PMID- 25754501
OWN - NLM
STAT- MEDLINE
DCOM- 20160412
LR  - 20221207
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 29
IP  - 4
DP  - 2015 May-Jun
TI  - Serum angiopoietin-2 is associated with angiopathy in type 2 diabetes mellitus.
PG  - 568-71
LID - S1056-8727(15)00053-7 [pii]
LID - 10.1016/j.jdiacomp.2015.02.006 [doi]
AB  - PURPOSE: The aim of the present study was to investigate the association of serum 
      levels of angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) with angiopathy in 
      type 2 diabetes mellitus (T2DM). METHODS: The group studied comprised of 120 
      patients with T2DM (68 males and 52 females), included macroangiopathy 
      complications, microvascular disease and diabetic without vascular disease. The 
      control group consisted of 50 healthy blood donors. Ang-1, Ang-2, fasting plasma 
      glucose (FBG), fasting insulin (FINS) and HbA1c were assessed. RESULTS: The serum 
      Ang-2 levels of T2DM patients with angiopathy were found to be significantly 
      higher compared to patients without angiopathy. Ang-2 levels were significantly 
      positively correlated with homeostasis model assessment for insulin resistance 
      (HOMA-IR) and glycosylated hemoglobin A1c (HbA1c) (r=0.577 and 0.504, 
      respectively, P<0.01). In contrast, there was no significant correlation between 
      Ang-1 levels and HOMA-IR (P>0.05). In multivariable logistic regression analysis, 
      Ang-2 levels (P=0.02) were found to be independently associated with patients 
      with T2DM angiopathy. CONCLUSIONS: An association between the Ang-2 and T2DM with 
      vascular complications was found.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Li, Li
AU  - Li L
AD  - Department of Clinical Laboratory, Binhai Hospital, Jiangsu Province, P.R. China.
FAU - Qian, Lei
AU  - Qian L
AD  - Department of Clinical Laboratory, Binhai Hospital, Jiangsu Province, P.R. China. 
      Electronic address: lili5898@126.com.
FAU - Yu, Zheng-Qing
AU  - Yu ZQ
AD  - Department of Clinical Laboratory, Binhai Hospital, Jiangsu Province, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20150220
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (ANGPT2 protein, human)
RN  - 0 (Angiopoietin-2)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Aged
MH  - Angiopoietin-2/*blood/metabolism
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*blood/*complications/metabolism
MH  - Diabetic Angiopathies/*blood/metabolism
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Insulin Resistance
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - Angiopoietin-1
OT  - Angiopoietin-2
OT  - Diabetes mellitus
OT  - Glycosylated hemoglobin
OT  - Vascular complications
EDAT- 2015/03/11 06:00
MHDA- 2016/04/14 06:00
CRDT- 2015/03/11 06:00
PHST- 2014/11/06 00:00 [received]
PHST- 2015/02/09 00:00 [revised]
PHST- 2015/02/13 00:00 [accepted]
PHST- 2015/03/11 06:00 [entrez]
PHST- 2015/03/11 06:00 [pubmed]
PHST- 2016/04/14 06:00 [medline]
AID - S1056-8727(15)00053-7 [pii]
AID - 10.1016/j.jdiacomp.2015.02.006 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2015 May-Jun;29(4):568-71. doi: 
      10.1016/j.jdiacomp.2015.02.006. Epub 2015 Feb 20.