PMID- 25749780
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150404
LR  - 20201001
IS  - 2092-7355 (Print)
IS  - 2092-7363 (Electronic)
IS  - 2092-7355 (Linking)
VI  - 7
IP  - 3
DP  - 2015 May
TI  - Association of Single Nucleotide Polymorphisms in the MD-2 Gene Promoter Region 
      With Der p 2 Allergy.
PG  - 249-55
LID - 10.4168/aair.2015.7.3.249 [doi]
AB  - PURPOSE: Sensitization to house dust mite (Dermatophagoides pteronyssinus) is a 
      considerable risk factor for the progression of allergic disease. The group 2 
      allergen from Dermatophagoides pteronyssinus, Der p 2, is considered a major one 
      in patients with specific immunoglobulin E (IgE) to Der p 2. Der p 2 has 
      structural homology with myeloid differentiation 2 (MD-2), which is involved in 
      the lipopolysaccharide-binding component of the Toll-like receptor 4 signaling 
      pathway and the development of inflammation. The aim of this study was to examine 
      the genetic association of single nucleotide polymorphisms (SNPs) in the promoter 
      region of MD-2 with Der p 2-sensitive allergy. METHODS: We investigated 
      associations between cohort's characteristics, including 280 allergic and 80 
      healthy subjects by examining total IgE, eosinophils, D. pteronyssinus-specific 
      IgE, Der p 2-specific IgE, the number of IgE-producing B cells induced by Der p 
      2, and the odds ratio of allergic symptoms. RESULTS: Based on the 1,000 genome 
      project data, the minor allele frequencies of the rs1809441 and rs1809442 are 
      0.467 and 0.474, respectively. However, the correlation of linkage disequilibrium 
      (LD) between these 2 SNPs is D'=1, the genotype frequencies of the 2 MD-2 (LY96) 
      SNPs (rs1809441 and rs1809442) that are located nearby were significantly 
      different between allergic and health subjects: the TT genotype of rs1809441 and 
      the GG genotype of rs1809442 were more frequent in allergic subjects than in 
      healthy subjects (16.1% vs 2.5% in both genotypes). The allergic patients with 
      these genotypes exhibited significantly higher levels of D. 
      pteronyssinus-specific IgE and Der p 2-specific Ig E, and a larger number of Der 
      p 2-activated B cells. In addition, these 2 SNPs in the MD-2 promoter region were 
      significantly associated with the prevalence of nasal, skin, and asthmatic 
      allergic symptoms. CONCLUSIONS: Our results indicated that 2 SNPs in the MD-2 
      promoter region were significantly associated with Der p 2-specific Ig E, and 
      thereby suggest that these SNPs may play a major role in susceptibility to Der p 
      2-triggered immune responses in a Taiwanese population.
FAU - Liao, En Chih
AU  - Liao EC
AD  - Center for Translational Medicine, Department of Medical Research, Taichung 
      Veterans General Hospital, Taichung, Taiwan.; Department of BioIndustry 
      Technology, Da Yeh University, Changhua, Taiwan.; Department of Medical 
      Technology, Jen-Ten College of Medicine, Nursing and Management, Miaoli, Taiwan.
FAU - Chang, Ching Yun
AU  - Chang CY
AD  - Division of Allergy, Immunology & Rheumatology, Department of Internal Medicine, 
      Taichung Veterans General Hospital, Taichung, Taiwan.
FAU - Wu, Chia Che
AU  - Wu CC
AD  - Department of Mechanical Engineering, National Chung-Hsing University, Taichung, 
      Taiwan.
FAU - Wang, Gou Jen
AU  - Wang GJ
AD  - Graduate Institute of Biomedical Engineering, National Chung-Hsing University, 
      Taichung, Taiwan.
FAU - Tsai, Jaw Ji
AU  - Tsai JJ
AD  - Division of Allergy, Immunology & Rheumatology, Department of Internal Medicine, 
      Taichung Veterans General Hospital, Taichung, Taiwan.; College of Life Sciences, 
      National Chung-Hsing University, Taichung, Taiwan.; Institute of Clinical 
      Medicine, National Yang Ming University, Taipei, Taiwan. jawji@vghtc.gov.tw.
LA  - eng
PT  - Journal Article
DEP - 20150305
PL  - Korea (South)
TA  - Allergy Asthma Immunol Res
JT  - Allergy, asthma & immunology research
JID - 101518382
PMC - PMC4397365
OTO - NOTNLM
OT  - Der p 2
OT  - Dermatophagoides pteronyssinus
OT  - mite allergy
OT  - myeloid differentiation-2 (MD-2)
OT  - single nucleotide polymorphisms (SNPs)
COIS- There are no financial or other issues that might lead to conflict of interest.
EDAT- 2015/03/10 06:00
MHDA- 2015/03/10 06:01
PMCR- 2015/05/01
CRDT- 2015/03/10 06:00
PHST- 2014/09/01 00:00 [received]
PHST- 2014/10/31 00:00 [revised]
PHST- 2014/11/10 00:00 [accepted]
PHST- 2015/03/10 06:00 [entrez]
PHST- 2015/03/10 06:00 [pubmed]
PHST- 2015/03/10 06:01 [medline]
PHST- 2015/05/01 00:00 [pmc-release]
AID - 7.e24 [pii]
AID - 10.4168/aair.2015.7.3.249 [doi]
PST - ppublish
SO  - Allergy Asthma Immunol Res. 2015 May;7(3):249-55. doi: 10.4168/aair.2015.7.3.249. 
      Epub 2015 Mar 5.