PMID- 25755176
OWN - NLM
STAT- MEDLINE
DCOM- 20160419
LR  - 20191210
IS  - 1942-7611 (Electronic)
IS  - 1942-7603 (Linking)
VI  - 7
IP  - 5
DP  - 2015 May
TI  - Chemiluminescence detection of MDMA in street drug samples using 
      tris(2,2'-bipyridine)ruthenium(III).
PG  - 428-32
LID - 10.1002/dta.1780 [doi]
AB  - Tris(2,2'-bipyridine)ruthenium(II) chemiluminescence was investigated for the 
      detection of 3,4-methylenedioxymethamphetamine (MDMA) and several related 
      compounds in street drug samples. Optimization using flow injection analysis 
      showed that the selectivity of the reagent can be targeted towards the detection 
      of secondary amines by altering the pH of the reaction environment. The greater 
      selectivity of this mode of detection, compared to UV-absorbance, reduces the 
      probability of false positive results from interfering compounds. The detection 
      limit for MDMA under these conditions was 0.48 muM. A HPLC method incorporating 
      post-column tris(2,2'-bipyridine)ruthenium(II) chemiluminescence detection was 
      applied to the determination of MDMA in five street drug samples. The results 
      obtained were in good agreement with quantification performed using traditional 
      UV-absorbance detection, which demonstrates the viability of this method for 
      confirmatory analysis of drug samples. This is the first report of 
      tris(2,2'-bipyridine)ruthenium(II) chemiluminescence for the detection of MDMA 
      and related amphetamine derivatives.
CI  - Copyright (c) 2015 John Wiley & Sons, Ltd.
FAU - Theakstone, Ashton G
AU  - Theakstone AG
AD  - Centre for Chemistry and Biotechnology, School of Life and Environmental 
      Sciences, Faculty of Science, Engineering and Built Environment, Deakin 
      University, Geelong, Victoria, 3216, Australia.
FAU - Smith, Zoe M
AU  - Smith ZM
AD  - Centre for Chemistry and Biotechnology, School of Life and Environmental 
      Sciences, Faculty of Science, Engineering and Built Environment, Deakin 
      University, Geelong, Victoria, 3216, Australia.
FAU - Terry, Jessica M
AU  - Terry JM
AD  - Centre for Chemistry and Biotechnology, School of Life and Environmental 
      Sciences, Faculty of Science, Engineering and Built Environment, Deakin 
      University, Geelong, Victoria, 3216, Australia.
FAU - Barnett, Neil W
AU  - Barnett NW
AD  - Centre for Chemistry and Biotechnology, School of Life and Environmental 
      Sciences, Faculty of Science, Engineering and Built Environment, Deakin 
      University, Geelong, Victoria, 3216, Australia.
FAU - Francis, Paul S
AU  - Francis PS
AD  - Centre for Chemistry and Biotechnology, School of Life and Environmental 
      Sciences, Faculty of Science, Engineering and Built Environment, Deakin 
      University, Geelong, Victoria, 3216, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150309
PL  - England
TA  - Drug Test Anal
JT  - Drug testing and analysis
JID - 101483449
RN  - 0 (Illicit Drugs)
RN  - 0 (Organometallic Compounds)
RN  - 0 (tris(2,2'-bipyridyl)ruthenium(II))
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Humans
MH  - Illicit Drugs/*chemistry
MH  - Limit of Detection
MH  - Luminescent Measurements/*methods
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*analysis
MH  - Organometallic Compounds/*chemistry
MH  - Substance Abuse Detection/methods
OTO - NOTNLM
OT  - MDMA
OT  - amphetamine derivatives
OT  - chemiluminescence detection
OT  - high performance liquid chromatography
OT  - street drug samples
EDAT- 2015/03/11 06:00
MHDA- 2016/04/20 06:00
CRDT- 2015/03/11 06:00
PHST- 2014/12/10 00:00 [received]
PHST- 2015/02/02 00:00 [revised]
PHST- 2015/02/03 00:00 [accepted]
PHST- 2015/03/11 06:00 [entrez]
PHST- 2015/03/11 06:00 [pubmed]
PHST- 2016/04/20 06:00 [medline]
AID - 10.1002/dta.1780 [doi]
PST - ppublish
SO  - Drug Test Anal. 2015 May;7(5):428-32. doi: 10.1002/dta.1780. Epub 2015 Mar 9.