PMID- 25749202
OWN - NLM
STAT- MEDLINE
DCOM- 20151001
LR  - 20191008
IS  - 1879-3304 (Electronic)
IS  - 0039-6257 (Print)
IS  - 0039-6257 (Linking)
VI  - 60
IP  - 3
DP  - 2015 May-Jun
TI  - Role of dendritic cell subsets in immunity and their contribution to 
      noninfectious uveitis.
PG  - 242-9
LID - S0039-6257(15)00004-1 [pii]
LID - 10.1016/j.survophthal.2015.01.003 [doi]
AB  - Dendritic cells (DCs) are a heterogeneous population. Murine DCs consist of 
      conventional DCs (cDCs) and plasmacytoid DCs (pDCs). In humans, the analogous 
      populations are myeloid DCs (mDCs) and pDCs. Though distinct in phenotypes and 
      functions, studies have shown that these DC subsets may interact or "crosstalk" 
      during immune responses. For example, cDCs may facilitate pDC maturation, and 
      pDCs may enhance antigen presentation of cDCs in certain pathogenic conditions or 
      even take on a cDC phenotype themselves. The role of DCs in noninfectious uveitis 
      has been studied primarily in the experimental autoimmune uveitis mouse model and 
      to a more limited extent in patients. Recent evidence shows that the number, 
      phenotype, and function of DC subsets are altered in this disease. We provide an 
      overview of selected recent developments of pDCs and cDCs/mDCs, with special 
      attention to their interaction and the dual roles of DC subsets in noninfectious 
      uveitis.
CI  - Published by Elsevier Inc.
FAU - Chen, Ping
AU  - Chen P
AD  - Laboratory of Immunology, National Eye Institute, National Institutes of Health, 
      Bethesda, Maryland, USA.
FAU - Denniston, Alastair K
AU  - Denniston AK
AD  - Department of Ophthalmology, Queen Elizabeth Hospital Birmingham, University 
      Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
FAU - Hirani, Sima
AU  - Hirani S
AD  - Laboratory of Immunology, National Eye Institute, National Institutes of Health, 
      Bethesda, Maryland, USA.
FAU - Hannes, Susan
AU  - Hannes S
AD  - Laboratory of Immunology, National Eye Institute, National Institutes of Health, 
      Bethesda, Maryland, USA.
FAU - Nussenblatt, Robert B
AU  - Nussenblatt RB
AD  - Laboratory of Immunology, National Eye Institute, National Institutes of Health, 
      Bethesda, Maryland, USA. Electronic address: nussenblattr@nei.nih.gov.
LA  - eng
GR  - Z01 EY000278-08/Intramural NIH HHS/United States
GR  - Z99 EY999999/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Review
DEP - 20150128
PL  - United States
TA  - Surv Ophthalmol
JT  - Survey of ophthalmology
JID - 0404551
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*physiology
MH  - Humans
MH  - Immunity/*physiology
MH  - Signal Transduction/physiology
MH  - Uveitis/*immunology
PMC - PMC4404222
MID - NIHMS669807
OTO - NOTNLM
OT  - conventional dendritic cells
OT  - experimental autoimmune uveitis
OT  - myeloid dendritic cells
OT  - noninfectious uveitis
OT  - plasmacytoid dendritic cells
EDAT- 2015/03/10 06:00
MHDA- 2015/10/02 06:00
PMCR- 2016/05/01
CRDT- 2015/03/10 06:00
PHST- 2014/04/10 00:00 [received]
PHST- 2015/01/20 00:00 [revised]
PHST- 2015/01/20 00:00 [accepted]
PHST- 2015/03/10 06:00 [entrez]
PHST- 2015/03/10 06:00 [pubmed]
PHST- 2015/10/02 06:00 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - S0039-6257(15)00004-1 [pii]
AID - 10.1016/j.survophthal.2015.01.003 [doi]
PST - ppublish
SO  - Surv Ophthalmol. 2015 May-Jun;60(3):242-9. doi: 
      10.1016/j.survophthal.2015.01.003. Epub 2015 Jan 28.