PMID- 25754580
OWN - NLM
STAT- MEDLINE
DCOM- 20160909
LR  - 20190116
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 56
IP  - 11
DP  - 2015
TI  - Fluorescence in situ hybridization of TP53 for the detection of chromosome 17 
      abnormalities in myelodysplastic syndromes.
PG  - 3183-8
LID - 10.3109/10428194.2015.1028053 [doi]
AB  - Conventional G-banding cytogenetics (CC) detects chromosome 17 (chr17) 
      abnormalities in 2% of patients with de novo myelodysplastic syndromes (MDS). We 
      used CC and fluorescence in situ hybridization (FISH) (LSI p53/17p13.1) to assess 
      deletion of 17p in 531 patients with de novo MDS from the Spanish Group of 
      Hematological Cytogenetics. FISH detected - 17 or 17p abnormalities in 13 cases 
      (2.6%) in whom no 17p abnormalities were revealed by CC: 0.9% of patients with a 
      normal karyotype, 0% in non-informative cytogenetics, 50% of patients with a 
      chr17 abnormality without loss of 17p and 4.7% of cases with an abnormal 
      karyotype not involving chr17. Our results suggest that applying FISH of 17p13 to 
      identify the number of copies of the TP53 gene could be beneficial in patients 
      with a complex karyotype. We recommend using FISH of 17p13 in young patients with 
      a normal karyotype or non-informative cytogenetics, and always in isolated 
      del(17p).
FAU - Sanchez-Castro, Judit
AU  - Sanchez-Castro J
AD  - a Hospital Arnau de Vilanova , Lleida , Spain.
FAU - Marco-Betes, Victor
AU  - Marco-Betes V
AD  - a Hospital Arnau de Vilanova , Lleida , Spain.
FAU - Gomez-Arbones, Xavier
AU  - Gomez-Arbones X
AD  - a Hospital Arnau de Vilanova , Lleida , Spain.
AD  - b Universitat de Lleida , Lleida , Spain.
FAU - Garcia-Cerecedo, Tomas
AU  - Garcia-Cerecedo T
AD  - a Hospital Arnau de Vilanova , Lleida , Spain.
FAU - Lopez, Ricard
AU  - Lopez R
AD  - a Hospital Arnau de Vilanova , Lleida , Spain.
FAU - Talavera, Elisabeth
AU  - Talavera E
AD  - a Hospital Arnau de Vilanova , Lleida , Spain.
FAU - Fernandez-Ruiz, Sara
AU  - Fernandez-Ruiz S
AD  - c Institut de Recerca contra la Leucemia Josep Carreras (IJC) , Badalona, 
      Barcelona , Spain.
FAU - Adema, Vera
AU  - Adema V
AD  - c Institut de Recerca contra la Leucemia Josep Carreras (IJC) , Badalona, 
      Barcelona , Spain.
FAU - Marugan, Isabel
AU  - Marugan I
AD  - d Hospital Clinico Universitario de Valencia , Valencia , Spain.
FAU - Luno, Elisa
AU  - Luno E
AD  - e Hospital Universitario Central de Asturias , Oviedo , Spain.
FAU - Sanzo, Carmen
AU  - Sanzo C
AD  - e Hospital Universitario Central de Asturias , Oviedo , Spain.
FAU - Vallespi, Teresa
AU  - Vallespi T
AD  - f Hospital Vall d'Hebron , Barcelona , Spain.
FAU - Arenillas, Leonor
AU  - Arenillas L
AD  - g Hospital del Mar , Barcelona , Spain.
FAU - Marco Buades, Josefa
AU  - Marco Buades J
AD  - h Hospital General de Castellon , Castellon , Spain.
FAU - Batlle, Ana
AU  - Batlle A
AD  - i Hospital Universitario Marques de Valdecilla , Santander , Spain.
FAU - Buno, Ismael
AU  - Buno I
AD  - j Hospital General Universitario Gregorio Maranon , Madrid , Spain.
FAU - Martin Ramos, Maria Luisa
AU  - Martin Ramos ML
AD  - k Hospital Universitario 12 de Octubre , Madrid , Spain.
FAU - Blazquez Rios, Beatriz
AU  - Blazquez Rios B
AD  - l Hospital de Basurto , Bilbao , Spain.
FAU - Collado Nieto, Rosa
AU  - Collado Nieto R
AD  - m Hospital General Universitario de Valencia , Valencia , Spain.
FAU - Vargas, Ma Teresa
AU  - Vargas MT
AD  - n Hospital Universitario Virgen Macarena , Sevilla , Spain.
FAU - Gonzalez Martinez, Teresa
AU  - Gonzalez Martinez T
AD  - o Fundacion Publica Galega Medicina Xenomica, Hospital Clinico Universitario , 
      Santiago , Spain.
FAU - Sanz, Guillermo
AU  - Sanz G
AD  - p Hospital Universitari i Politecnic La Fe , Valencia , Spain.
FAU - Sole, Francesc
AU  - Sole F
AD  - c Institut de Recerca contra la Leucemia Josep Carreras (IJC) , Badalona, 
      Barcelona , Spain.
CN  - Spanish Group for Mds Study (GESMD)
CN  - Spanish Group for Clinical Cytogenetics (Gcecgh)
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20150512
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Chromosome Banding
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 17
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Myelodysplastic Syndromes/*genetics
MH  - Tumor Suppressor Protein p53/*genetics
OTO - NOTNLM
OT  - FISH
OT  - Myelodysplastic syndromes
OT  - chromosome 17
OT  - cytogenetics
EDAT- 2015/03/11 06:00
MHDA- 2016/09/10 06:00
CRDT- 2015/03/11 06:00
PHST- 2015/03/11 06:00 [entrez]
PHST- 2015/03/11 06:00 [pubmed]
PHST- 2016/09/10 06:00 [medline]
AID - 10.3109/10428194.2015.1028053 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2015;56(11):3183-8. doi: 10.3109/10428194.2015.1028053. Epub 2015 
      May 12.