PMID- 25755711
OWN - NLM
STAT- MEDLINE
DCOM- 20151201
LR  - 20190221
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 8
IP  - 1
DP  - 2015
TI  - Overexpression of ROCK1 and ROCK2 inhibits human laryngeal squamous cell 
      carcinoma.
PG  - 244-51
AB  - Rho-associated coiled-coil containing protein kinase (ROCK) over-expression has 
      been implicated in the progression of many tumor types. The aim of this study was 
      to explore the roles of ROCK1 and ROCK2 in human laryngeal squamous cell 
      carcinoma (LSCC). ROCK1 and ROCK2 expression levels were examined in 50 cases of 
      human LSCC samples by immunohistochemistry. Effects of ROCK1 and ROCK2 on LSCC 
      cell proliferation and motility were investigated in the presence of the ROCK 
      inhibitor Y-27632. The results showed that ROCK1 expression was positively 
      correlated with tumor size and lymph node metastasis (P < 0.05); ROCK2 positively 
      correlated with tumor size (P < 0.05). Inhibition of ROCK1 and ROCK2 by Y-27632 
      significantly inhibits proliferation, migration, and invasion of LSCC cells. Our 
      data indicate that expression of ROCK1 and ROCK2 are closely associated with 
      tumor growth and lymph node metastasis of LSCC. Thus, these two ROCK isoforms may 
      be useful as molecular makers for LSCC diagnosis and may be useful therapeutic 
      targets as well.
FAU - Zhang, Junbo
AU  - Zhang J
AD  - Department of Otolaryngology, Head and Neck Surgery, Peking University First 
      Hospital Beijing 100034, China.
FAU - He, Xue
AU  - He X
AD  - Department of Otolaryngology, Head and Neck Surgery, Chinese PLA General Hospital 
      Beijing 100853, China.
FAU - Ma, Yueying
AU  - Ma Y
AD  - Department of Otolaryngology, Head and Neck Surgery, Beijing Friendship Hospital, 
      Capital Medical University Beijing 100050, China.
FAU - Liu, Yanli
AU  - Liu Y
AD  - Department of Otolaryngology, Head and Neck Surgery, Chinese PLA General Hospital 
      Beijing 100853, China.
FAU - Shi, Huaiyin
AU  - Shi H
AD  - Department of Pathology, Chinese PLA General Hospital Beijing 100853, China.
FAU - Guo, Weiwei
AU  - Guo W
AD  - Department of Otolaryngology, Head and Neck Surgery, Chinese PLA General Hospital 
      Beijing 100853, China.
FAU - Liu, Liangfa
AU  - Liu L
AD  - Department of Otolaryngology, Head and Neck Surgery, Beijing Friendship Hospital, 
      Capital Medical University Beijing 100050, China.
LA  - eng
PT  - Journal Article
DEP - 20150101
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - EC 2.7.11.1 (ROCK1 protein, human)
RN  - EC 2.7.11.1 (ROCK2 protein, human)
RN  - EC 2.7.11.1 (rho-Associated Kinases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/enzymology/mortality/*pathology
MH  - Cell Line, Tumor
MH  - Female
MH  - Head and Neck Neoplasms/enzymology/mortality/*pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Kaplan-Meier Estimate
MH  - Laryngeal Neoplasms/enzymology/mortality/*pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Invasiveness/pathology
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Up-Regulation
MH  - rho-Associated Kinases/*biosynthesis
PMC - PMC4348933
OTO - NOTNLM
OT  - Laryngeal squamous cell carcinoma
OT  - ROCK
OT  - Y-27632
OT  - lymph node metastasis
OT  - tumor growth
EDAT- 2015/03/11 06:00
MHDA- 2015/12/15 06:00
PMCR- 2015/01/01
CRDT- 2015/03/11 06:00
PHST- 2014/10/27 00:00 [received]
PHST- 2014/12/22 00:00 [accepted]
PHST- 2015/03/11 06:00 [entrez]
PHST- 2015/03/11 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2015 Jan 1;8(1):244-51. eCollection 2015.