PMID- 25746550
OWN - NLM
STAT- MEDLINE
DCOM- 20151130
LR  - 20150309
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 79
IP  - 3
DP  - 2015
TI  - Cardiac resynchronization therapy for various systemic ventricular morphologies 
      in patients with congenital heart disease.
PG  - 649-55
LID - 10.1253/circj.CJ-14-0395 [doi]
AB  - BACKGROUND: Cardiac resynchronization therapy (CRT) can result in functional 
      improvement and reduced mortality in patients with medically refractory heart 
      failure. Although CRT is reportedly effective in patients with congenital heart 
      disease (CHD), it is still controversial in patients who have systemic right 
      ventricle. METHODS AND RESULTS: Twenty CHD patients treated with CRT since 2006 
      were divided into 3 groups based on systemic ventricular (sysV) morphology (7 
      with left ventricle [sLV], 7 with right ventricle [sRV], and 6 with unbalanced 2 
      ventricles as a single-ventricular physiology [sBV]). The acute effects of CRT on 
      hemodynamics and sysV function before device implantation was retrospectively 
      evaluated and the chronic (>/=6 months) effects of CRT on late outcomes was 
      assessed. In our CHD populations, sysV volume index was reduced from 139+/-41 to 
      118+/-33 ml/m(2)(P=0.04) after CRT, and there was significant improvement in B-type 
      natriuretic peptide levels (from 341+/-384 to 160+/-152 pg/ml, P=0.01) and New York 
      Heart Association (NYHA) functional class (from 2.1+/-0.6 to 1.8+/-0.7, P=0.02) on a 
      late outcome. The sRV group did not show a late sysV volume reduction despite 
      significant QRS shortening, and an increase of sysV peak dP/dt in the acute study 
      differed from that of other groups. CONCLUSIONS: CRT improves late hemodynamic 
      and functional status in sLV and sBV CHD patients with a dyssynchronized sysV. 
      However, an acute CRT effect cannot guarantee long-term benefit in sRV patients.
FAU - Sakaguchi, Heima
AU  - Sakaguchi H
AD  - Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center.
FAU - Miyazaki, Aya
AU  - Miyazaki A
FAU - Yamada, Osamu
AU  - Yamada O
FAU - Kagisaki, Koji
AU  - Kagisaki K
FAU - Hoashi, Takaya
AU  - Hoashi T
FAU - Ichikawa, Hajime
AU  - Ichikawa H
FAU - Ohuchi, Hideo
AU  - Ohuchi H
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150109
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
SB  - IM
CIN - Circ J. 2015;79(3):519-21. PMID: 25746533
MH  - Adolescent
MH  - Adult
MH  - *Cardiac Resynchronization Therapy
MH  - Cardiac Resynchronization Therapy Devices
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - *Heart Defects, Congenital/pathology/physiopathology/therapy
MH  - *Heart Ventricles/pathology/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2015/03/10 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/03/10 06:00
PHST- 2015/03/10 06:00 [entrez]
PHST- 2015/03/10 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1253/circj.CJ-14-0395 [doi]
PST - ppublish
SO  - Circ J. 2015;79(3):649-55. doi: 10.1253/circj.CJ-14-0395. Epub 2015 Jan 9.