PMID- 25755198
OWN - NLM
STAT- MEDLINE
DCOM- 20151103
LR  - 20181202
IS  - 1930-739X (Electronic)
IS  - 1930-7381 (Linking)
VI  - 23
IP  - 4
DP  - 2015 Apr
TI  - Fitness is a determinant of the metabolic response to endurance training in 
      adolescents at risk of type 2 diabetes mellitus.
PG  - 823-32
LID - 10.1002/oby.21032 [doi]
AB  - OBJECTIVE: The purpose of this prospective cohort study was to determine whether 
      changes in cardiorespiratory fitness are associated with the metabolic response 
      to endurance training in adolescents at risk of type 2 diabetes mellitus (T2DM). 
      METHODS: Seventy-three overweight and obese adolescents completed a 6-month 
      endurance exercise intervention. Total fat mass, trunk fat mass, visceral adipose 
      tissue, and liver fat were assessed with dual energy X-ray absorptiometry and 
      magnetic resonance imaging spectroscopy. RESULTS: The change in cardiorespiratory 
      fitness with training was independently associated with reductions in BMI z-score 
      (beta = -0.09; P = 0.006), total fat mass (beta = -1.40; P = 0.007), trunk fat mass 
      (beta = -0.70; P = 0.01), and liver fat (beta = -1.80; P = 0.053). Adolescents within 
      the highest tertile of change in fitness were 4.67 (95% CI: 1.15-13.73; 
      P = 0.03), 11.90 (95% CI: 2.37-59.77; P = 0.002), and 6.21 (95% CI: 1.14-33.99; 
      P = 0.035) times more likely to experience decreases in body weight, BMI, and 
      liver fat compared with adolescents in the lowest tertile. CONCLUSIONS: The 
      changes in adiposity and hepatic triglyceride content in response to endurance 
      training are significantly related to the increase in cardiorespiratory fitness 
      in adolescents at risk of T2DM.
CI  - (c) 2014 The Obesity Society.
FAU - Senechal, Martin
AU  - Senechal M
AD  - Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada; Department of 
      Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, 
      Winnipeg, Manitoba, Canada.
FAU - Rempel, Meaghan
AU  - Rempel M
FAU - Duhamel, Todd A
AU  - Duhamel TA
FAU - MacIntosh, Andrea C
AU  - MacIntosh AC
FAU - Hay, Jacqueline
AU  - Hay J
FAU - Wicklow, Brandy
AU  - Wicklow B
FAU - Wittmeier, Kristy
AU  - Wittmeier K
FAU - Shen, Garry X
AU  - Shen GX
FAU - McGavock, Jonathan M
AU  - McGavock JM
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150307
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
RN  - 0 (Triglycerides)
SB  - IM
MH  - Absorptiometry, Photon
MH  - Adolescent
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*metabolism/pathology/prevention & control
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - Intra-Abdominal Fat/pathology
MH  - Male
MH  - Pediatric Obesity/complications/*metabolism/pathology
MH  - Physical Endurance/*physiology
MH  - Prospective Studies
MH  - Triglycerides/blood
EDAT- 2015/03/11 06:00
MHDA- 2015/11/04 06:00
CRDT- 2015/03/11 06:00
PHST- 2014/09/05 00:00 [received]
PHST- 2014/12/22 00:00 [accepted]
PHST- 2015/03/11 06:00 [entrez]
PHST- 2015/03/11 06:00 [pubmed]
PHST- 2015/11/04 06:00 [medline]
AID - 10.1002/oby.21032 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2015 Apr;23(4):823-32. doi: 10.1002/oby.21032. Epub 2015 
      Mar 7.