PMID- 2575731
OWN - NLM
STAT- MEDLINE
DCOM- 19900314
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 107
IP  - 1-3
DP  - 1989 Dec 15
TI  - Quisqualate and N-methyl-D-aspartate synergistically excite cerebellar Purkinje 
      cells as a long-term effect.
PG  - 63-9
AB  - Interactions between the excitatory amino acids (EAAs) quisqualate (QUIS) and 
      N-methyl-D-aspartate (NMDA) were investigated in order to explore mechanisms 
      which may help to explain long-term changes in synaptic efficacy induced by these 
      agents. In 93% of the cerebellar Purkinje (Pnj) cells recorded extracellularly 
      which responded to iontophoretic application of QUIS with increases in discharge 
      of up to 100% above spontaneous levels. NMDA administration sensitized the neuron 
      to further QUIS stimulation by 40-200% over control levels of response. 
      NMDA-enhanced QUIS responses reached maximal levels after termination of NMDA 
      application and persisted for up to 2 h post-NMDA. The NMDA receptor blocker 
      2-amino-5-phosphonovalerate (APV) prevented the observed effect only when 
      administered before but not after NMDA application, suggesting that a 
      long-lasting post-receptor mechanism may be involved in the observed synergistic 
      interaction of QUIS and NMDA.
FAU - Smith, S S
AU  - Smith SS
AD  - Department of Anatomy, Hahnemann University, Philadelphia, PA 19102-1192.
LA  - eng
GR  - NS25809/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Oxadiazoles)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 76726-92-6 (2-Amino-5-phosphonovalerate)
RN  - 8OC22C1B99 (Quisqualic Acid)
SB  - IM
MH  - 2-Amino-5-phosphonovalerate/pharmacology
MH  - Action Potentials/drug effects
MH  - Animals
MH  - Aspartic Acid/*analogs & derivatives/pharmacology
MH  - Female
MH  - N-Methylaspartate
MH  - Oxadiazoles/*pharmacology
MH  - Purkinje Cells/drug effects/*physiology
MH  - Quisqualic Acid
MH  - Rats
EDAT- 1989/12/15 00:00
MHDA- 1989/12/15 00:01
CRDT- 1989/12/15 00:00
PHST- 1989/12/15 00:00 [pubmed]
PHST- 1989/12/15 00:01 [medline]
PHST- 1989/12/15 00:00 [entrez]
AID - 0304-3940(89)90791-X [pii]
AID - 10.1016/0304-3940(89)90791-x [doi]
PST - ppublish
SO  - Neurosci Lett. 1989 Dec 15;107(1-3):63-9. doi: 10.1016/0304-3940(89)90791-x.