PMID- 25750531
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150309
LR  - 20201001
IS  - 1176-6328 (Print)
IS  - 1178-2021 (Electronic)
IS  - 1176-6328 (Linking)
VI  - 11
DP  - 2015
TI  - Minocycline upregulates cyclic AMP response element binding protein and 
      brain-derived neurotrophic factor in the hippocampus of cerebral ischemia rats 
      and improves behavioral deficits.
PG  - 507-16
LID - 10.2147/NDT.S73836 [doi]
AB  - BACKGROUND AND PURPOSE: The cAMP response element binding protein (CREB) plays an 
      important role in the mechanism of cognitive impairment and is also pivotal in 
      the switch from short-term to long-term memory. Brain-derived neurotrophic factor 
      (BDNF) seems a promising avenue in the treatment of cerebral ischemia injury 
      since this neurotrophin could stimulate structural plasticity and repair 
      cognitive impairment. Several findings have displayed that the dysregulation of 
      the CREB-BDNF cascade has been involved in cognitive impairment. The aim of this 
      study was to investigate the effect of cerebral ischemia on learning and memory 
      as well as on the levels of CREB, phosphorylated CREB (pCREB), and BDNF, and to 
      determine the effect of minocycline on CREB, pCREB, BDNF, and behavioral 
      functional recovery after cerebral ischemia. METHODS: The animal model was 
      established by permanent bilateral occlusion of both common carotid arteries. 
      Behavior was evaluated 5 days before decapitation with Morris water maze and 
      open-field task. Four days after permanent bilateral occlusion of both common 
      carotid arteries, minocycline was administered by douche via the stomach for 4 
      weeks. CREB and pCREB were examined by Western blotting, reverse transcription 
      polymerase chain reaction, and immunohistochemistry. BDNF was measured by 
      immunohistochemistry and Western blotting. RESULTS: The model rats after 
      minocycline treatment swam shorter distances than control rats before finding the 
      platform (P=0.0007). The number of times the platform position was crossed for 
      sham-operation rats was more than that of the model groups in the corresponding 
      platform location (P=0.0021). The number of times the platform position was 
      crossed for minocycline treatment animals was significantly increased compared to 
      the model groups in the corresponding platform position (P=0.0016). CREB, pCREB, 
      and BDNF were downregulated after permanent bilateral occlusion of both common 
      carotid arteries in the model group. Minocycline increased the expression of 
      CREB, pCREB, and BDNF, and improved cognitive suffered from impairment of 
      permanent bilateral occlusion of both common carotid arteries. CONCLUSION: 
      Minocycline improved cognitive impairment from cerebral ischemia via enhancing 
      CREB, pCREB, and BDNF activity in the hippocampus.
FAU - Zhao, Yu
AU  - Zhao Y
AD  - Department of Neurology, the Fourth Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang Province, People's Republic of China.
FAU - Xiao, Ming
AU  - Xiao M
AD  - Department of Anatomy, Nanjing Medical University, Nanjing, Jiangsu, People's 
      Republic of China.
FAU - He, Wenbo
AU  - He W
AD  - Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan 
      Renmin Hospital, Shiyan, Hubei Province, People's Republic of China.
FAU - Cai, Zhiyou
AU  - Cai Z
AD  - Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan 
      Renmin Hospital, Shiyan, Hubei Province, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20150226
PL  - New Zealand
TA  - Neuropsychiatr Dis Treat
JT  - Neuropsychiatric disease and treatment
JID - 101240304
PMC - PMC4348135
OTO - NOTNLM
OT  - cAMP response element binding protein
OT  - cerebral ischamia
OT  - neuroprotection
OT  - vascular cognitive impairment
EDAT- 2015/03/10 06:00
MHDA- 2015/03/10 06:01
PMCR- 2015/02/26
CRDT- 2015/03/10 06:00
PHST- 2015/03/10 06:00 [entrez]
PHST- 2015/03/10 06:00 [pubmed]
PHST- 2015/03/10 06:01 [medline]
PHST- 2015/02/26 00:00 [pmc-release]
AID - ndt-11-507 [pii]
AID - 10.2147/NDT.S73836 [doi]
PST - epublish
SO  - Neuropsychiatr Dis Treat. 2015 Feb 26;11:507-16. doi: 10.2147/NDT.S73836. 
      eCollection 2015.