PMID- 25762541
OWN - NLM
STAT- MEDLINE
DCOM- 20151214
LR  - 20231111
IS  - 1521-009X (Electronic)
IS  - 0090-9556 (Print)
IS  - 0090-9556 (Linking)
VI  - 43
IP  - 5
DP  - 2015 May
TI  - The 2014 Bernard B. Brodie award lecture-epoxide hydrolases: drug metabolism to 
      therapeutics for chronic pain.
PG  - 788-802
LID - 10.1124/dmd.115.063339 [doi]
AB  - Dr. Bernard Brodie's legacy is built on fundamental discoveries in pharmacology 
      and drug metabolism that were then translated to the clinic to improve patient 
      care. Similarly, the development of a novel class of therapeutics termed the 
      soluble epoxide hydrolase (sEH) inhibitors was originally spurred by fundamental 
      research exploring the biochemistry and physiology of the sEH. Here, we present 
      an overview of the history and current state of research on epoxide hydrolases, 
      specifically focusing on sEHs. In doing so, we start with the translational 
      project studying the metabolism of the insect juvenile hormone mimic R-20458 
      [(E)-6,7-epoxy-1-(4-ethylphenoxy)-3,7-dimethyl-2-octene], which led to the 
      identification of the mammalian sEH. Further investigation of this enzyme and its 
      substrates, including the epoxyeicosatrienoic acids, led to insight into 
      mechanisms of inflammation, chronic and neuropathic pain, angiogenesis, and other 
      physiologic processes. This basic knowledge in turn led to the development of 
      potent inhibitors of the sEH that are promising therapeutics for pain, 
      hypertension, chronic obstructive pulmonary disorder, arthritis, and other 
      disorders.
CI  - Copyright (c) 2015 by The American Society for Pharmacology and Experimental 
      Therapeutics.
FAU - Kodani, Sean D
AU  - Kodani SD
AD  - Department of Entomology and Nematology, Comprehensive Cancer Center, University 
      of California, Davis, California.
FAU - Hammock, Bruce D
AU  - Hammock BD
AD  - Department of Entomology and Nematology, Comprehensive Cancer Center, University 
      of California, Davis, California bdhammock@ucdavis.edu.
LA  - eng
GR  - P42-ES004699/ES/NIEHS NIH HHS/United States
GR  - R01 ES002710/ES/NIEHS NIH HHS/United States
GR  - R21-AR062866/AR/NIAMS NIH HHS/United States
GR  - P42 ES004699/ES/NIEHS NIH HHS/United States
GR  - R01-ES002170/ES/NIEHS NIH HHS/United States
GR  - R21 AR062866/AR/NIAMS NIH HHS/United States
GR  - T32 GM099608/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150311
PL  - United States
TA  - Drug Metab Dispos
JT  - Drug metabolism and disposition: the biological fate of chemicals
JID - 9421550
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Insect Hormones)
RN  - 0 (Juvenile Hormones)
RN  - 0 (Terpenes)
RN  - 37571-83-8 (ethylphenylepoxygeranyl ether)
RN  - EC 3.3.2.- (Epoxide Hydrolases)
SB  - IM
MH  - Animals
MH  - Awards and Prizes
MH  - Chronic Pain/*drug therapy/metabolism
MH  - Enzyme Inhibitors/pharmacology
MH  - Epoxide Hydrolases/*antagonists & inhibitors/*metabolism
MH  - Humans
MH  - Inactivation, Metabolic/*physiology
MH  - Inflammation/drug therapy/metabolism
MH  - Insect Hormones/metabolism
MH  - Insecta/metabolism
MH  - Juvenile Hormones/pharmacology
MH  - Terpenes/pharmacology
PMC - PMC4407705
EDAT- 2015/03/13 06:00
MHDA- 2015/12/15 06:00
PMCR- 2016/05/01
CRDT- 2015/03/13 06:00
PHST- 2015/01/15 00:00 [received]
PHST- 2015/03/11 00:00 [accepted]
PHST- 2015/03/13 06:00 [entrez]
PHST- 2015/03/13 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - dmd.115.063339 [pii]
AID - DMD_063339 [pii]
AID - 10.1124/dmd.115.063339 [doi]
PST - ppublish
SO  - Drug Metab Dispos. 2015 May;43(5):788-802. doi: 10.1124/dmd.115.063339. Epub 2015 
      Mar 11.