PMID- 25751300
OWN - NLM
STAT- MEDLINE
DCOM- 20160418
LR  - 20150722
IS  - 1541-1087 (Electronic)
IS  - 0731-5724 (Linking)
VI  - 34
IP  - 4
DP  - 2015
TI  - Effects of Alpha-Lipoic Acid Supplementation on Inflammatory Biomarkers and 
      Matrix Metalloproteinase-3 in Rheumatoid Arthritis Patients.
PG  - 310-7
LID - 10.1080/07315724.2014.910740 [doi]
AB  - OBJECTIVE: Although many studies have considered alpha-lipoic acid (ALA) as a 
      potent antioxidant with anti-inflammatory functions in oxidative 
      stress-associated inflammatory diseases, few studies have evaluated its efficacy 
      in rheumatoid arthritis (RA). Therefore, we aimed to examine the effects of ALA 
      on serum biomarkers of joint damage and inflammation in women with RA. METHODS: 
      We performed a randomized, double-blind, placebo-controlled clinical trial in 
      which RA patients (n = 70) aged 20-50 years were randomly assigned 1:1 to receive 
      either ALA (1200 mg/day) or placebo for 8 weeks. Fasting blood samples were taken 
      before and after the study to analyze inflammatory biomarkers including serum 
      high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha 
      (TNF-alpha), interleukin-6 (IL-6), and serum matrix metalloproteinase-3 (MMP-3) as a 
      marker of joint erosion. Moreover, 3-day dietary records, the International 
      Physical Activity Questionnaire (IPAQ), and the Spielberger State-Trait anxiety 
      inventory form Y (STAI-Y) were assessed before and after the intervention. 
      RESULTS: Sixty-five RA patients completed the trial. No statistically significant 
      differences were observed in serum levels of hs-CRP, TNF-alpha, IL-6, and MMP-3 
      within and between the ALA and placebo groups (p > 0.05). There were no 
      statistically significant differences in dietary intakes, physical activity, and 
      anxiety levels between groups at baseline and they remained statistically 
      unchanged during the study period (p > 0.05). CONCLUSION: Although in theory ALA 
      supplementation could serve as a beneficial nutraceutical in RA patients, in the 
      present study serum inflammatory biomarkers and MMP-3 were not significantly 
      affected by 8 weeks of ALA supplementation.
FAU - Mirtaheri, Elham
AU  - Mirtaheri E
AD  - a Tabriz University of Medical Science , Tabriz , ISLAMIC REPUBLIC OF IRAN.
FAU - Gargari, Bahram Pourghassem
AU  - Gargari BP
FAU - Kolahi, Sousan
AU  - Kolahi S
FAU - Dehghan, Parvin
AU  - Dehghan P
FAU - Asghari-Jafarabadi, Mohammad
AU  - Asghari-Jafarabadi M
FAU - Hajalilou, Mehrzad
AU  - Hajalilou M
FAU - Shakiba Novin, Zahra
AU  - Shakiba Novin Z
FAU - Mesgari Abbasi, Mehran
AU  - Mesgari Abbasi M
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20150309
PL  - United States
TA  - J Am Coll Nutr
JT  - Journal of the American College of Nutrition
JID - 8215879
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (IL6 protein, human)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 12001-76-2 (Vitamin B Complex)
RN  - 73Y7P0K73Y (Thioctic Acid)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Antioxidants/pharmacology
MH  - Arthritis, Rheumatoid/*blood
MH  - Biomarkers/blood
MH  - C-Reactive Protein/metabolism
MH  - *Dietary Supplements
MH  - Double-Blind Method
MH  - Humans
MH  - Inflammation/*blood
MH  - Inflammation Mediators/*blood
MH  - Interleukin-6/blood
MH  - Joints/drug effects
MH  - Matrix Metalloproteinase 3/*blood
MH  - Middle Aged
MH  - Oxidative Stress
MH  - Thioctic Acid/pharmacology/*therapeutic use
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Vitamin B Complex/pharmacology/therapeutic use
MH  - Young Adult
OTO - NOTNLM
OT  - alpha-lipoic acid
OT  - bioactive compounds
OT  - chronic disease
OT  - clinical trials
OT  - nutriceuticals
OT  - supplement
EDAT- 2015/03/10 06:00
MHDA- 2016/04/19 06:00
CRDT- 2015/03/10 06:00
PHST- 2015/03/10 06:00 [entrez]
PHST- 2015/03/10 06:00 [pubmed]
PHST- 2016/04/19 06:00 [medline]
AID - 10.1080/07315724.2014.910740 [doi]
PST - ppublish
SO  - J Am Coll Nutr. 2015;34(4):310-7. doi: 10.1080/07315724.2014.910740. Epub 2015 
      Mar 9.