PMID- 25751954
OWN - NLM
STAT- MEDLINE
DCOM- 20150508
LR  - 20150310
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 39
IP  - 20
DP  - 2014 Oct
TI  - [Study on effect and mechanism of cinnabaris and realgar in promoting awake of 
      endotoxin-induced brain injury rat applied with Angong Niuhuang Wan].
PG  - 4007-12
AB  - OBJECTIVE: To explore the effect and mechanism of cinnabaris and realgar in 
      promoting awake effect of endotoxin- induced brain injury rat applied with Angong 
      Niuhuang Wan. METHOD: Normal rats implanted cortical electrode in advance were 
      divided into 6 groups: control, model, the Angong Niuhuang Wan (AGNH, 0.4, 0.2 g 
      . kg(-1)), the Angong Niuhuang Wan without cinnabaris and realgar (QZX-AGNH, 
      0.32, 0.16 g . kg(-1)). Rats in the control and model groups were given distilled 
      water. After three days of intragastric administration, the brain injury model 
      was injected with endotoxin through tail vein. Then trace electro-corticogram 
      (EcoG) 1-6 h after LPS injection, and compare the power and relative power of 
      beta (beta) and delta-waves (delta) at 6 h of these groups. The content of acetylcholine 
      (Ach) and the affinity of M-receptor (M-R) in cortex and brainstem were detected 
      by alkaline hydroxylamine colorimetric method and radioactive ligand binding 
      assay, respectively. RESULT: AGNH (0.4, 0.2 g . kg(-1)) could increase the power 
      and relative power of beta and AGNH (0.4 g . kg(-1)) showed better action on brain 
      electrical activation. QZX-AGNH showed weak effect on it. AGNH (0.4 g . kg(-1)) 
      could increase the affinity of M-R in cortex and the content of Ach in brainstem. 
      The action of QZX-AGNH was not obvious. CONCLUSION: In endotoxin-induced brain 
      injury rats, AGNH can raise the cholinergic system function of cortex, and 
      strengthen the uplink of cortex activation of brainstem cholinergic system, 
      improve the level of cortical activity and enhance the activation of EcoG to 
      promote the body's awakening. QZX-AGNH show weak effect. Cinnabaris and realgar 
      play an important role in promoting awake effect in endotoxin-induced brain 
      injury applied with Angong Niuhuang Wan. The mechanism may be related to cortical 
      and brainstem cholinergic system function.
FAU - Zhu, Kun-Jie
AU  - Zhu KJ
FAU - Sun, Jian-Ning
AU  - Sun JN
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Drug Combinations)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Endotoxins)
SB  - IM
MH  - Animals
MH  - Brain Injuries/chemically induced/*drug therapy/physiopathology
MH  - Drug Combinations
MH  - Drugs, Chinese Herbal/*administration & dosage
MH  - Endotoxins/adverse effects
MH  - Humans
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2015/03/11 06:00
MHDA- 2015/05/09 06:00
CRDT- 2015/03/11 06:00
PHST- 2015/03/11 06:00 [entrez]
PHST- 2015/03/11 06:00 [pubmed]
PHST- 2015/05/09 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2014 Oct;39(20):4007-12.