PMID- 25753415
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210102
IS  - 2211-1247 (Electronic)
VI  - 10
IP  - 9
DP  - 2015 Mar 10
TI  - IgE/FcepsilonRI-Mediated Antigen Cross-Presentation by Dendritic Cells Enhances 
      Anti-Tumor Immune Responses.
PG  - 1487-1495
LID - S2211-1247(15)00143-6 [pii]
LID - 10.1016/j.celrep.2015.02.015 [doi]
AB  - Epidemiologic studies discovered an inverse association between immunoglobulin E 
      (IgE)-mediated allergies and cancer, implying tumor-protective properties of IgE. 
      However, the underlying immunologic mechanisms remain poorly understood. Antigen 
      cross-presentation by dendritic cells (DCs) is of key importance for anti-tumor 
      immunity because it induces the generation of cytotoxic CD8(+) T lymphocytes 
      (CTLs) with specificity for tumor antigens. We demonstrate that DCs use IgE and 
      FcepsilonRI, the high-affinity IgE receptor, for cross-presentation and priming of CTLs 
      in response to free soluble antigen at low doses. Importantly, IgE/FcepsilonRI-mediated 
      cross-presentation is a distinct receptor-mediated pathway because it does not 
      require MyD88 signals or IL-12 induction in DCs. Using passive immunization with 
      tumor antigen-specific IgE and DC-based vaccination experiments, we demonstrate 
      that IgE-mediated cross-presentation significantly improves anti-tumor immunity 
      and induces memory responses in vivo. Our findings suggest a cellular mechanism 
      for the tumor-protective features of IgE and expand the known physiological 
      functions of this immunoglobulin.
CI  - Copyright (c) 2015 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Platzer, Barbara
AU  - Platzer B
AD  - Division of Gastroenterology and Nutrition, Boston Children's Hospital and 
      Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
FAU - Elpek, Kutlu G
AU  - Elpek KG
AD  - Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, 
      MA 02115, USA.
FAU - Cremasco, Viviana
AU  - Cremasco V
AD  - Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, 
      MA 02115, USA.
FAU - Baker, Kristi
AU  - Baker K
AD  - Division of Gastroenterology, Brigham and Women's Hospital and Department of 
      Medicine, Harvard Medical School, Boston, MA 02115, USA.
FAU - Stout, Madeleine M
AU  - Stout MM
AD  - Division of Gastroenterology and Nutrition, Boston Children's Hospital and 
      Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
FAU - Schultz, Cornelia
AU  - Schultz C
AD  - Division of Gastroenterology and Nutrition, Boston Children's Hospital and 
      Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
FAU - Dehlink, Eleonora
AU  - Dehlink E
AD  - Division of Gastroenterology and Nutrition, Boston Children's Hospital and 
      Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
FAU - Shade, Kai-Ting C
AU  - Shade KC
AD  - Center for Immunology and Inflammatory Diseases, Division of Rheumatology, 
      Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, 
      Boston, MA 02129, USA.
FAU - Anthony, Robert M
AU  - Anthony RM
AD  - Center for Immunology and Inflammatory Diseases, Division of Rheumatology, 
      Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, 
      Boston, MA 02129, USA.
FAU - Blumberg, Richard S
AU  - Blumberg RS
AD  - Division of Gastroenterology, Brigham and Women's Hospital and Department of 
      Medicine, Harvard Medical School, Boston, MA 02115, USA.
FAU - Turley, Shannon J
AU  - Turley SJ
AD  - Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, 
      MA 02115, USA.
FAU - Fiebiger, Edda
AU  - Fiebiger E
AD  - Division of Gastroenterology and Nutrition, Boston Children's Hospital and 
      Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. 
      Electronic address: edda.fiebiger@childrens.harvard.edu.
LA  - eng
GR  - R01 DK074500/DK/NIDDK NIH HHS/United States
GR  - R21 CA182598/CA/NCI NIH HHS/United States
GR  - P30 DK043351/DK/NIDDK NIH HHS/United States
GR  - R01 DK053056/DK/NIDDK NIH HHS/United States
GR  - T32 CA070083/CA/NCI NIH HHS/United States
GR  - F32 DK081256/DK/NIDDK NIH HHS/United States
GR  - P30 DK034854/DK/NIDDK NIH HHS/United States
GR  - R01 AI075037/AI/NIAID NIH HHS/United States
GR  - P01 AI045757/AI/NIAID NIH HHS/United States
GR  - R56 AI075037/AI/NIAID NIH HHS/United States
GR  - R56 DK053056/DK/NIDDK NIH HHS/United States
GR  - K01 DK093597/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20150305
PL  - United States
TA  - Cell Rep
JT  - Cell reports
JID - 101573691
PMC - PMC4559493
MID - NIHMS664634
COIS- CONFLICT OF INTEREST: The authors declare no competing financial interests.
EDAT- 2015/03/11 06:00
MHDA- 2015/03/11 06:01
PMCR- 2016/09/03
CRDT- 2015/03/11 06:00
PHST- 2014/09/17 00:00 [received]
PHST- 2014/12/30 00:00 [revised]
PHST- 2015/02/02 00:00 [accepted]
PHST- 2015/03/11 06:00 [pubmed]
PHST- 2015/03/11 06:01 [medline]
PHST- 2015/03/11 06:00 [entrez]
PHST- 2016/09/03 00:00 [pmc-release]
AID - S2211-1247(15)00143-6 [pii]
AID - 10.1016/j.celrep.2015.02.015 [doi]
PST - ppublish
SO  - Cell Rep. 2015 Mar 10;10(9):1487-1495. doi: 10.1016/j.celrep.2015.02.015. Epub 
      2015 Mar 5.