PMID- 2576139
OWN - NLM
STAT- MEDLINE
DCOM- 19900326
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 34
IP  - 3
DP  - 1989 Nov
TI  - The antinociceptive effects of 3,4-methylenedioxymethamphetamine (MDMA) in the 
      rat.
PG  - 497-501
AB  - The antinociceptive effects of MDMA and morphine were examined in rats using the 
      tail-flick and hot-plate analgesiometric tests. MDMA, in the dose range of 
      1.5-6.0 mg/kg IP, produced a dose-dependent elevation in hot-plate latency, but 
      did not elevate tail-flick latency. In contrast, morphine (2-8 mg/kg, IP) 
      produced analgesia on both the tail-flick and hot-plate tests in a dose-dependent 
      manner. Neither the opiate antagonist naltrexone nor the adrenoceptor antagonist 
      phentolamine effectively attenuated MDMA-induced analgesia. Conversely, the 
      serotonin antagonist methysergide significantly reversed the analgesic effects of 
      MDMA on the hot-plate test. These findings suggest that the antinociceptive 
      effects of MDMA are serotonergically mediated. Furthermore, the results verify 
      earlier findings describing the test-specific effects of serotonin-induced pain 
      modulation.
FAU - Crisp, T
AU  - Crisp T
AD  - Department of Pharmacology, Northeastern Ohio Universities, College of Medicine, 
      Rootstown 44272.
FAU - Stafinsky, J L
AU  - Stafinsky JL
FAU - Boja, J W
AU  - Boja JW
FAU - Schechter, M D
AU  - Schechter MD
LA  - eng
GR  - 480-1/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Amphetamines)
RN  - 0 (Analgesics)
RN  - 0 (Receptors, Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 5S6W795CQM (Naltrexone)
RN  - 76I7G6D29C (Morphine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - XZA9HY6Z98 (Methysergide)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
MH  - Amphetamines/*pharmacology
MH  - Analgesics/*pharmacology
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Male
MH  - Methysergide/pharmacology
MH  - Morphine/pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Naltrexone/pharmacology
MH  - Pain/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Serotonin/drug effects/*physiology
EDAT- 1989/11/01 00:00
MHDA- 1989/11/01 00:01
CRDT- 1989/11/01 00:00
PHST- 1989/11/01 00:00 [pubmed]
PHST- 1989/11/01 00:01 [medline]
PHST- 1989/11/01 00:00 [entrez]
AID - 0091-3057(89)90547-9 [pii]
AID - 10.1016/0091-3057(89)90547-9 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1989 Nov;34(3):497-501. doi: 
      10.1016/0091-3057(89)90547-9.