PMID- 25745795
OWN - NLM
STAT- MEDLINE
DCOM- 20150702
LR  - 20151119
IS  - 1532-8171 (Electronic)
IS  - 0735-6757 (Linking)
VI  - 33
IP  - 4
DP  - 2015 Apr
TI  - The relationship between vascular inflammation and target organ damage in 
      hypertensive crises.
PG  - 497-500
LID - S0735-6757(14)00828-6 [pii]
LID - 10.1016/j.ajem.2014.11.014 [doi]
AB  - OBJECTIVE: Hypertensive crises, divided depending on the presence of target organ 
      damage (TOD), are associated with increased cardiovascular mortality and 
      morbidity. Monocyte chemoattractant protein-1 (MCP-1) is responsible for the 
      recruitment of monocytes to sites of vascular inflammation. The aim of this study 
      was to evaluate the role of vascular inflammation in development of TOD. METHOD: 
      The patients were categorized according to the presence of TOD. Thirty-three 
      patients (15 female; mean age, 68 +/- 12 y) with TOD and 30 patients (14 female; 
      mean age, 64 +/- 12 y) without TOD were included to the study. In addition to 
      routine laboratory parameters, neutrophil-lymphocyte ratio, uric acid, C-reactive 
      protein (CRP), high sensitive CRP, and plasma MCP-1 levels were evaluated. 
      RESULTS: Neutrophil counts, white blood cells, high sensitive CRP, and uric acid 
      levels were higher in patients with hypertensive crises. More importantly, CRP 
      (7.2 mg/dL [2-37.8 mg/dL] vs 4.6 mg/dL [1.5-14 mg/dL] vs 2.7 mg/dL [1-8.1 mg/dL], 
      P < .01) and MCP-1 levels (546 pg/mL [236-1350 pg/mL] vs 407 pg/mL [78-942 pg/mL] 
      vs 264 pg/mL [34-579 pg/mL], P < .01) were higher in the group with TOD compared 
      with other groups. CONCLUSION: In conclusion, plasma MCP-1 levels were 
      significantly higher in patients with TOD. According to our results, we suggest 
      that increased vascular inflammation and MCP-1 levels might be associated with 
      the development of TOD in hypertensive crisis.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Karabacak, Mustafa
AU  - Karabacak M
AD  - Department of Cardiology, Isparta State Hospital, Isparta, Turkey. Electronic 
      address: drmustafa1979@hotmail.com.
FAU - Yigit, Mehmet
AU  - Yigit M
AD  - Department of Emergency Medicine, Bezimialem Foundation University, Istanbul, 
      Turkey.
FAU - Turkdogan, Kenan Ahmet
AU  - Turkdogan KA
AD  - Department of Emergency Medicine, Bezimialem Foundation University, Istanbul, 
      Turkey.
FAU - Sert, Mehmet
AU  - Sert M
AD  - Department of Nephrology, Isparta State Hospital, Isparta, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20141120
PL  - United States
TA  - Am J Emerg Med
JT  - The American journal of emergency medicine
JID - 8309942
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 268B43MJ25 (Uric Acid)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Biomarkers/*blood
MH  - C-Reactive Protein/analysis
MH  - Cardiovascular Diseases/*blood/*etiology
MH  - Chemokine CCL2/blood
MH  - Emergency Service, Hospital
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Hypertension/*blood/*complications
MH  - Inflammation/blood/complications
MH  - Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Uric Acid/blood
EDAT- 2015/03/10 06:00
MHDA- 2015/07/03 06:00
CRDT- 2015/03/10 06:00
PHST- 2014/10/02 00:00 [received]
PHST- 2014/11/08 00:00 [revised]
PHST- 2014/11/09 00:00 [accepted]
PHST- 2015/03/10 06:00 [entrez]
PHST- 2015/03/10 06:00 [pubmed]
PHST- 2015/07/03 06:00 [medline]
AID - S0735-6757(14)00828-6 [pii]
AID - 10.1016/j.ajem.2014.11.014 [doi]
PST - ppublish
SO  - Am J Emerg Med. 2015 Apr;33(4):497-500. doi: 10.1016/j.ajem.2014.11.014. Epub 
      2014 Nov 20.