PMID- 25749346
OWN - NLM
STAT- MEDLINE
DCOM- 20160119
LR  - 20150429
IS  - 1479-9731 (Electronic)
IS  - 1479-9723 (Linking)
VI  - 12
IP  - 2
DP  - 2015 May
TI  - Minimal important difference of the 6-minute walk distance in lung cancer.
PG  - 146-54
LID - 10.1177/1479972315575715 [doi]
AB  - The 6-minute walk distance (6MWD) is one of the most commonly used measures of 
      functional capacity in lung cancer, however, the minimal important difference 
      (MID) has not been established. The aims of this exploratory study are, in lung 
      cancer, to estimate (1) the MID of the 6MWD and (2) relationship between 6MWD, 
      demographic and disease-related factors. Fifty-six participants with stage I-IV 
      lung cancer completed the 6MWD prior to treatment and 10 weeks later. No exercise 
      intervention occurred. Additional measures included European Organization for 
      Research and Treatment of Cancer questionnaire (EORTC-QLQ-C30) and questionnaires 
      assessing function, physical activity and symptoms. MID was calculated using 
      anchor- and distribution-based methods. The mean 6MWD decline in participants 
      classed as deteriorated was 60 m compared with 16 m in participants classed as 
      not-deteriorated (p = 0.01). The receiver operating curve indicated a cut-off 
      value for clinically relevant change to be 42 m (95% confidence interval (CI) 
      6-75) (area under curve = 0.66, 95% CI 0.51-0.81) or a 9.5% change. 
      Distribution-based methods indicated an MID between 22 m (95% CI 18-26) and 32 m 
      (95% CI 20-42). Higher 6MWD correlated with better function (r = -0.42, p = 
      0.001), physical activity (r = 0.56, p < 0.005) and dyspnoea (r = -0.44, p = 
      0.001). The MID for deterioration of the 6MWD in lung cancer is estimated to be 
      between 22 m and 42 m or a change of 9.5%.
CI  - (c) The Author(s) 2015.
FAU - Granger, Catherine L
AU  - Granger CL
AD  - Department of Physiotherapy, The University of Melbourne, Parkville, Victoria, 
      Australia Department of Physiotherapy, Royal Melbourne Hospital, Parkville, 
      Victoria, Australia Institute for Breathing and Sleep, Austin Hospital, 
      Heidelberg, Victoria, Australia catherine.granger@unimelb.edu.au.
FAU - Holland, Anne E
AU  - Holland AE
AD  - Institute for Breathing and Sleep, Austin Hospital, Heidelberg, Victoria, 
      Australia Department of Physiotherapy, La Trobe University, Melbourne, Victoria, 
      Australia Department of Physiotherapy, Alfred Hospital, Prahran, Victoria, 
      Australia.
FAU - Gordon, Ian R
AU  - Gordon IR
AD  - Statistical Consulting Centre, The University of Melbourne, Parkville, Victoria, 
      Australia.
FAU - Denehy, Linda
AU  - Denehy L
AD  - Department of Physiotherapy, The University of Melbourne, Parkville, Victoria, 
      Australia Institute for Breathing and Sleep, Austin Hospital, Heidelberg, 
      Victoria, Australia.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20150306
PL  - England
TA  - Chron Respir Dis
JT  - Chronic respiratory disease
JID - 101197408
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Non-Small-Cell Lung/*physiopathology/therapy
MH  - Exercise Test/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Lung Neoplasms/*physiopathology/therapy
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - ROC Curve
MH  - *Walking
OTO - NOTNLM
OT  - 6-minute walk distance (6MWD)
OT  - Lung cancer
OT  - MID
OT  - functional capacity
OT  - minimal important difference
EDAT- 2015/03/10 06:00
MHDA- 2016/01/20 06:00
CRDT- 2015/03/10 06:00
PHST- 2015/03/10 06:00 [entrez]
PHST- 2015/03/10 06:00 [pubmed]
PHST- 2016/01/20 06:00 [medline]
AID - 1479972315575715 [pii]
AID - 10.1177/1479972315575715 [doi]
PST - ppublish
SO  - Chron Respir Dis. 2015 May;12(2):146-54. doi: 10.1177/1479972315575715. Epub 2015 
      Mar 6.