PMID- 25762915
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150312
LR  - 20201001
IS  - 1662-5161 (Print)
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 9
DP  - 2015
TI  - Love-related changes in the brain: a resting-state functional magnetic resonance 
      imaging study.
PG  - 71
LID - 10.3389/fnhum.2015.00071 [doi]
LID - 71
AB  - Romantic love is a motivational state associated with a desire to enter or 
      maintain a close relationship with a specific other person. Functional magnetic 
      resonance imaging (fMRI) studies have found activation increases in brain regions 
      involved in the processing of reward, motivation and emotion regulation, when 
      romantic lovers view photographs of their partners. However, not much is known 
      about whether romantic love affects the brain's functional architecture during 
      rest. In the present study, resting state functional magnetic resonance imaging 
      (rsfMRI) data was collected to compare the regional homogeneity (ReHo) and 
      functional connectivity (FC) across an "in-love" group (LG, N = 34, currently 
      intensely in love), an "ended-love" group (ELG, N = 34, ended romantic 
      relationship recently), and a "single" group (SG, N = 32, never fallen in love). 
      Results show that: (1) ReHo of the left dorsal anterior cingulate cortex (dACC) 
      was significantly increased in the LG (in comparison to the ELG and the SG); (2) 
      ReHo of the left dACC was positively correlated with length of time in love in 
      the LG, and negatively correlated with the lovelorn duration since breakup in the 
      ELG; (3) FC within the reward, motivation, and emotion regulation network (dACC, 
      insula, caudate, amygdala, and nucleus accumbens) as well as FC in the social 
      cognition network [temporo-parietal junction (TPJ), posterior cingulate cortex 
      (PCC), medial prefrontal cortex (MPFC), inferior parietal, precuneus, and 
      temporal lobe] was significantly increased in the LG (in comparison to the ELG 
      and SG); (4) in most regions within both networks FC was positively correlated 
      with the duration of love in the LG but negatively correlated with the lovelorn 
      duration of time since breakup in the ELG. This study provides first empirical 
      evidence of love-related alterations in brain functional architecture. 
      Furthermore, the results shed light on the underlying neural mechanisms of 
      romantic love, and demonstrate the possibility of applying a resting-state fMRI 
      approach for investigating romantic love.
FAU - Song, Hongwen
AU  - Song H
AD  - Faculty of Psychology, Southwest University, Chongqing China.
FAU - Zou, Zhiling
AU  - Zou Z
AD  - Faculty of Psychology, Southwest University, Chongqing China.
FAU - Kou, Juan
AU  - Kou J
AD  - Faculty of Psychology, Southwest University, Chongqing China.
FAU - Liu, Yang
AU  - Liu Y
AD  - Faculty of Psychology, Southwest University, Chongqing China.
FAU - Yang, Lizhuang
AU  - Yang L
AD  - CAS Key Laboratory of Brain Function & Disease, School of Life Sciences, 
      University of Science and Technology of China, Anhui China.
FAU - Zilverstand, Anna
AU  - Zilverstand A
AD  - Icahn School of Medicine at Mount Sinai, New York, NY USA.
FAU - d'Oleire Uquillas, Federico
AU  - d'Oleire Uquillas F
AD  - Icahn School of Medicine at Mount Sinai, New York, NY USA.
FAU - Zhang, Xiaochu
AU  - Zhang X
AD  - CAS Key Laboratory of Brain Function & Disease, School of Life Sciences, 
      University of Science and Technology of China, Anhui China ; CAS Center of 
      Medical Physics and Technology, University of Science and Technology of China, 
      Anhui China ; School of Humanities and Social Science, University of Science and 
      Technology of China, Anhui China.
LA  - eng
PT  - Journal Article
DEP - 20150213
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC4327739
OTO - NOTNLM
OT  - dorsal anterior cingulate cortex (dACC)
OT  - functional connectivity (FC)
OT  - nucleus accumbens
OT  - posterior cingulate cortex (PCC)
OT  - regional homogeneity (ReHo)
OT  - resting state fMRI (rsfMRI)
OT  - romantic love
OT  - temporo-parietal junction (TPJ)
EDAT- 2015/03/13 06:00
MHDA- 2015/03/13 06:01
PMCR- 2015/01/01
CRDT- 2015/03/13 06:00
PHST- 2014/09/25 00:00 [received]
PHST- 2015/01/28 00:00 [accepted]
PHST- 2015/03/13 06:00 [entrez]
PHST- 2015/03/13 06:00 [pubmed]
PHST- 2015/03/13 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fnhum.2015.00071 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2015 Feb 13;9:71. doi: 10.3389/fnhum.2015.00071. eCollection 
      2015.