Genetic and 
      Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College 
      London; Cynthia H.Y. Fu, MD, PhD, Department of Psychological Medicine, Institute 
      of Psychiatry, King's College London, and School of Psychology, University of 
      East London, London, UK.
FAU - Cole, James H
AU  - Cole JH
AD  - Rebecca MacGregor Legge, MSc, Shahbaz Sendi, MD, Department of Psychological 
      Medicine, Institute of Psychiatry, King's College London; James H. Cole, PhD, 
      Computational, Cognitive and Clinical Neuroimaging Laboratory, Department of 
      Medicine, Imperial College London, UK; Sarah Cohen-Woods, PhD, Discipline of 
      Psychiatry, School of Medicine, University of Adelaide, Adelaide, Australia; 
      Sergi G. Costafreda, MD, PhD, Department of Old Age Psychiatry, Institute of 
      Psychiatry, King's College London; Andrew Simmons, PhD, Department of 
      Neuroimaging, Institute of Psychiatry, National Institute of Health Research 
      (NIHR) Biomedical Research Centre for Mental Health at South London and 
      Department of Old Age Psychiatry, Institute of Psychiatry, King's College London; 
      Anne E. Farmer, MD, FRCPsych, Medical Research Council (MRC) Social, Genetic and 
      Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College 
      London, UK; Katherine J. Aitchison, PhD, MRCPsych, Department of Psychiatry, 
      University of Alberta, Edmonton, Canada; Peter McGuffin, PhD, FMedSci, NIHR 
      Biomedical Research Centre for Mental Health at South London and Department of 
      Old Age Psychiatry, Institute of Psychiatry, MRC Social, Genetic and 
      Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College 
      London; Cynthia H.Y. Fu, MD, PhD, Department of Psychological Medicine, Institute 
      of Psychiatry, King's College London, and School of Psychology, University of 
      East London, London, UK.
FAU - Cohen-Woods, Sarah
AU  - Cohen-Woods S
AD  - Rebecca MacGregor Legge, MSc, Shahbaz Sendi, MD, Department of Psychological 
      Medicine, Institute of Psychiatry, King's College London; James H. Cole, PhD, 
      Computational, Cognitive and Clinical Neuroimaging Laboratory, Department of 
      Medicine, Imperial College London, UK; Sarah Cohen-Woods, PhD, Discipline of 
      Psychiatry, School of Medicine, University of Adelaide, Adelaide, Australia; 
      Sergi G. Costafreda, MD, PhD, Department of Old Age Psychiatry, Institute of 
      Psychiatry, King's College London; Andrew Simmons, PhD, Department of 
      Neuroimaging, Institute of Psychiatry, National Institute of Health Research 
      (NIHR) Biomedical Research Centre for Mental Health at South London and 
      Department of Old Age Psychiatry, Institute of Psychiatry, King's College London; 
      Anne E. Farmer, MD, FRCPsych, Medical Research Council (MRC) Social, Genetic and 
      Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College 
      London, UK; Katherine J. Aitchison, PhD, MRCPsych, Department of Psychiatry, 
      University of Alberta, Edmonton, Canada; Peter McGuffin, PhD, FMedSci, NIHR 
      Biomedical Research Centre for Mental Health at South London and Department of 
      Old Age Psychiatry, Institute of Psychiatry, MRC Social, Genetic and 
      Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College 
      London; Cynthia H.Y. Fu, MD, PhD, Department of Psychological Medicine, Institute 
      of Psychiatry, King's College London, and School of Psychology, University of 
      East London, London, UK.
FAU - Costafreda, Sergi G
AU  - Costafreda SG
AD  - Rebecca MacGregor Legge, MSc, Shahbaz Sendi, MD, Department of Psychological 
      Medicine, Institute of Psychiatry, King's College London; James H. Cole, PhD, 
      Computational, Cognitive and Clinical Neuroimaging Laboratory, Department of 
      Medicine, Imperial College London, UK; Sarah Cohen-Woods, PhD, Discipline of 
      Psychiatry, School of Medicine, University of Adelaide, Adelaide, Australia; 
      Sergi G. Costafreda, MD, PhD, Department of Old Age Psychiatry, Institute of 
      Psychiatry, King's College London; Andrew Simmons, PhD, Department of 
      Neuroimaging, Institute of Psychiatry, National Institute of Health Research 
      (NIHR) Biomedical Research Centre for Mental Health at South London and 
      Department of Old Age Psychiatry, Institute of Psychiatry, King's College London; 
      Anne E. Farmer, MD, FRCPsych, Medical Research Council (MRC) Social, Genetic and 
      Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College 
      London, UK; Katherine J. Aitchison, PhD, MRCPsych, Department of Psychiatry, 
      University of Alberta, Edmonton, Canada; Peter McGuffin, PhD, FMedSci, NIHR 
      Biomedical Research Centre for Mental Health at South London and Department of 
      Old Age Psychiatry, Institute of Psychiatry, MRC Social, Genetic and 
      Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College 
      London; Cynthia H.Y. Fu, MD, PhD, Department of Psychological Medicine, Institute 
      of Psychiatry, King's College London, and School of Psychology, University of 
      East London, London, UK.
FAU - Simmons, Andrew
AU  - Simmons A
AD  - Rebecca MacGregor Legge, MSc, Shahbaz Sendi, MD, Department of Psychological 
      Medicine, Institute of Psychiatry, King's College London; James H. Cole, PhD, 
      Computational, Cognitive and Clinical Neuroimaging Laboratory, Department of 
      Medicine, Imperial College London, UK; Sarah Cohen-Woods, PhD, Discipline of 
      Psychiatry, School of Medicine, University of Adelaide, Adelaide, Australia; 
      Sergi G. Costafreda, MD, PhD, Department of Old Age Psychiatry, Institute of 
      Psychiatry, King's College London; Andrew Simmons, PhD, Department of 
      Neuroimaging, Institute of Psychiatry, National Institute of Health Research 
      (NIHR) Biomedical Research Centre for Mental Health at South London and 
      Department of Old Age Psychiatry, Institute of Psychiatry, King's College London; 
      Anne E. Farmer, MD, FRCPsych, Medical Research Council (MRC) Social, Genetic and 
      Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College 
      London, UK; Katherine J. Aitchison, PhD, MRCPsych, Department of Psychiatry, 
      University of Alberta, Edmonton, Canada; Peter McGuffin, PhD, FMedSci, NIHR 
      Biomedical Research Centre for Mental Health at South London and Department of 
      Old Age Psychiatry, Institute of Psychiatry, MRC Social, Genetic and 
      Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College 
      London; Cynthia H.Y. Fu, MD, PhD, Department of Psychological Medicine, Institute 
      of Psychiatry, King's College London, and School of Psychology, University of 
      East London, London, UK.
FAU - Farmer, Anne E
AU  - Farmer AE
AD  - Rebecca MacGregor Legge, MSc, Shahbaz Sendi, MD, Department of Psychological 
      Medicine, Institute of Psychiatry, King's College London; James H. Cole, PhD, 
      Computational, Cognitive and Clinical Neuroimaging Laboratory, Department of 
      Medicine, Imperial College London, UK; Sarah Cohen-Woods, PhD, Discipline of 
      Psychiatry, School of Medicine, University of Adelaide, Adelaide, Australia; 
      Sergi G. Costafreda, MD, PhD, Department of Old Age Psychiatry, Institute of 
      Psychiatry, King's College London; Andrew Simmons, PhD, Department of 
      Neuroimaging, Institute of Psychiatry, National Institute of Health Research 
      (NIHR) Biomedical Research Centre for Mental Health at South London and 
      Department of Old Age Psychiatry, Institute of Psychiatry, King's College London; 
      Anne E. Farmer, MD, FRCPsych, Medical Research Council (MRC) Social, Genetic and 
      Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College 
      London, UK; Katherine J. Aitchison, PhD, MRCPsych, Department of Psychiatry, 
      University of Alberta, Edmonton, Canada; Peter McGuffin, PhD, FMedSci, NIHR 
      Biomedical Research Centre for Mental Health at South London and Department of 
      Old Age Psychiatry, Institute of Psychiatry, MRC Social, Genetic and 
      Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College 
      London; Cynthia H.Y. Fu, MD, PhD, Department of Psychological Medicine, Institute 
      of Psychiatry, King's College London, and School of Psychology, University of 
      East London, London, UK.
FAU - Aitchison, Katherine J
AU  - Aitchison KJ
AD  - Rebecca MacGregor Legge, MSc, Shahbaz Sendi, MD, Department of Psychological 
      Medicine, Institute of Psychiatry, King's College London; James H. Cole, PhD, 
      Computational, Cognitive and Clinical Neuroimaging Laboratory, Department of 
      Medicine, Imperial College London, UK; Sarah Cohen-Woods, PhD, Discipline of 
      Psychiatry, School of Medicine, University of Adelaide, Adelaide, Australia; 
      Sergi G. Costafreda, MD, PhD, Department of Old Age Psychiatry, Institute of 
      Psychiatry, King's College London; Andrew Simmons, PhD, Department of 
      Neuroimaging, Institute of Psychiatry, National Institute of Health Research 
      (NIHR) Biomedical Research Centre for Mental Health at South London and 
      Department of Old Age Psychiatry, Institute of Psychiatry, King's College London; 
      Anne E. Farmer, MD, FRCPsych, Medical Research Council (MRC) Social, Genetic and 
      Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College 
      London, UK; Katherine J. Aitchison, PhD, MRCPsych, Department of Psychiatry, 
      University of Alberta, Edmonton, Canada; Peter McGuffin, PhD, FMedSci, NIHR 
      Biomedical Research Centre for Mental Health at South London and Department of 
      Old Age Psychiatry, Institute of Psychiatry, MRC Social, Genetic and 
      Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College 
      London; Cynthia H.Y. Fu, MD, PhD, Department of Psychological Medicine, Institute 
      of Psychiatry, King's College London, and School of Psychology, University of 
      East London, London, UK.
FAU - McGuffin, Peter
AU  - McGuffin P
AD  - Rebecca MacGregor Legge, MSc, Shahbaz Sendi, MD, Department of Psychological 
      Medicine, Institute of Psychiatry, King's College London; James H. Cole, PhD, 
      Computational, Cognitive and Clinical Neuroimaging Laboratory, Department of 
      Medicine, Imperial College London, UK; Sarah Cohen-Woods, PhD, Discipline of 
      Psychiatry, School of Medicine, University of Adelaide, Adelaide, Australia; 
      Sergi G. Costafreda, MD, PhD, Department of Old Age Psychiatry, Institute of 
      Psychiatry, King's College London; Andrew Simmons, PhD, Department of 
      Neuroimaging, Institute of Psychiatry, National Institute of Health Research 
      (NIHR) Biomedical Research Centre for Mental Health at South London and 
      Department of Old Age Psychiatry, Institute of Psychiatry, King's College London; 
      Anne E. Farmer, MD, FRCPsych, Medical Research Council (MRC) Social, Genetic and 
      Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College 
      London, UK; Katherine J. Aitchison, PhD, MRCPsych, Department of Psychiatry, 
      University of Alberta, Edmonton, Canada; Peter McGuffin, PhD, FMedSci, NIHR 
      Biomedical Research Centre for Mental Health at South London and Department of 
      Old Age Psychiatry, Institute of Psychiatry, MRC Social, Genetic and 
      Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College 
      London; Cynthia H.Y. Fu, MD, PhD, Department of Psychological Medicine, Institute 
      of Psychiatry, King's College London, and School of Psychology, University of 
      East London, London, UK.
FAU - Fu, Cynthia H Y
AU  - Fu CH
AD  - Rebecca MacGregor Legge, MSc, Shahbaz Sendi, MD, Department of Psychological 
      Medicine, Institute of Psychiatry, King's College London; James H. Cole, PhD, 
      Computational, Cognitive and Clinical Neuroimaging Laboratory, Department of 
      Medicine, Imperial College London, UK; Sarah Cohen-Woods, PhD, Discipline of 
      Psychiatry, School of Medicine, University of Adelaide, Adelaide, Australia; 
      Sergi G. Costafreda, MD, PhD, Department of Old Age Psychiatry, Institute of 
      Psychiatry, King's College London; Andrew Simmons, PhD, Department of 
      Neuroimaging, Institute of Psychiatry, National Institute of Health Research 
      (NIHR) Biomedical Research Centre for Mental Health at South London and 
      Department of Old Age Psychiatry, Institute of Psychiatry, King's College London; 
      Anne E. Farmer, MD, FRCPsych, Medical Research Council (MRC) Social, Genetic and 
      Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College 
      London, UK; Katherine J. Aitchison, PhD, MRCPsych, Department of Psychiatry, 
      University of Alberta, Edmonton, Canada; Peter McGuffin, PhD, FMedSci, NIHR 
      Biomedical Research Centre for Mental Health at South London and Department of 
      Old Age Psychiatry, Institute of Psychiatry, MRC Social, Genetic and 
      Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College 
      London; Cynthia H.Y. Fu, MD, PhD, Department of Psychological Medicine, Institute 
      of Psychiatry, King's College London, and School of Psychology, University of 
      East London, London, UK.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150305
PL  - England
TA  - Br J Psychiatry
JT  - The British journal of psychiatry : the journal of mental science
JID - 0342367
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
CIN - Br J Psychiatry. 2015 Oct;207(4):363. PMID: 26429688
CIN - Br J Psychiatry. 2015 Oct;207(4):363-4. PMID: 26429689
MH  - Adult
MH  - Alleles
MH  - Brain/*physiopathology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Depressive Disorder, Major/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
PMC - PMC4416135
COIS- Declaration of interest None.
EDAT- 2015/03/07 06:00
MHDA- 2016/02/05 06:00
PMCR- 2015/05/01
CRDT- 2015/03/07 06:00
PHST- 2013/12/16 00:00 [received]
PHST- 2014/09/24 00:00 [accepted]
PHST- 2015/03/07 06:00 [entrez]
PHST- 2015/03/07 06:00 [pubmed]
PHST- 2016/02/05 06:00 [medline]
PHST- 2015/05/01 00:00 [pmc-release]
AID - S000712500023821X [pii]
AID - 10.1192/bjp.bp.113.143529 [doi]
PST - ppublish
SO  - Br J Psychiatry. 2015 May;206(5):379-84. doi: 10.1192/bjp.bp.113.143529. Epub 
      2015 Mar 5.