PMID- 25753551
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20240213
IS  - 1532-1983 (Electronic)
IS  - 0261-5614 (Print)
IS  - 0261-5614 (Linking)
VI  - 35
IP  - 1
DP  - 2016 Feb
TI  - Macronutrient intake and body composition changes during anti-tuberculosis 
      therapy in adults.
PG  - 205-212
LID - S0261-5614(15)00050-3 [pii]
LID - 10.1016/j.clnu.2015.02.007 [doi]
AB  - BACKGROUND: Malnutrition is common in patients with active tuberculosis (TB), yet 
      little information is available on serial dietary intake or body composition in 
      TB disease. OBJECTIVE: To evaluate macronutrient intake and body composition in 
      individuals with newly diagnosed TB over time. DESIGN: Adults with active 
      pulmonary TB (n = 191; 23 with multidrug resistant TB (MDR-TB) and 36 
      culture-negative household contacts (controls) enrolled in a clinical trial of 
      high-dose cholecalciferol (vitamin D3) were studied. Macronutrient intake was 
      determined at baseline, 8 and 16 weeks. Serial body composition was assessed by 
      body mass index (BMI; kg/m(2)) and bioelectrical impedance analysis (BIA) to 
      estimate fat mass and fat-free mass. Descriptive statistics, repeated measures 
      ANOVA for changes over time and linear regression were used. RESULTS: At 
      baseline, mean daily energy, protein, fat and carbohydrate (CHO) intakes were 
      significantly higher, and body weight, BMI, fat-free mass and fat mass were 
      significantly lower, between TB subjects and controls. These remained significant 
      after adjusting for age, gender, employment status and smoking. In all TB 
      subjects, baseline mean daily intakes of energy, fat and protein were adequate 
      when compared to the US Dietary Reference Intakes and protein significantly 
      increased over time (p < 0.0001). Body weight, BMI, and fat and fat-free mass 
      increased over time. MDR-TB patients exhibited lower body weight and fat-free 
      mass over time, despite similar daily intake of kcal, protein, and fat. 
      CONCLUSIONS: Macronutrient intake was higher in TB patients than controls, but 
      TB-induced wasting was evident. As macronutrient intake of TB subjects increased 
      over time, there was a parallel increase in BMI, while body composition 
      proportions were maintained. However, individuals with MDR-TB demonstrated 
      concomitantly decreased body weight and fat-free mass over time versus 
      drug-sensitive TB patients, despite increased macronutrient intake. Thus, MDR-TB 
      appears to blunt anabolism to macronutrient intake, likely reflecting the 
      catabolic effects of TB.
CI  - Copyright (c) 2015 Elsevier Ltd and European Society for Clinical Nutrition and 
      Metabolism. All rights reserved.
FAU - Frediani, Jennifer K
AU  - Frediani JK
AD  - Graduate Division of Biological and Biomedical Sciences, Nutrition and Health 
      Sciences Graduate Program, Laney Graduate School, Emory University, Atlanta, GA 
      30322, United States; Division of Endocrinology, Metabolism and Lipids, 
      Department of Medicine, Emory University School of Medicine, Atlanta, GA, United 
      States; Center for Clinical and Molecular Nutrition, Department of Medicine, 
      Emory University School of Medicine, Atlanta, GA 30322, United States.
FAU - Sanikidze, Ekaterina
AU  - Sanikidze E
AD  - National Center for Tuberculosis and Lung Disease, Tbilisi, Georgia.
FAU - Kipiani, Maia
AU  - Kipiani M
AD  - National Center for Tuberculosis and Lung Disease, Tbilisi, Georgia.
FAU - Tukvadze, Nestani
AU  - Tukvadze N
AD  - National Center for Tuberculosis and Lung Disease, Tbilisi, Georgia.
FAU - Hebbar, Gautam
AU  - Hebbar G
AD  - Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory 
      University School of Medicine, Atlanta, GA, United States; Center for Clinical 
      and Molecular Nutrition, Department of Medicine, Emory University School of 
      Medicine, Atlanta, GA 30322, United States.
FAU - Ramakrishnan, Usha
AU  - Ramakrishnan U
AD  - Graduate Division of Biological and Biomedical Sciences, Nutrition and Health 
      Sciences Graduate Program, Laney Graduate School, Emory University, Atlanta, GA 
      30322, United States; Center for Clinical and Molecular Nutrition, Department of 
      Medicine, Emory University School of Medicine, Atlanta, GA 30322, United States; 
      Hubert Department of Global Health, Rollins School of Public Health, Emory 
      University, Atlanta, GA 30322, United States.
FAU - Jones, Dean P
AU  - Jones DP
AD  - Graduate Division of Biological and Biomedical Sciences, Nutrition and Health 
      Sciences Graduate Program, Laney Graduate School, Emory University, Atlanta, GA 
      30322, United States; Center for Clinical and Molecular Nutrition, Department of 
      Medicine, Emory University School of Medicine, Atlanta, GA 30322, United States; 
      Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Emory 
      University School of Medicine, Atlanta, GA 30322, United States.
FAU - Easley, Kirk A
AU  - Easley KA
AD  - Department of Biostatistics and Bioinformatics, Rollins School of Public Health, 
      Emory University, Atlanta, GA 30322, United States.
FAU - Shenvi, Neeta
AU  - Shenvi N
AD  - Department of Biostatistics and Bioinformatics, Rollins School of Public Health, 
      Emory University, Atlanta, GA 30322, United States.
FAU - Kempker, Russell R
AU  - Kempker RR
AD  - Division of Infectious Diseases, Department of Medicine, Emory University School 
      of Medicine, Atlanta, GA 30322, United States.
FAU - Tangpricha, Vin
AU  - Tangpricha V
AD  - Graduate Division of Biological and Biomedical Sciences, Nutrition and Health 
      Sciences Graduate Program, Laney Graduate School, Emory University, Atlanta, GA 
      30322, United States; Division of Endocrinology, Metabolism and Lipids, 
      Department of Medicine, Emory University School of Medicine, Atlanta, GA, United 
      States; Center for Clinical and Molecular Nutrition, Department of Medicine, 
      Emory University School of Medicine, Atlanta, GA 30322, United States.
FAU - Blumberg, Henry M
AU  - Blumberg HM
AD  - Hubert Department of Global Health, Rollins School of Public Health, Emory 
      University, Atlanta, GA 30322, United States; Division of Infectious Diseases, 
      Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, 
      United States.
FAU - Ziegler, Thomas R
AU  - Ziegler TR
AD  - Graduate Division of Biological and Biomedical Sciences, Nutrition and Health 
      Sciences Graduate Program, Laney Graduate School, Emory University, Atlanta, GA 
      30322, United States; Division of Endocrinology, Metabolism and Lipids, 
      Department of Medicine, Emory University School of Medicine, Atlanta, GA, United 
      States; Center for Clinical and Molecular Nutrition, Department of Medicine, 
      Emory University School of Medicine, Atlanta, GA 30322, United States. Electronic 
      address: tzieg01@emory.edu.
LA  - eng
GR  - K24 DK096574/DK/NIDDK NIH HHS/United States
GR  - K23 AR054334/AR/NIAMS NIH HHS/United States
GR  - P01 ES016731/ES/NIEHS NIH HHS/United States
GR  - D43 TW007124/TW/FIC NIH HHS/United States
GR  - UL1 TR000454/TR/NCATS NIH HHS/United States
GR  - K23 AI103044/AI/NIAID NIH HHS/United States
GR  - R01 ES016731/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150226
PL  - England
TA  - Clin Nutr
JT  - Clinical nutrition (Edinburgh, Scotland)
JID - 8309603
RN  - 0 (Antitubercular Agents)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Dietary Proteins)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Adult
MH  - Antitubercular Agents/administration & dosage/*therapeutic use
MH  - *Body Composition
MH  - Body Mass Index
MH  - Body Weight
MH  - Dietary Carbohydrates/administration & dosage/analysis
MH  - Dietary Fats/administration & dosage/analysis
MH  - Dietary Proteins/administration & dosage/analysis
MH  - Dose-Response Relationship, Drug
MH  - Double-Blind Method
MH  - Electric Impedance
MH  - *Energy Intake
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Malnutrition/*blood
MH  - Middle Aged
MH  - Nutrition Assessment
MH  - Tuberculosis, Multidrug-Resistant/*complications/drug therapy
MH  - Vitamin D/administration & dosage/analysis
MH  - Young Adult
PMC - PMC4550569
MID - NIHMS667678
OTO - NOTNLM
OT  - Body composition
OT  - Diet
OT  - Macronutrient
OT  - Tuberculosis
EDAT- 2015/03/11 06:00
MHDA- 2016/12/15 06:00
PMCR- 2017/02/01
CRDT- 2015/03/11 06:00
PHST- 2014/11/04 00:00 [received]
PHST- 2015/01/27 00:00 [revised]
PHST- 2015/02/14 00:00 [accepted]
PHST- 2015/03/11 06:00 [entrez]
PHST- 2015/03/11 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PHST- 2017/02/01 00:00 [pmc-release]
AID - S0261-5614(15)00050-3 [pii]
AID - 10.1016/j.clnu.2015.02.007 [doi]
PST - ppublish
SO  - Clin Nutr. 2016 Feb;35(1):205-212. doi: 10.1016/j.clnu.2015.02.007. Epub 2015 Feb 
      26.