PMID- 25750735
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150309
LR  - 20200930
IS  - 2051-7599 (Print)
IS  - 2051-7599 (Electronic)
IS  - 2051-7599 (Linking)
VI  - 7
DP  - 2015
TI  - Solving the puzzle of autoimmunity: critical questions.
PG  - 17
LID - 10.12703/P7-17 [doi]
LID - 17
AB  - Despite recent advances in delineating the pathogenic mechanisms of autoimmune 
      disease, the puzzle that reveals the true picture of these diverse immunological 
      disorders is yet to be solved. We know that the human leukocyte antigen (HLA) 
      loci as well as many different genetic susceptibility loci with relatively small 
      effect sizes predispose to various autoimmune diseases and that environmental 
      factors are involved in triggering disease. Models for mechanisms of disease 
      become increasingly complex as relationships between components of both the 
      adaptive and innate immune systems are untangled at the molecular level. In this 
      article, we pose some of the important questions about autoimmunity where the 
      answers will advance our understanding of disease pathogenesis and improve the 
      rational design of novel therapies. How is autoimmunity triggered, and what 
      components of the immune response drive the clinical manifestations of disease? 
      What determines whether a genetically predisposed individual will develop an 
      autoimmune disease? Is restoring immune tolerance the secret to finding cures for 
      autoimmune disease? Current research efforts seek answers to these big questions.
FAU - Smilek, Dawn E
AU  - Smilek DE
AD  - Immune Tolerance Network 185 Berry Street #3515, San Francisco, CA 94107 USA.
FAU - St Clair, E William
AU  - St Clair EW
AD  - Immune Tolerance Network 185 Berry Street #3515, San Francisco, CA 94107 USA ; 
      Department of Medicine, Division of Rheumatology and Immunology, School of 
      Medicine, Duke University Durham, NC 27710 USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150203
PL  - England
TA  - F1000Prime Rep
JT  - F1000prime reports
JID - 101599397
PMC - PMC4335798
EDAT- 2015/03/10 06:00
MHDA- 2015/03/10 06:01
PMCR- 2015/02/03
CRDT- 2015/03/10 06:00
PHST- 2015/03/10 06:00 [entrez]
PHST- 2015/03/10 06:00 [pubmed]
PHST- 2015/03/10 06:01 [medline]
PHST- 2015/02/03 00:00 [pmc-release]
AID - 17 [pii]
AID - 10.12703/P7-17 [doi]
PST - epublish
SO  - F1000Prime Rep. 2015 Feb 3;7:17. doi: 10.12703/P7-17. eCollection 2015.