PMID- 2576301
OWN - NLM
STAT- MEDLINE
DCOM- 19900412
LR  - 20151119
IS  - 0161-813X (Print)
IS  - 0161-813X (Linking)
VI  - 10
IP  - 3
DP  - 1989 Fall
TI  - Effects of gestational exposure to phencyclidine: distribution and neurochemical 
      alterations in maternal and fetal brain.
PG  - 383-92
AB  - Phencyclidine is a widely used drug of abuse and is known to produce a wide 
      variety of psychoactive effects. PCP abuse by pregnant women has been reported to 
      result in the birth of infants exhibiting irritability, jitteriness and 
      hyperactivity with high pitched cries. The present study was designed to evaluate 
      the distribution of PCP in the maternal and fetal brain and the neurochemical 
      effects produced by gestational exposure. Pregnant Sprague-Dawley rats were 
      treated sc with 5 mg/kg PCP on 3 consecutive days (GD 9-11, 12-14, 15-16, or 
      18-20). On gestational day (GD) 21 all rats were killed by decapitation and 
      maternal and fetal blood was collected for PCP analysis. Brains were dissected 
      from dams and fetuses for PCP and neurochemical analyses. On GD 21 after exposure 
      on GD 18-20, the fetal: maternal ratio of brain PCP concentrations was 11:1. PCP 
      exposure on GD 12-14, 15-17, and 18-20 significantly decreased fetal brain PCP 
      binding sites on GD 21, whereas maternal values were unchanged. Fetal 
      dopaminergic and muscarinic cholinergic receptor binding and neurotransmitter 
      concentrations were unaffected by prenatal PCP exposure. These data demonstrated 
      that maternal PCP exposure resulted in prolonged exposure of the developing CNS 
      and also indicated that gestational exposure to PCP decreased high affinity 
      binding sites of PCP in term fetal brain.
FAU - Ali, S F
AU  - Ali SF
AD  - Division of Reproductive and Developmental Toxicology, National Center for 
      Toxicological Research, Jefferson, Arkansas 72079.
FAU - Ahmad, G
AU  - Ahmad G
FAU - Slikker, W Jr
AU  - Slikker W Jr
FAU - Bondy, S C
AU  - Bondy SC
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Neurotoxicology
JT  - Neurotoxicology
JID - 7905589
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotransmitter Agents)
RN  - 0 (Receptors, Muscarinic)
RN  - 0 (Receptors, Neurotransmitter)
RN  - 0 (Receptors, Phencyclidine)
RN  - 4X6E73CJ0Q (Spiperone)
RN  - 6581-06-2 (Quinuclidinyl Benzilate)
RN  - J1DOI7UV76 (Phencyclidine)
SB  - IM
MH  - Animals
MH  - Brain/drug effects/*growth & development
MH  - Brain Chemistry/*drug effects
MH  - Female
MH  - Fetus/*physiology
MH  - Gestational Age
MH  - Nerve Tissue Proteins/metabolism
MH  - Neurotransmitter Agents/metabolism
MH  - Phencyclidine/metabolism/pharmacokinetics/*toxicity
MH  - Pregnancy
MH  - Pregnancy, Animal/*drug effects
MH  - Quinuclidinyl Benzilate
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Muscarinic/drug effects
MH  - Receptors, Neurotransmitter/metabolism
MH  - Receptors, Phencyclidine
MH  - Spiperone
EDAT- 1989/01/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
PST - ppublish
SO  - Neurotoxicology. 1989 Fall;10(3):383-92.