PMID- 25755530
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150310
LR  - 20231110
IS  - 0973-6883 (Print)
IS  - 2213-3453 (Electronic)
IS  - 0973-6883 (Linking)
VI  - 4
IP  - 1
DP  - 2014 Mar
TI  - HLA DRB1 Alleles Discriminate the Manifestation of Autoimmune Hepatitis as Type 1 
      or Type 2 in North Indian Population.
PG  - 14-8
LID - 10.1016/j.jceh.2013.12.002 [doi]
AB  - BACKGROUND: Autoimmune hepatitis is a polygenic disorder of unknown etiology, 
      where genetic factors affect the occurrence and clinical phenotype of the 
      disease. It has been reported as a rare disease entity in the Indian 
      subcontinent. This study was undertaken to investigate the association of HLA 
      alleles with autoimmune hepatitis type 1 and type 2 in north Indian population 
      and to analyze if distinct human leukocyte antigen (HLA) alleles help in 
      characterization of the subtypes of autoimmune hepatitis. METHODS: Sixty-eight 
      patients with autoimmune hepatitis and 128 healthy controls were recruited in the 
      study. Out of 68 patients, 55 were diagnosed with autoimmune hepatitis type 1 and 
      13 with autoimmune hepatitis type 2. The patients and the controls were typed for 
      HLA class II alleles by PCR-SSP method. RESULTS: HLA DRB1*04 and DRB1*08 were 
      found to be significantly associated with autoimmune hepatitis type 1 in north 
      Indian population. It was also observed that DRB1*04, DRB1*13 were significantly 
      associated with pediatric autoimmune hepatitis type 1 and DRB1*08 was 
      significantly associated with adult autoimmune hepatitis type 1. DRB1*14 was 
      significantly associated with autoimmune hepatitis type 2. CONCLUSION: The study 
      indicates that autoimmune hepatitis in north Indian population is associated with 
      HLA alleles that may help to discriminate the subtypes as autoimmune hepatitis 
      type 1 and type 2. The study also highlights the ethnic variations in the Indian 
      subcontinent in context to the genetic association of HLA with autoimmune 
      diseases.
FAU - Kaur, Navchetan
AU  - Kaur N
AD  - Department of Immunopathology, Post Graduate Institute of Medical Education and 
      Research, Chandigarh 160012, India.
FAU - Minz, Ranjana W
AU  - Minz RW
AD  - Department of Immunopathology, Post Graduate Institute of Medical Education and 
      Research, Chandigarh 160012, India.
FAU - Anand, Shashi
AU  - Anand S
AD  - Department of Immunopathology, Post Graduate Institute of Medical Education and 
      Research, Chandigarh 160012, India.
FAU - Saikia, Biman
AU  - Saikia B
AD  - Department of Immunopathology, Post Graduate Institute of Medical Education and 
      Research, Chandigarh 160012, India.
FAU - Aggarwal, Ritu
AU  - Aggarwal R
AD  - Department of Immunopathology, Post Graduate Institute of Medical Education and 
      Research, Chandigarh 160012, India.
FAU - Das, Ashim
AU  - Das A
AD  - Department of Histopathology, Post Graduate Institute of Medical Education and 
      Research, Chandigarh 160012, India.
FAU - Thapa, Babu R
AU  - Thapa BR
AD  - Department of Paediatric Gastroenterology, Post Graduate Institute of Medical 
      Education and Research, Chandigarh 160012, India.
FAU - Chawla, Yogesh K
AU  - Chawla YK
AD  - Department of Hepatology, Post Graduate Institute of Medical Education and 
      Research, Chandigarh 160012, India.
LA  - eng
PT  - Journal Article
DEP - 20131216
PL  - India
TA  - J Clin Exp Hepatol
JT  - Journal of clinical and experimental hepatology
JID - 101574137
PMC - PMC4017209
OTO - NOTNLM
OT  - AASLD, American Association for the Study of the Liver
OT  - AIH, autoimmune hepatitis
OT  - ANA, antinuclear antibody
OT  - ASMA, anti smooth muscle antibody
OT  - CI, confidence interval
OT  - HLA, human leukocyte antigen
OT  - IAHG, International Autoimmune Hepatitis Group
OT  - IIF, indirect immuno florescence
OT  - LKM, liver kidney microsomal
OT  - MHC, major histocompatibility complex
OT  - Mb, megabase
OT  - OR, odds ratio
OT  - PCR-SSP, polymerase chain reaction-sequence specific primers
OT  - RR, relative risk
OT  - autoimmune hepatitis
OT  - ethnic variations
OT  - human leukocyte antigen
OT  - north India
EDAT- 2015/03/11 06:00
MHDA- 2015/03/11 06:01
PMCR- 2013/12/16
CRDT- 2015/03/11 06:00
PHST- 2013/09/10 00:00 [received]
PHST- 2013/12/02 00:00 [accepted]
PHST- 2015/03/11 06:00 [entrez]
PHST- 2015/03/11 06:00 [pubmed]
PHST- 2015/03/11 06:01 [medline]
PHST- 2013/12/16 00:00 [pmc-release]
AID - S0973-6883(13)00675-0 [pii]
AID - 10.1016/j.jceh.2013.12.002 [doi]
PST - ppublish
SO  - J Clin Exp Hepatol. 2014 Mar;4(1):14-8. doi: 10.1016/j.jceh.2013.12.002. Epub 
      2013 Dec 16.