PMID- 25750588
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150309
LR  - 20220330
IS  - 1477-9560 (Print)
IS  - 1477-9560 (Electronic)
IS  - 1477-9560 (Linking)
VI  - 12
DP  - 2014
TI  - Measurement of non-VKA oral anticoagulants versus classic ones: the appropriate 
      use of hemostasis assays.
PG  - 24
LID - 10.1186/1477-9560-12-24 [doi]
LID - 24
AB  - Traditional anticoagulant agents such as vitamin K antagonists (VKAs), 
      unfractionated heparin (UFH), low molecular weight heparins (LMWHs) and 
      fondaparinux have been widely used in the prevention and treatment of 
      thromboembolic diseases. However, these agents are associated with limitations, 
      such as the need for regular coagulation monitoring (VKAs and UFH) or a 
      parenteral route of administration (UFH, LMWHs and fondaparinux). Several non-VKA 
      oral anticoagulants (NOACs) are now widely used in the prevention and treatment 
      of thromboembolic diseases and in stroke prevention in non-valvular atrial 
      fibrillation. Unlike VKAs, NOACs exhibit predictable pharmacokinetics and 
      pharmacodynamics. They are therefore usually given at fixed doses without routine 
      coagulation monitoring. However, in certain patient populations or special 
      clinical circumstances, measurement of drug exposure may be useful, such as in 
      suspected overdose, in patients experiencing a hemorrhagic or thromboembolic 
      event during the treatment's period, in those with acute renal failure, in 
      patients who require urgent surgery or in case of an invasive procedure. This 
      article aims at providing guidance on laboratory testing of classic 
      anticoagulants and NOACs.
FAU - Douxfils, Jonathan
AU  - Douxfils J
AD  - Department of Pharmacy, Namur Thrombosis and Hemostasis Center (NTHC), Namur 
      Research Institute for LIfe Sciences (NARILIS), University of Namur, Namur, 
      Belgium.
FAU - Tamigniau, Anne
AU  - Tamigniau A
AD  - Hematology Laboratory, Namur Thrombosis and Hemostasis Center (NTHC), Namur 
      Research Institute for LIfe Sciences (NARILIS), CHU Dinant Godinne UcL Namur, 
      Universite Catholique de Louvain, 1, avenue Dr Gaston Therasse, B5530 Yvoir, 
      Belgium.
FAU - Chatelain, Bernard
AU  - Chatelain B
AD  - Hematology Laboratory, Namur Thrombosis and Hemostasis Center (NTHC), Namur 
      Research Institute for LIfe Sciences (NARILIS), CHU Dinant Godinne UcL Namur, 
      Universite Catholique de Louvain, 1, avenue Dr Gaston Therasse, B5530 Yvoir, 
      Belgium.
FAU - Goffinet, Catherine
AU  - Goffinet C
AD  - Clinique et Maternite Sainte-Elisabeth, Namur, Belgium.
FAU - Dogne, Jean-Michel
AU  - Dogne JM
AD  - Department of Pharmacy, Namur Thrombosis and Hemostasis Center (NTHC), Namur 
      Research Institute for LIfe Sciences (NARILIS), University of Namur, Namur, 
      Belgium.
FAU - Mullier, Francois
AU  - Mullier F
AD  - Department of Pharmacy, Namur Thrombosis and Hemostasis Center (NTHC), Namur 
      Research Institute for LIfe Sciences (NARILIS), University of Namur, Namur, 
      Belgium ; Hematology Laboratory, Namur Thrombosis and Hemostasis Center (NTHC), 
      Namur Research Institute for LIfe Sciences (NARILIS), CHU Dinant Godinne UcL 
      Namur, Universite Catholique de Louvain, 1, avenue Dr Gaston Therasse, B5530 
      Yvoir, Belgium.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20141104
PL  - England
TA  - Thromb J
JT  - Thrombosis journal
JID - 101170542
PMC - PMC4351835
OTO - NOTNLM
OT  - Apixaban
OT  - Dabigatran
OT  - Enoxaparin
OT  - Low molecular weight heparin
OT  - Monitoring
OT  - Non-VKA oral anticoagulants
OT  - Rivaroxaban
OT  - Vitamin K antagonist
EDAT- 2014/01/01 00:00
MHDA- 2014/01/01 00:01
PMCR- 2014/11/04
CRDT- 2015/03/10 06:00
PHST- 2014/03/11 00:00 [received]
PHST- 2014/10/06 00:00 [accepted]
PHST- 2015/03/10 06:00 [entrez]
PHST- 2014/01/01 00:00 [pubmed]
PHST- 2014/01/01 00:01 [medline]
PHST- 2014/11/04 00:00 [pmc-release]
AID - 215 [pii]
AID - 10.1186/1477-9560-12-24 [doi]
PST - epublish
SO  - Thromb J. 2014 Nov 4;12:24. doi: 10.1186/1477-9560-12-24. eCollection 2014.