PMID- 25750063
OWN - NLM
STAT- MEDLINE
DCOM- 20160211
LR  - 20221207
IS  - 1574-4647 (Electronic)
IS  - 0161-9152 (Print)
IS  - 0161-9152 (Linking)
VI  - 37
IP  - 2
DP  - 2015
TI  - Mediterranean diet and leukocyte telomere length in a multi-ethnic elderly 
      population.
PG  - 24
LID - 10.1007/s11357-015-9758-0 [doi]
LID - 24
AB  - Leukocyte telomere length (LTL) is considered as the marker of biological aging 
      and may be related to environmental factors. The current study aimed to examine 
      the relation between Mediterranean-type diet and LTL. We used a cross-sectional 
      study of 1743 multi-ethnic community residents of New York aged 65 years or 
      older. Mediterranean-type diet (MeDi) was calculated from dietary information 
      collected using a food frequency questionnaire. LTL was measured from leukocyte 
      DNA using a real-time PCR method to measure T/S ratio, the ratio of telomere (T) 
      to single-copy gene (S) sequence. Regression analysis showed that the MeDi score 
      was not associated with LTL in the overall study population (beta = 12.5; p = 0.32) 
      after adjusting for age, sex, education, ethnicity, caloric intake, smoking, and 
      physical and leisure activities. However, we found a significant association 
      between MeDi and LTL among non-Hispanic whites (beta = 48.3; p = 0.05), and the 
      results held after excluding dementia subjects (beta = 49.6; p = 0.05). We further 
      found that, in the whole population, vegetable and cereal consumption above the 
      sex-specific population median was associated with longer LTL (beta = 89.1, 
      p = 0.04) and shorter LTL (beta = -93.5; p = 0.03), respectively. Among non-Hispanic 
      whites, intake of meat or dairy below sex-specific population medians was 
      associated with longer LTL (beta = 154.7, p = 0.05; beta = 240.5, p < 0.001, 
      respectively). We found that higher adherence to a MeDi was associated with 
      longer LTL among whites but not among African Americans and Hispanics. 
      Additionally, a diet high in vegetables but low in cereal, meat, and dairy might 
      be associated with longer LTL among healthy elderly.
FAU - Gu, Yian
AU  - Gu Y
AD  - The Taub Institute for Research in Alzheimer's Disease and the Aging Brain, 
      Columbia University Medical Center, 622 W 168th St., P&S #16, New York, NY, 
      10032, USA.
FAU - Honig, Lawrence S
AU  - Honig LS
FAU - Schupf, Nicole
AU  - Schupf N
FAU - Lee, Joseph H
AU  - Lee JH
FAU - Luchsinger, Jose A
AU  - Luchsinger JA
FAU - Stern, Yaakov
AU  - Stern Y
FAU - Scarmeas, Nikolaos
AU  - Scarmeas N
LA  - eng
GR  - K99AG042483/AG/NIA NIH HHS/United States
GR  - K99 AG042483/AG/NIA NIH HHS/United States
GR  - P01AG07232/AG/NIA NIH HHS/United States
GR  - P60 MD000206/MD/NIMHD NIH HHS/United States
GR  - P60MD000206/MD/NIMHD NIH HHS/United States
GR  - P01 AG007232/AG/NIA NIH HHS/United States
GR  - R01AG028506/AG/NIA NIH HHS/United States
GR  - R01AG037212/AG/NIA NIH HHS/United States
GR  - R01 AG037212/AG/NIA NIH HHS/United States
GR  - R01 AG028506/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150308
PL  - Netherlands
TA  - Age (Dordr)
JT  - Age (Dordrecht, Netherlands)
JID - 101250497
SB  - IM
MH  - Black or African American
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - *Diet, Mediterranean
MH  - Ethnicity
MH  - Female
MH  - Health Behavior
MH  - Hispanic or Latino
MH  - Humans
MH  - Life Style
MH  - Male
MH  - Patient Compliance
MH  - Telomere Homeostasis/*physiology
MH  - White People
PMC - PMC4352412
EDAT- 2015/03/10 06:00
MHDA- 2016/02/13 06:00
PMCR- 2016/04/01
CRDT- 2015/03/10 06:00
PHST- 2014/09/30 00:00 [received]
PHST- 2015/02/13 00:00 [accepted]
PHST- 2015/03/10 06:00 [entrez]
PHST- 2015/03/10 06:00 [pubmed]
PHST- 2016/02/13 06:00 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - 9758 [pii]
AID - 10.1007/s11357-015-9758-0 [doi]
PST - ppublish
SO  - Age (Dordr). 2015;37(2):24. doi: 10.1007/s11357-015-9758-0. Epub 2015 Mar 8.