PMID- 25758878
OWN - NLM
STAT- MEDLINE
DCOM- 20150527
LR  - 20191113
IS  - 1319-2442 (Print)
IS  - 1319-2442 (Linking)
VI  - 26
IP  - 2
DP  - 2015 Mar
TI  - Non-tolerability of double-filtration plasmapheresis in antibody-incompatible 
      kidney transplant candidates.
PG  - 297-301
AB  - Few studies have reported the use of double-filtration plasmapheresis (DFPP) in 
      antibody-incompatible kidney transplantation. To assess the efficiency and 
      tolerability of DFPP, we prospectively studied four chronic hemodialysis patients 
      from two centers undergoing antibody-incompatible kidney transplantation. DFPP 
      was used for ABO-incompatible transplantation (n = 1), for high human leukocyte 
      antigen (HLA) immunization levels (n = 2) or for the presence of a donor-specific 
      antibody (DSA) against a potential living donor (n = 1). In all the patients, the 
      DFPP program was discontinued because of the adverse effects. Low blood pressure 
      occurred during the first hour of the session in all the patients. A significant 
      loss of plasma proteins, clotting factors and immunoglobulins also occurred 
      during this treatment. In addition, fistula thrombosis was diagnosed in two 
      patients. Three patients experienced gastrointestinal symptoms. The DFPP reduced 
      the titers of the anti-B antibodies and reduced the levels of DSA in one patient, 
      but had no effect on anti-HLA antibodies in the remaining two patients. Our study 
      highlights the non-tolerability and poor efficacy of DFPP prior to 
      antibody-incompatible kidney transplantation that limit its extensive use in the 
      desensitization protocols.
FAU - Hebibi, Hadia
AU  - Hebibi H
FAU - Weclawiak, Hugo
AU  - Weclawiak H
FAU - Rostaing, Lionel
AU  - Rostaing L
FAU - Beaudreuil, Severine
AU  - Beaudreuil S
FAU - Allal, Asma
AU  - Allal A
FAU - Francois, Helene
AU  - Francois H
FAU - Durrbach, Antoine
AU  - Durrbach A
FAU - Kamar, Nassim
AU  - Kamar N
AD  - Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil; 
      INSERM U1043, IFR-BMT, CHU Purpan Toulouse, France.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Multicenter Study
PL  - Saudi Arabia
TA  - Saudi J Kidney Dis Transpl
JT  - Saudi journal of kidney diseases and transplantation : an official publication of 
      the Saudi Center for Organ Transplantation, Saudi Arabia
JID - 9436968
RN  - 0 (ABO Blood-Group System)
RN  - 0 (Biomarkers)
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - ABO Blood-Group System/*immunology
MH  - Adult
MH  - Biomarkers/blood
MH  - Blood Group Incompatibility/blood/immunology/*prevention & control
MH  - France
MH  - HLA Antigens/*immunology
MH  - *Histocompatibility
MH  - Humans
MH  - Isoantibodies/*blood
MH  - *Kidney Transplantation
MH  - Male
MH  - Plasmapheresis/*adverse effects/methods
MH  - Prospective Studies
MH  - Treatment Outcome
EDAT- 2015/03/12 06:00
MHDA- 2015/05/28 06:00
CRDT- 2015/03/12 06:00
PHST- 2015/03/12 06:00 [entrez]
PHST- 2015/03/12 06:00 [pubmed]
PHST- 2015/05/28 06:00 [medline]
AID - SaudiJKidneyDisTranspl_2015_26_2_297_152435 [pii]
AID - 10.4103/1319-2442.152435 [doi]
PST - ppublish
SO  - Saudi J Kidney Dis Transpl. 2015 Mar;26(2):297-301. doi: 
      10.4103/1319-2442.152435.