PMID- 25763268
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150312
LR  - 20201001
IS  - 2074-1804 (Print)
IS  - 2074-1812 (Electronic)
IS  - 2074-1804 (Linking)
VI  - 17
IP  - 1
DP  - 2015 Jan
TI  - Tumor necrosis factor-alpha polymorphism and susceptibility to multiple sclerosis 
      in the Iranian population.
PG  - e18247
LID - 10.5812/ircmj.18247 [doi]
LID - e18247
AB  - BACKGROUND: Multiple sclerosis (MS) is an immune-mediated disease of polygenic 
      etiology. Tumor necrosis factor-alpha (TNF-alpha) microsatellite as a proinflammatory 
      cytokine is believed to play an important role in the etiology of this disease. 
      OBJECTIVES: The aim of this study was to investigate the association of TNF-alpha 
      microsatellite sequence variation in patients with MS and its risk factor in the 
      southern Iranian population. PATIENTS AND METHODS: This polymorphism was 
      investigated in an Iranian population of 163 native southern people [81 patients 
      with MS according to the poser criteria and 82 healthy controls (HC) with the 
      same age, sex, social, ethnical and geographical features (Hormozgan and Fars 
      provinces)]. All the controls were nonimmunological, neurological patients. All 
      the cases and controls were chosen randomly and genotyped for polymorphism of 
      TNF-alpha microsatellite. RESULTS: The frequencies of TNF-alpha*11 (0.25, P < 0.005) and 
      TNF-alpha*10 (P < 0.005) alleles increased in patients with MS compared with 
      controls, showing a significant difference among the studied population. 
      CONCLUSIONS: The current study adds evidence to the association of TNF-alpha gene 
      polymorphism and MS in this southern south Iranian population which is consistent 
      with the genetic analysis of MS in Europeans (GAMES) project reports and these 
      two alleles reported in this study may be one of the genetic risk factor for MS. 
      Furthermore, this data can be used to build the Iranian gene bank for future 
      studies.
FAU - Rahmanian, Masoomeh
AU  - Rahmanian M
AD  - Young Researchers' Club, Department of Microbiology, Jahrom Branch, Islamic Azad 
      University, Jahrom, IR Iran.
FAU - Kargar, Mohammad
AU  - Kargar M
AD  - Department of Microbiology, Jahrom Branch, Islamic Azad University, Jahrom, IR 
      Iran.
LA  - eng
PT  - Journal Article
DEP - 20141227
PL  - Estonia
TA  - Iran Red Crescent Med J
JT  - Iranian Red Crescent medical journal
JID - 101319850
PMC - PMC4341370
OTO - NOTNLM
OT  - Multiple Sclerosis
OT  - Sclerosis
OT  - Tumor Necrosis Factor-Alpha
EDAT- 2015/03/13 06:00
MHDA- 2015/03/13 06:01
PMCR- 2015/01/01
CRDT- 2015/03/13 06:00
PHST- 2014/02/17 00:00 [received]
PHST- 2014/09/04 00:00 [revised]
PHST- 2014/11/01 00:00 [accepted]
PHST- 2015/03/13 06:00 [entrez]
PHST- 2015/03/13 06:00 [pubmed]
PHST- 2015/03/13 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.5812/ircmj.18247 [doi]
PST - epublish
SO  - Iran Red Crescent Med J. 2014 Dec 27;17(1):e18247. doi: 10.5812/ircmj.18247. 
      eCollection 2015 Jan.