PMID- 25753130
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 8
IP  - 2
DP  - 2016 Mar
TI  - Lipopolysaccharide-binding protein cannot independently predict type 2 diabetes 
      mellitus: A nested case-control study.
PG  - 214-9
LID - 10.1111/1753-0407.12281 [doi]
AB  - BACKGROUND: Cross-sectional studies have reported a close association between 
      serum lipopolysaccharide-binding protein (LBP) and many metabolic disorders. 
      However, no longitudinal study has explored the relationship between LBP and type 
      2 diabetes mellitus (T2DM). The aim of the present study was to investigate the 
      association between serum LBP levels and the risk of developing T2DM. METHODS: A 
      5-year nested case-control study of 3510 individuals was performed as part of the 
      Environment, Inflammation and Metabolic Diseases Study (EIMDS). Clinical data 
      were collected at baseline. Serum levels of LBP and other biochemical factors, 
      such as insulin and high-sensitivity C-reactive protein, were detected 5 years 
      later. Subjects were diagnosed as having T2DM on the basis of results of an oral 
      glucose tolerance test (OGTT) and 1998 World Health Organization criteria. 
      Controls were randomly selected to match cases according to age, gender, and body 
      mass index (BMI) in a 1:1 ratio. Odds ratios (OR) for T2DM were calculated using 
      conditional logistic regression analysis. RESULTS: Over a 5-year follow-up 
      period, 255 subjects developed T2DM. There was no significant difference in serum 
      LBP levels between the T2DM and control groups at baseline (19.78 +/- 6.40 versus 
      20.53 +/- 6.99 mug/mL; P = 0.207). Subjects were divided into three groups based on 
      tertiles of LBP concentrations (n = 170 in each group; T1 = 1.31-17.16 mug/mL LBP; 
      T2 = 17.21-22.37 mug/mL LBP; T3 = 22.49-40.08 mug/mL LBP). There was no significant 
      association between the risk of developing T2DM and any of the LBP tertiles in 
      either a simple model or after adjusting for general status and biochemical 
      factors. CONCLUSION: After matching for gender, age, and BMI, LBP does not 
      improve prediction of the development of T2DM independently.
CI  - (c) 2015 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley 
      Publishing Asia Pty Ltd.
FAU - Zhou, Huang
AU  - Zhou H
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Hu, Jinbo
AU  - Hu J
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Zhu, Qibo
AU  - Zhu Q
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Yang, Shumin
AU  - Yang S
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - Hospital of Chongqing University, Chongqing, China.
FAU - Gao, Rufei
AU  - Gao R
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Liu, Lulu
AU  - Liu L
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Wang, Yue
AU  - Wang Y
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Zhen, Qianna
AU  - Zhen Q
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Lv, Qiong
AU  - Lv Q
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Li, Qifu
AU  - Li Q
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150518
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (Insulin)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (lipopolysaccharide-binding protein)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Acute-Phase Proteins
MH  - Aged
MH  - Body Mass Index
MH  - C-Reactive Protein/metabolism
MH  - Carrier Proteins/*blood
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood/*diagnosis
MH  - Female
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin/blood
MH  - Logistic Models
MH  - Male
MH  - Membrane Glycoproteins/*blood
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Risk Assessment
MH  - Risk Factors
MH  - Time Factors
OTO - NOTNLM
OT  - diabetes
OT  - endotoxinemia
OT  - lipopolysaccharide-binding protein
OT  - risk
OT  - 内毒素血症
OT  - 糖尿病
OT  - 脂多糖结合蛋白
OT  - 风险
EDAT- 2015/03/11 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/03/11 06:00
PHST- 2014/10/27 00:00 [received]
PHST- 2015/01/30 00:00 [revised]
PHST- 2015/02/20 00:00 [accepted]
PHST- 2015/03/11 06:00 [entrez]
PHST- 2015/03/11 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.1111/1753-0407.12281 [doi]
PST - ppublish
SO  - J Diabetes. 2016 Mar;8(2):214-9. doi: 10.1111/1753-0407.12281. Epub 2015 May 18.