PMID- 25762355
OWN - NLM
STAT- MEDLINE
DCOM- 20150723
LR  - 20181202
IS  - 1460-2385 (Electronic)
IS  - 0931-0509 (Print)
IS  - 0931-0509 (Linking)
VI  - 30
IP  - 5
DP  - 2015 May
TI  - Baseline hydration status in incident peritoneal dialysis patients: the 
      initiative of patient outcomes in dialysis (IPOD-PD study)dagger.
PG  - 849-58
LID - 10.1093/ndt/gfv013 [doi]
AB  - BACKGROUND: Non-euvolaemia in peritoneal dialysis (PD) patients is associated 
      with elevated mortality risk. There is an urgent need to collect data to help us 
      understand the association between clinical practices and hydration and 
      nutritional status, and their effects on patient outcome. METHODS: The aim of 
      this prospective international, longitudinal observational cohort study is to 
      follow up the hydration and nutritional status, as measured by bioimpedance 
      spectroscopy using the body composition monitor (BCM) of incident PD patients for 
      up to 5 years. Measures of hydration and nutritional status and of clinical, 
      biochemical and therapy-related data are collected directly before start of PD 
      treatment, at 1 and 3 months, and then every 3 months. This paper presents the 
      protocol and a pre-specified analysis of baseline data of the cohort. RESULTS: A 
      total of 1092 patients (58.1% male, 58.0 +/- 15.3 years) from 135 centres in 32 
      countries were included. Median fluid overload (FO) was 2.0 L (males) and 0.9 L 
      (females). Less than half of the patients were normohydrated (38.7%), whereas FO 
      > 1.1 L was seen in 56.5%. Systolic and diastolic blood pressure were 139.5 +/- 
      21.8 and 80.0 +/- 12.8 mmHg, respectively, and 25.1% of patients had congestive 
      heart failure [New York Heart Association (NYHA) 1 or higher]. A substantial 
      number of patients judged to be not overhydrated on clinical judgement appeared 
      to be overhydrated by BCM measurement. Overhydration at baseline was 
      independently associated with male gender and diabetic status. CONCLUSIONS: The 
      majority of patients starting on PD are overhydrated already at start of PD. This 
      may have important consequences on clinical outcomes and preservation of residual 
      renal function. Substantial reclassification of hydration status by BCM versus on 
      a clinical basis was necessary, especially in patients who were not overtly 
      overhydrated. Both clinical appreciation and bioimpedance should be combined in 
      clinical decision-making on hydration status.
CI  - (c) The Author 2015. Published by Oxford University Press on behalf of ERA-EDTA.
FAU - Ronco, Claudio
AU  - Ronco C
AD  - Department of Nephrology, Ospedale S. Bortolo, Vicenza, Italy.
FAU - Verger, Christian
AU  - Verger C
AD  - Centre Hospitalier Rene Dubos, Pontoise, France.
FAU - Crepaldi, Carlo
AU  - Crepaldi C
AD  - Department of Nephrology, Ospedale S. Bortolo, Vicenza, Italy.
FAU - Pham, Jenny
AU  - Pham J
AD  - Clinical Research, Fresenius Medical Care Deutschland GmbH, Bad Homburg, Germany.
FAU - De Los Rios, Tatiana
AU  - De Los Rios T
AD  - Clinical Research, Fresenius Medical Care Deutschland GmbH, Bad Homburg, Germany.
FAU - Gauly, Adelheid
AU  - Gauly A
AD  - Clinical Research, Fresenius Medical Care Deutschland GmbH, Bad Homburg, Germany.
FAU - Wabel, Peter
AU  - Wabel P
AD  - Clinical Research, Fresenius Medical Care Deutschland GmbH, Bad Homburg, Germany.
FAU - Van Biesen, Wim
AU  - Van Biesen W
AD  - Renal Division, Ghent University Hospital, Ghent, Belgium.
CN  - IPOD-PD Study Group
LA  - eng
SI  - ClinicalTrials.gov/NCT01285726
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20150311
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European 
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Pressure
MH  - *Body Composition
MH  - Diabetes Complications
MH  - Electric Impedance
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/complications
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Physiologic/*methods
MH  - Nutritional Status
MH  - *Peritoneal Dialysis
MH  - Prospective Studies
MH  - Sex Factors
MH  - Treatment Outcome
MH  - *Water-Electrolyte Imbalance
PMC - PMC4425480
OTO - NOTNLM
OT  - bioimpedance
OT  - end-stage renal disease
OT  - hydration status
OT  - peritoneal dialysis
OT  - prospective cohort study
OT  - volaemia
EDAT- 2015/03/13 06:00
MHDA- 2015/07/24 06:00
PMCR- 2015/03/11
CRDT- 2015/03/13 06:00
PHST- 2014/09/19 00:00 [received]
PHST- 2015/01/07 00:00 [accepted]
PHST- 2015/03/13 06:00 [entrez]
PHST- 2015/03/13 06:00 [pubmed]
PHST- 2015/07/24 06:00 [medline]
PHST- 2015/03/11 00:00 [pmc-release]
AID - gfv013 [pii]
AID - 10.1093/ndt/gfv013 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2015 May;30(5):849-58. doi: 10.1093/ndt/gfv013. Epub 
      2015 Mar 11.