PMID- 25748044
OWN - NLM
STAT- MEDLINE
DCOM- 20170601
LR  - 20170601
IS  - 1578-147X (Electronic)
IS  - 0009-739X (Linking)
VI  - 93
IP  - 6
DP  - 2015 Jun-Jul
TI  - [Surgery for gastrinoma: Short and long-term results].
PG  - 390-5
LID - S0009-739X(14)00345-5 [pii]
LID - 10.1016/j.ciresp.2014.10.016 [doi]
AB  - INTRODUCTION: Zollinger-Ellison syndrome (Z-E) is characterized by 
      gastrin-secreting tumors, responsible for causing refractory and recurrent peptic 
      ulcers in the gastrointestinal tract. The optimal approach and the extension of 
      tumor resection remains the subject of debate. METHODS: During the period 
      February 2005 and February 2014, 6 patients with Z-E underwent surgery, 4 men and 
      2 women with a median age 46.8 years (22-61). Two patients were affected with 
      multiple endocrine neoplasia type-1 (MEN-1). Fasting gastrin levels greater than 
      200pg/ml (NV: <100) was diagnostic. Radiologic imaging to localize the lesion 
      included octreoscan 6/6, computer tomography (CT) 6/6, and endoscopic 
      ultrasonography (EUS) 1/6. RESULTS: The octreoscan was positive in 5 patients. 
      The CT localized the tumor in the pancreas in 2 patients, in the duodenum in 3 
      patients (1 confirmed by EUS) and between the common bile duct and vena cava in 
      one patient. The laparoscopic approach was used in 4 patients, 2 patients 
      converted to open surgery. The following surgical techniques were performed: 2 
      pylorus-preserving pancreatico-duodenectomy (PPPD), one spleen-preserving distal 
      pancreatectomy, one duodenal nodular resection, 1 segmental duodenectomy and one 
      extrapancreatic nodular resection. Pathological studies showed lymph nodes 
      metastasis in 2 patients with pancreatic gastrinomas, and in one patient with 
      duodenal gastrinoma. The median follow-up was 76,83 months (5-108) and all 
      patients presented normal fasting gastrin levels. CONCLUSIONS: Surgery may offer 
      a cure in patients with Z-E. The laparoscopic approach remains limited to 
      selected cases.
CI  - Copyright (c) 2014 AEC. Publicado por Elsevier Espana, S.L.U. All rights reserved.
FAU - Fernandez-Cruz, Laureano
AU  - Fernandez-Cruz L
AD  - Departamento de Cirugia, Universidad de Barcelona, Hospital Clinic de Barcelona, 
      Barcelona, Espana. Electronic address: laurefcruz@gmail.com.
FAU - Pelegrina, Amalia
AU  - Pelegrina A
AD  - Departamento de Cirugia, Universidad de Barcelona, Hospital Clinic de Barcelona, 
      Barcelona, Espana.
LA  - spa
PT  - Journal Article
TT  - Cirugia del gastrinoma: Resultados inmediatos y a largo plazo.
DEP - 20150303
PL  - Spain
TA  - Cir Esp
JT  - Cirugia espanola
JID - 1254104
SB  - IM
MH  - Adult
MH  - Female
MH  - Gastrinoma/*surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pancreatic Neoplasms/*surgery
MH  - Time Factors
MH  - Treatment Outcome
MH  - Young Adult
MH  - Zollinger-Ellison Syndrome/*surgery
OTO - NOTNLM
OT  - Familiar gastrinoma
OT  - Gastrinoma esporadico
OT  - Gastrinoma familiar
OT  - Gastrinoma linfatico primario
OT  - Laparoscopia
OT  - Laparoscopy
OT  - Lymph node gastrinoma
OT  - Sporadic gastrinoma
EDAT- 2015/03/10 06:00
MHDA- 2017/06/02 06:00
CRDT- 2015/03/10 06:00
PHST- 2014/07/14 00:00 [received]
PHST- 2014/10/19 00:00 [revised]
PHST- 2014/10/26 00:00 [accepted]
PHST- 2015/03/10 06:00 [entrez]
PHST- 2015/03/10 06:00 [pubmed]
PHST- 2017/06/02 06:00 [medline]
AID - S0009-739X(14)00345-5 [pii]
AID - 10.1016/j.ciresp.2014.10.016 [doi]
PST - ppublish
SO  - Cir Esp. 2015 Jun-Jul;93(6):390-5. doi: 10.1016/j.ciresp.2014.10.016. Epub 2015 
      Mar 3.