PMID- 25748133
OWN - NLM
STAT- MEDLINE
DCOM- 20151019
LR  - 20161125
IS  - 1349-7413 (Electronic)
IS  - 0911-4300 (Linking)
VI  - 37
IP  - 6
DP  - 2014
TI  - Five-year administration of tocilizumab to a patient with rheumatoid arthritis 
      complicated by severe chronic heart failure.
PG  - 488-92
LID - 10.2177/jsci.37.488 [doi]
AB  - We herein described the long-term administration of tocilizumab (TCZ) to a 
      patient with rheumatoid arthritis (RA) complicated by three vessel coronary 
      artery disease and severe heart failure (HF). A 41-year-old male was admitted to 
      our hospital with exacerbated RA and congestive HF. Cardiac ultrasonography 
      revealed diffuse hypokinesis with a left ventricular ejection fraction (LVEF) of 
      16.8% and New York Heart Association (NYHA) class III/IV HF. Swelling and 
      tenderness were noted in most of his joints. Methotrexate (MTX) was initiated 
      during his hospitalization and TCZ was introduced 6 months later. Our patient has 
      been treated with MTX and TCZ for five years without any adverse events, and RA 
      and HF have remained stable. Although it may be anecdotal, we suggest that TCZ 
      may be used as a treatment option in patients with RA complicated by severe HF.
FAU - Suzuki, Akitake
AU  - Suzuki A
AD  - Center for Rheumatology and Joint Surgery, Kawakita General Hospital, Tokyo, 
      Japan.
FAU - Tamamura, Toshitake
AU  - Tamamura T
FAU - Okai, Takahiro
AU  - Okai T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Nihon Rinsho Meneki Gakkai Kaishi
JT  - Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology
JID - 9505992
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - I031V2H011 (tocilizumab)
RN  - YL5FZ2Y5U1 (Methotrexate)
SB  - IM
MH  - Adult
MH  - Antibodies, Monoclonal, Humanized/*administration & dosage
MH  - Arthritis, Rheumatoid/*complications/*drug therapy
MH  - Chronic Disease
MH  - Diagnostic Imaging
MH  - Drug Therapy, Combination
MH  - Heart Failure/diagnosis/*etiology
MH  - Humans
MH  - Male
MH  - Methotrexate/administration & dosage
MH  - Middle Aged
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2014/01/01 00:00
MHDA- 2015/10/20 06:00
CRDT- 2015/03/10 06:00
PHST- 2015/03/10 06:00 [entrez]
PHST- 2014/01/01 00:00 [pubmed]
PHST- 2015/10/20 06:00 [medline]
AID - 10.2177/jsci.37.488 [doi]
PST - ppublish
SO  - Nihon Rinsho Meneki Gakkai Kaishi. 2014;37(6):488-92. doi: 10.2177/jsci.37.488.