PMID- 25760525
OWN - NLM
STAT- MEDLINE
DCOM- 20150902
LR  - 20220331
IS  - 1520-6025 (Electronic)
IS  - 0163-3864 (Linking)
VI  - 78
IP  - 4
DP  - 2015 Apr 24
TI  - Antibacterial Biphenanthrenes from the Fibrous Roots of Bletilla striata.
PG  - 939-43
LID - 10.1021/np501012n [doi]
AB  - Four new 9',10'-dihydro-biphenanthrenes, including an unprecedented 1,2'-linked 
      biphenanthrene, 
      4,7,3',5'-tetramethoxy-9',10'-dihydro(1,2'-biphenanthrene)-2,7'-diol (1), a new 
      1,3'-linked biphenanthrene, 
      4,7,7'-trimethoxy-9',10'-dihydro(1,3'-biphenanthrene)-2,2',5'-triol (2), and two 
      new 1,1'-linked biphenanthrenes, 
      4,7,4'-trimethoxy-9',10'-dihydro(1,1'-biphenanthrene)-2,2',7'-triol (3) and 
      4,7,3',5'-tetramethoxy-9',10'-dihydro(1,1'-biphenanthrene)-2,2',7'-triol (4), as 
      well as two known biphenanthrenes (5, 6), were isolated from a 95% ethanol 
      extract of the fibrous roots of Bletilla striata. Their structures were 
      determined by spectroscopic and spectrometric methods. Atropisomerism of these 
      compounds was considered based on their chiral optical properties and potential 
      energy surface scans at the ab initio HF/3-21G level, which revealed their 
      racemic mixture form. Compounds 2-6 showed potent antibacterial activities 
      against six Gram-positive bacterial strains.
FAU - Qian, Chao-Dong
AU  - Qian CD
AD  - daggerZhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, People's 
      Republic of China.
FAU - Jiang, Fu-Sheng
AU  - Jiang FS
AD  - daggerZhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, People's 
      Republic of China.
FAU - Yu, Hang-Su
AU  - Yu HS
AD  - daggerZhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, People's 
      Republic of China.
FAU - Shen, Yong
AU  - Shen Y
AD  - daggerZhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, People's 
      Republic of China.
FAU - Fu, Yu-Hang
AU  - Fu YH
AD  - daggerZhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, People's 
      Republic of China.
FAU - Cheng, Dong-Qing
AU  - Cheng DQ
AD  - daggerZhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, People's 
      Republic of China.
FAU - Gan, Li-She
AU  - Gan LS
AD  - double daggerCollege of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, 
      Hangzhou 310058, People's Republic of China.
FAU - Ding, Zhi-Shan
AU  - Ding ZS
AD  - daggerZhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, People's 
      Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150311
PL  - United States
TA  - J Nat Prod
JT  - Journal of natural products
JID - 7906882
RN  - 0 (1,1'-biphenanthrene)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Phenanthrenes)
SB  - IM
MH  - Anti-Bacterial Agents/chemistry/*isolation & purification/*pharmacology
MH  - Drugs, Chinese Herbal/chemistry/*isolation & purification/*pharmacology
MH  - Gram-Positive Bacteria/drug effects
MH  - Microbial Sensitivity Tests
MH  - Molecular Structure
MH  - Nuclear Magnetic Resonance, Biomolecular
MH  - Orchidaceae/*chemistry
MH  - Phenanthrenes/chemistry/*isolation & purification/*pharmacology
MH  - Rhizome/chemistry
EDAT- 2015/03/12 06:00
MHDA- 2015/09/04 06:00
CRDT- 2015/03/12 06:00
PHST- 2015/03/12 06:00 [entrez]
PHST- 2015/03/12 06:00 [pubmed]
PHST- 2015/09/04 06:00 [medline]
AID - 10.1021/np501012n [doi]
PST - ppublish
SO  - J Nat Prod. 2015 Apr 24;78(4):939-43. doi: 10.1021/np501012n. Epub 2015 Mar 11.