PMID- 25761697
OWN - NLM
STAT- MEDLINE
DCOM- 20150730
LR  - 20200930
IS  - 1522-1490 (Electronic)
IS  - 0363-6119 (Print)
IS  - 0363-6119 (Linking)
VI  - 308
IP  - 10
DP  - 2015 May 15
TI  - Chronic hyperleptinemia results in the development of hypertension in pregnant 
      rats.
PG  - R855-61
LID - 10.1152/ajpregu.00286.2014 [doi]
AB  - Despite the fact that obesity is a major risk factor for preeclampsia (PE), the 
      pathophysiological mechanisms whereby obesity and metabolic factors such as 
      leptin increase this risk are unclear. While human data have shown that 
      hyperleptinemia is associated with PE, the long-term effect of hyperleptinemia on 
      blood pressure during pregnancy is unknown. Thus we tested the hypothesis whether 
      chronic circulating leptin elevations in pregnant rats increase blood pressure 
      and placental factors known to play a role in PE. On gestational day (GD)14, rats 
      were assigned to the normal pregnant group with food intake ad libitum (control), 
      leptin-treated (0.5 mug.kg(-1).min(-1) ip) pregnant group with food intake ad 
      libitum (pregnant+LEP), and normal pregnant group with food intake adjusted to 
      the food intake of pregnant+LEP rats (pregnant-FR). On GD19, mean arterial 
      pressure (MAP) was assessed and tissues were collected. Serum leptin 
      concentration was elevated in pregnant+LEP compared with control and pregnant-FR 
      (18.0 +/- 2.8 vs. 0.8 +/- 0.1 vs. 0.3 +/- 0.1 ng/ml; P < 0.05), which was associated 
      with increased MAP (121.3 +/- 8.1 vs. 102.4 +/- 2.4 vs. 101.3 +/- 1.8 mmHg; P < 0.05). 
      Food intake and body weight were reduced in pregnant+LEP and pregnant-FR by the 
      end of gestation. Additionally, placentas and fetuses of these groups were 
      lighter than those of control. However, placental expression of tumor necrosis 
      factor-alpha was significantly greater in pregnant+LEP compared with controls (1.6 +/- 
      0.1 vs. 1.1 +/- 0.1 pg/mg; P < 0.05). In conclusion, leptin increases blood 
      pressure and placental tumor necrosis factor-alpha during pregnancy despite its 
      effect of reducing food intake and body weight, and represents a mechanism 
      whereby obesity can promote the development of hypertension in PE.
CI  - Copyright (c) 2015 the American Physiological Society.
FAU - Palei, Ana C
AU  - Palei AC
AD  - Department of Physiology and Biophysics and Cardiovascular Renal Research Center, 
      University of Mississippi Medical Center, Jackson, Mississippi.
FAU - Spradley, Frank T
AU  - Spradley FT
AD  - Department of Physiology and Biophysics and Cardiovascular Renal Research Center, 
      University of Mississippi Medical Center, Jackson, Mississippi.
FAU - Granger, Joey P
AU  - Granger JP
AD  - Department of Physiology and Biophysics and Cardiovascular Renal Research Center, 
      University of Mississippi Medical Center, Jackson, Mississippi jgranger@umc.edu.
LA  - eng
GR  - P01 HL051971/HL/NHLBI NIH HHS/United States
GR  - T32 HL105324/HL/NHLBI NIH HHS/United States
GR  - 1T32HL105324/HL/NHLBI NIH HHS/United States
GR  - P01HL051971/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20150311
PL  - United States
TA  - Am J Physiol Regul Integr Comp Physiol
JT  - American journal of physiology. Regulatory, integrative and comparative 
      physiology
JID - 100901230
RN  - 0 (Leptin)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Blood Pressure/drug effects/*physiology
MH  - Body Weight/drug effects/*physiology
MH  - Eating/drug effects/physiology
MH  - Female
MH  - Hypertension/*blood/pathology
MH  - Leptin/*blood/pharmacology
MH  - Organ Size/drug effects
MH  - Placenta/drug effects/pathology
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tumor Necrosis Factor-alpha/blood
PMC - PMC4436978
OTO - NOTNLM
OT  - blood pressure
OT  - hyperleptinemia
OT  - hypertension
OT  - preeclampsia
OT  - pregnancy
EDAT- 2015/03/13 06:00
MHDA- 2015/08/01 06:00
PMCR- 2016/05/15
CRDT- 2015/03/13 06:00
PHST- 2014/07/03 00:00 [received]
PHST- 2015/03/06 00:00 [accepted]
PHST- 2015/03/13 06:00 [entrez]
PHST- 2015/03/13 06:00 [pubmed]
PHST- 2015/08/01 06:00 [medline]
PHST- 2016/05/15 00:00 [pmc-release]
AID - ajpregu.00286.2014 [pii]
AID - R-00286-2014 [pii]
AID - 10.1152/ajpregu.00286.2014 [doi]
PST - ppublish
SO  - Am J Physiol Regul Integr Comp Physiol. 2015 May 15;308(10):R855-61. doi: 
      10.1152/ajpregu.00286.2014. Epub 2015 Mar 11.