PMID- 25759827
OWN - NLM
STAT- MEDLINE
DCOM- 20151201
LR  - 20220330
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2014
DP  - 2014
TI  - Expression of TNF-alpha, APRIL and BCMA in Behcet's disease.
PG  - 380405
LID - 10.1155/2014/380405 [doi]
LID - 380405
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) is an important proinflammatory 
      cytokine which plays an important role in the immunopathogenesis of Behcet's 
      disease (BD). B cell activating factor (BAFF) and its homolog A proliferation 
      inducing ligand (APRIL) are members of the tumor necrosis factor family. BAFF 
      binds to 3 receptors, B cell activating factor receptor (BAFF-R), transmembrane 
      activator and calcium modulator ligand interactor (TACI), and B cell maturation 
      antigen (BCMA) that are expressed by B cells. OBJECTIVE: Estimation of the serum 
      levels of TNF-alpha, APRIL, BAFF, and BCMA in patients with BD in an effort to 
      evaluate their degree of involvement in the pathogenesis and development of BD. 
      PATIENTS AND METHODS: This study included 30 male patients fulfilling the 
      international study group criteria for the diagnosis of BD. Twenty age-matched 
      healthy male volunteers served as control. Serum samples were used for 
      quantification of TNF-alpha, APRIL, BCMA, BAFF, and hsCRP using ELISA techniques. 
      RESULTS: The mean serum levels of TNF-alpha, APRIL, BCMA, and BAFF were more elevated 
      in cases than in controls in a statistically significant manner (P < 0.001). 
      Positive correlation was observed between hs-CRP and BDCAF (Behcet's disease 
      current activity forum) index (r 0.68, P < 0.001). None of the TNF family members 
      tested was affected by a positive pathergy test. CONCLUSIONS: Patients have 
      significantly higher levels of TNF family members' (TNF-alpha, BAFF, APRIL, and BCMA) 
      compared to controls which might contribute to the pathogenesis of BD.
FAU - Shaker, Olfat G
AU  - Shaker OG
AD  - Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, 
      Cairo University, Giza, Egypt.
FAU - Tawfic, Shereen O
AU  - Tawfic SO
AD  - Department of Dermatology, Faculty of Medicine, Cairo University, Giza, Egypt.
FAU - El-Tawdy, Amira M
AU  - El-Tawdy AM
AD  - Department of Dermatology, Faculty of Medicine, Cairo University, Giza, Egypt.
FAU - El-Komy, Mohamed H M
AU  - El-Komy MH
AD  - Department of Dermatology, Faculty of Medicine, Cairo University, Giza, Egypt.
FAU - El Menyawi, Manal
AU  - El Menyawi M
AD  - Department of Internal Medicine, Kasr Al-Aini Hospital, Faculty of Medicine, 
      Cairo University, Giza, Egypt.
FAU - Heikal, Ahmed A
AU  - Heikal AA
AD  - Department of Internal Medicine, Kasr Al-Aini Hospital, Faculty of Medicine, 
      Cairo University, Giza, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20141105
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (B-Cell Activating Factor)
RN  - 0 (Biomarkers)
RN  - 0 (TNFRSF13B protein, human)
RN  - 0 (TNFSF13B protein, human)
RN  - 0 (Transmembrane Activator and CAML Interactor Protein)
RN  - 0 (Tumor Necrosis Factor Ligand Superfamily Member 13)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 99123-36-1 (bis(3-bis(4-chlorophenyl)methyl-4-dimethylaminophenyl)amine)
RN  - 9N3CBB0BIQ (Diphenylamine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - B-Cell Activating Factor/blood
MH  - B-Lymphocytes/*immunology
MH  - Behcet Syndrome/*diagnosis/immunology
MH  - Biomarkers/*blood
MH  - C-Reactive Protein/metabolism
MH  - Diphenylamine/analogs & derivatives/blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Transmembrane Activator and CAML Interactor Protein/blood
MH  - Tumor Necrosis Factor Ligand Superfamily Member 13/blood
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Young Adult
PMC - PMC4236893
EDAT- 2014/01/01 00:00
MHDA- 2015/12/15 06:00
PMCR- 2014/11/05
CRDT- 2015/03/12 06:00
PHST- 2014/06/26 00:00 [received]
PHST- 2014/09/08 00:00 [revised]
PHST- 2014/09/08 00:00 [accepted]
PHST- 2015/03/12 06:00 [entrez]
PHST- 2014/01/01 00:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2014/11/05 00:00 [pmc-release]
AID - 10.1155/2014/380405 [doi]
PST - ppublish
SO  - J Immunol Res. 2014;2014:380405. doi: 10.1155/2014/380405. Epub 2014 Nov 5.