PMID- 25746842
OWN - NLM
STAT- MEDLINE
DCOM- 20170315
LR  - 20230918
IS  - 1549-7852 (Electronic)
IS  - 1040-8398 (Linking)
VI  - 57
IP  - 5
DP  - 2017 Mar 24
TI  - Nutritional intervention and impact of polyphenol on glycohemoglobin (HbA1c) in 
      non-diabetic and type 2 diabetic subjects: Systematic review and meta-analysis.
PG  - 975-986
LID - 10.1080/10408398.2014.973932 [doi]
AB  - Polyphenols have been extensively studied for their antioxidant and 
      anti-inflammatory properties. Recently, their antiglycative actions by oxidative 
      stress modulation have been linked to the prevention of diabetes and associated 
      complications. This article assesses the evidence for polyphenol interventions on 
      glycohemoglobin (HbA1c) in non-diabetic, pre-diabetic, and type 2 diabetes 
      mellitus (T2DM) subjects. A systematic review of polyphenols' clinical trials on 
      HbA1c in humans was performed according to the Preferred Reporting Items for 
      Systematic Review and Meta-Analysis. Thirty-six controlled randomized trials with 
      HbA1c values were included. Polyphenols (extracts, supplements, and foods) were 
      supplemented (28 mg to 1.5 g) for 0.7 to 12 months. Combining all subjects (n = 
      1954, mean baseline HbA1c = 7.03%, 53 mmol/mol), polyphenol supplementation 
      significantly (P < 0.001) lowered HbA1c% by -0.53 +/- 0.12 units (-5.79 +/- 
      0.13 mmol/mol). This reduction was significant (P < 0.001) in T2DM subjects, 
      specifically (n = 1426, mean baseline HbA1c = 7.44%, 58 mmol/mol), with HbA1c% 
      lowered by -0.21 +/- 0.04 units (-2.29 +/- 0.4 mmol/mol). Polyphenol supplementation 
      had no significant effect (P > 0.21) in the non-diabetic (n = 258, mean baseline 
      HbA1c = 5.47%, 36 mmol/mol) and the pre-diabetic subjects (n = 270, mean baseline 
      HbA1c = 6.06%, 43 mmol/mol) strata: -0.39 +/- 0.27 HbA1c% units (-4.3 +/- 
      0.3 mmol/mol), and -0.38 +/- 0.31 units (-4.2 +/- 0.31 mmol/mol), respectively. In 
      conclusion, polyphenols can successfully reduce HbA1c in T2DM without any 
      intervention at glycemia, and could contribute to the prevention of diabetes 
      complications.
FAU - Palma-Duran, Susana A
AU  - Palma-Duran SA
AD  - a Department of Human Nutrition , School of Medicine, College of Medical, 
      Veterinary and Life Sciences, University of Glasgow , Glasgow , UK.
FAU - Vlassopoulos, Antonis
AU  - Vlassopoulos A
AD  - a Department of Human Nutrition , School of Medicine, College of Medical, 
      Veterinary and Life Sciences, University of Glasgow , Glasgow , UK.
FAU - Lean, Mike
AU  - Lean M
AD  - a Department of Human Nutrition , School of Medicine, College of Medical, 
      Veterinary and Life Sciences, University of Glasgow , Glasgow , UK.
FAU - Govan, Lindsay
AU  - Govan L
AD  - b Department of Public Health and Health Economics and Health Technology 
      Assessment , University of Glasgow , Glasgow , UK.
FAU - Combet, Emilie
AU  - Combet E
AD  - a Department of Human Nutrition , School of Medicine, College of Medical, 
      Veterinary and Life Sciences, University of Glasgow , Glasgow , UK.
LA  - eng
GR  - MR/J012459/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
PL  - United States
TA  - Crit Rev Food Sci Nutr
JT  - Critical reviews in food science and nutrition
JID - 8914818
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Polyphenols)
SB  - IM
MH  - Anti-Inflammatory Agents/pharmacology
MH  - Antioxidants/pharmacology
MH  - Blood Glucose/metabolism
MH  - Diabetes Complications/prevention & control
MH  - Diabetes Mellitus, Type 2/blood/*drug therapy
MH  - Dietary Supplements
MH  - Glycated Hemoglobin/*metabolism
MH  - Humans
MH  - Polyphenols/*administration & dosage
MH  - Randomized Controlled Trials as Topic
OTO - NOTNLM
OT  - Glycation
OT  - antioxidant
OT  - meta-analysis
OT  - nutrition
OT  - polyphenols
OT  - supplementation
EDAT- 2015/03/10 06:00
MHDA- 2017/03/16 06:00
CRDT- 2015/03/10 06:00
PHST- 2015/03/10 06:00 [pubmed]
PHST- 2017/03/16 06:00 [medline]
PHST- 2015/03/10 06:00 [entrez]
AID - 10.1080/10408398.2014.973932 [doi]
PST - ppublish
SO  - Crit Rev Food Sci Nutr. 2017 Mar 24;57(5):975-986. doi: 
      10.1080/10408398.2014.973932.