PMID- 25748831
OWN - NLM
STAT- MEDLINE
DCOM- 20150526
LR  - 20181211
IS  - 1873-2968 (Electronic)
IS  - 0006-2952 (Linking)
VI  - 94
IP  - 4
DP  - 2015 Apr 15
TI  - Chronic oleoylethanolamide treatment improves spatial cognitive deficits through 
      enhancing hippocampal neurogenesis after transient focal cerebral ischemia.
PG  - 270-81
LID - S0006-2952(15)00131-8 [pii]
LID - 10.1016/j.bcp.2015.02.012 [doi]
AB  - Oleoylethanolamide (OEA) has been shown to have neuroprotective effects after 
      acute cerebral ischemic injury. The aim of this study was to investigate the 
      effects of chronic OEA treatment on ischemia-induced spatial cognitive 
      impairments, electrophysiology behavior and hippocampal neurogenesis. Daily 
      treatments of 30 mg/kg OEA significantly ameliorated spatial cognitive deficits 
      and attenuated the inhibition of long-term potentiation (LTP) in the middle 
      cerebral artery occlusion (MCAO) rat model. Moreover, OEA administration improved 
      cognitive function in a manner associated with enhanced neurogenesis in the 
      hippocampus. Further study demonstrated that treatment with OEA markedly 
      increased the expressions of brain-derived neurotrophic factor (BDNF) and 
      peroxisome proliferator-activated receptors alpha (PPARalpha). Our data suggest that 
      chronic OEA treatment can exert functional recovery of cognitive impairments and 
      neuroprotective effects against cerebral ischemic insult in rats via triggering 
      of neurogenesis in the hippocampus, which supports the therapeutic use of OEA for 
      cerebral ischemia.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Yang, Li-Chao
AU  - Yang LC
AD  - Xiamen Key Laboratory of Chiral Drugs, Medical College, Xiamen University, 
      Xiang'an District, Xiamen 361102, China.
FAU - Guo, Han
AU  - Guo H
AD  - Xiamen Key Laboratory of Chiral Drugs, Medical College, Xiamen University, 
      Xiang'an District, Xiamen 361102, China.
FAU - Zhou, Hao
AU  - Zhou H
AD  - Xiamen Key Laboratory of Chiral Drugs, Medical College, Xiamen University, 
      Xiang'an District, Xiamen 361102, China.
FAU - Suo, Da-Qin
AU  - Suo DQ
AD  - Xiamen Key Laboratory of Chiral Drugs, Medical College, Xiamen University, 
      Xiang'an District, Xiamen 361102, China.
FAU - Li, Wen-Jun
AU  - Li WJ
AD  - Xiamen Key Laboratory of Chiral Drugs, Medical College, Xiamen University, 
      Xiang'an District, Xiamen 361102, China.
FAU - Zhou, Yu
AU  - Zhou Y
AD  - Xiamen Key Laboratory of Chiral Drugs, Medical College, Xiamen University, 
      Xiang'an District, Xiamen 361102, China.
FAU - Zhao, Yun
AU  - Zhao Y
AD  - Xiamen Key Laboratory of Chiral Drugs, Medical College, Xiamen University, 
      Xiang'an District, Xiamen 361102, China.
FAU - Yang, Wu-Shuang
AU  - Yang WS
AD  - Department of Neurosurgery, Xiamen Traditional Chinese Medicine Hospital, Xiamen 
      361005, China.
FAU - Jin, Xin
AU  - Jin X
AD  - Xiamen Key Laboratory of Chiral Drugs, Medical College, Xiamen University, 
      Xiang'an District, Xiamen 361102, China. Electronic address: xinjin@xmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150303
PL  - England
TA  - Biochem Pharmacol
JT  - Biochemical pharmacology
JID - 0101032
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Endocannabinoids)
RN  - 0 (Oleic Acids)
RN  - 0 (PPAR alpha)
RN  - 1HI5J9N8E6 (oleoylethanolamide)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cognition Disorders/drug therapy/*psychology
MH  - Dentate Gyrus/drug effects/physiopathology
MH  - Endocannabinoids
MH  - Hippocampus/*drug effects/pathology/physiopathology
MH  - Ischemic Attack, Transient/*drug therapy/pathology/physiopathology/psychology
MH  - Long-Term Potentiation/drug effects
MH  - Male
MH  - Maze Learning/drug effects
MH  - *Neurogenesis
MH  - Neuroglia/drug effects/pathology
MH  - Neurons/drug effects/pathology
MH  - Oleic Acids/*pharmacology/therapeutic use
MH  - PPAR alpha/metabolism
MH  - Rats, Sprague-Dawley
MH  - Spatial Learning/*drug effects
OTO - NOTNLM
OT  - 3-Aminobenzamide (PubChem CID: 1645)
OT  - 3'-Azido-deoxythymidine (PubChem CID: 451515)
OT  - 5-Bromo-2'-deoxyuridine (PubChem CID: 6035)
OT  - Focal cerebral ischemia
OT  - Hippocampal neurogenesis
OT  - Oleoylethanolamide
OT  - Oleoylethanolamide (PubChem CID: 5283454)
OT  - Rats
OT  - Spatial cognitive function
EDAT- 2015/03/10 06:00
MHDA- 2015/05/27 06:00
CRDT- 2015/03/10 06:00
PHST- 2014/11/25 00:00 [received]
PHST- 2015/02/24 00:00 [accepted]
PHST- 2015/03/10 06:00 [entrez]
PHST- 2015/03/10 06:00 [pubmed]
PHST- 2015/05/27 06:00 [medline]
AID - S0006-2952(15)00131-8 [pii]
AID - 10.1016/j.bcp.2015.02.012 [doi]
PST - ppublish
SO  - Biochem Pharmacol. 2015 Apr 15;94(4):270-81. doi: 10.1016/j.bcp.2015.02.012. Epub 
      2015 Mar 3.