PMID- 25754584
OWN - NLM
STAT- MEDLINE
DCOM- 20160328
LR  - 20191210
IS  - 1532-8430 (Electronic)
IS  - 0022-0736 (Linking)
VI  - 48
IP  - 4
DP  - 2015 Jul-Aug
TI  - Measurements of electrical and mechanical dyssynchrony are both essential to 
      improve prediction of CRT response.
PG  - 601-8
LID - S0022-0736(15)00048-5 [pii]
LID - 10.1016/j.jelectrocard.2015.01.015 [doi]
AB  - INTRODUCTION: Predicting reverse remodeling after cardiac resynchronization 
      therapy (CRT) remains challenging and different etiologies of heart failure might 
      hamper identification of predictors. OBJECTIVE: Assess the incremental value of 
      mechanical dyssynchrony besides electrical dyssynchrony for predicting CRT 
      response. METHODS: 227 patients (51% ischemic) received CRT. Response was defined 
      as >/=15% left ventricular end systolic volume decrease after six months. 
      Prediction models were developed comprising clinical parameters and electrical 
      dyssynchrony (Model A), subsequently complemented with mechanical dyssynchrony 
      (Model B). Models were compared by area under the receiver-operating curve (AUC), 
      net reclassification index (NRI) and integrated discrimination improvement (IDI) 
      for the complete cohort, ischemic (ICM) and non-ischemic (NICM) subpopulations. 
      RESULTS: Model B performed significantly better than Model A supported by AUC, 
      NRI and IDI. Furthermore, model B significantly better predicted response for 
      NICM than ICM. CONCLUSION: Electrical dyssynchrony and mechanical dyssynchrony 
      are essential to predict CRT response. Nevertheless, response prediction for ICM 
      remains challenging.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Van't Sant, J
AU  - Van't Sant J
AD  - Department of Cardiology, University Medical Center Utrecht, Utrecht, The 
      Netherlands. Electronic address: j.vantsant@umcutrecht.nl.
FAU - Ter Horst, I A H
AU  - Ter Horst IA
AD  - Department of Cardiology, University Medical Center Utrecht, Utrecht, The 
      Netherlands.
FAU - Wijers, S C
AU  - Wijers SC
AD  - Department of Cardiology, University Medical Center Utrecht, Utrecht, The 
      Netherlands.
FAU - Mast, T P
AU  - Mast TP
AD  - Department of Cardiology, University Medical Center Utrecht, Utrecht, The 
      Netherlands.
FAU - Leenders, G E
AU  - Leenders GE
AD  - Department of Cardiology, University Medical Center Utrecht, Utrecht, The 
      Netherlands.
FAU - Doevendans, P A
AU  - Doevendans PA
AD  - Department of Cardiology, University Medical Center Utrecht, Utrecht, The 
      Netherlands.
FAU - Cramer, M J
AU  - Cramer MJ
AD  - Department of Cardiology, University Medical Center Utrecht, Utrecht, The 
      Netherlands.
FAU - Meine, M
AU  - Meine M
AD  - Department of Cardiology, University Medical Center Utrecht, Utrecht, The 
      Netherlands.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20150202
PL  - United States
TA  - J Electrocardiol
JT  - Journal of electrocardiology
JID - 0153605
SB  - IM
MH  - Aged
MH  - *Defibrillators, Implantable
MH  - Diagnosis, Computer-Assisted/methods
MH  - Echocardiography/methods
MH  - Electrocardiography/*methods
MH  - Female
MH  - Heart Failure/complications/*diagnosis/*therapy
MH  - Humans
MH  - Male
MH  - Outcome Assessment, Health Care/methods
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Stroke Volume
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/complications/*diagnosis/*therapy
OTO - NOTNLM
OT  - Cardiac resynchronization therapy
OT  - Electrical dyssynchrony
OT  - Mechanical dyssynchrony
EDAT- 2015/03/11 06:00
MHDA- 2016/03/29 06:00
CRDT- 2015/03/11 06:00
PHST- 2014/11/12 00:00 [received]
PHST- 2015/03/11 06:00 [entrez]
PHST- 2015/03/11 06:00 [pubmed]
PHST- 2016/03/29 06:00 [medline]
AID - S0022-0736(15)00048-5 [pii]
AID - 10.1016/j.jelectrocard.2015.01.015 [doi]
PST - ppublish
SO  - J Electrocardiol. 2015 Jul-Aug;48(4):601-8. doi: 
      10.1016/j.jelectrocard.2015.01.015. Epub 2015 Feb 2.