PMID- 25763458
OWN - NLM
STAT- MEDLINE
DCOM- 20150803
LR  - 20220409
IS  - 1535-4970 (Electronic)
IS  - 1073-449X (Linking)
VI  - 191
IP  - 10
DP  - 2015 May 15
TI  - Risk Assessment of Tuberculosis in Contacts by IFN-gamma Release Assays. A 
      Tuberculosis Network European Trials Group Study.
PG  - 1176-84
LID - 10.1164/rccm.201502-0232OC [doi]
AB  - RATIONALE: Latent infection with Mycobacterium tuberculosis is defined by a 
      positive IFN-gamma release assay (IGRA) result in the absence of active tuberculosis. 
      Only few, mostly monocentric studies have evaluated the role of IGRAs to predict 
      the development of tuberculosis in recent contacts in low-incidence countries of 
      tuberculosis. OBJECTIVES: To analyze IGRA results and the effect of preventive 
      chemotherapy on tuberculosis progression rates among recent contacts. METHODS: 
      Results from contact investigations at 26 centers in 10 European countries 
      including testing for latent infection with M. tuberculosis by the QuantiFERON-TB 
      Gold In-Tube (QFT) test or the T-SPOT.TB (TSPOT) were prospectively collected and 
      analyzed. MEASUREMENTS AND MAIN RESULTS: Among 5,020 contacts of 1,023 index 
      cases, 25 prevalent secondary cases were identified at screening. Twenty-four 
      incident cases occurred among 4,513 contacts during 12,326 years of cumulative 
      follow-up. In those with a positive IGRA result, tuberculosis incidence was 0.2 
      (QFT) and 0 (TSPOT) per 100 patient-years when contacts received preventive 
      chemotherapy versus 1.2 (QFT) and 0.8 (TSPOT) per 100 patient-years in those not 
      treated (38 and 37 patients needed to be treated to prevent one case, 
      respectively). Positive and negative predictive values were 1.9% (95% confidence 
      interval [CI], 1.1-3.0) and 99.9% (95% CI, 99.7-100) for the QFT and 0.7% (95% 
      CI, 0.1-2.6) and 99.7% (95% CI, 99.1-99.9) for the TSPOT. CONCLUSIONS: 
      Tuberculosis rarely developed among contacts, and preventive chemotherapy 
      effectively reduced the tuberculosis risk among IGRA-positive contacts. Although 
      the negative predictive value of IGRAs is high, the risk for the development of 
      tuberculosis is poorly predicted by these assays.
FAU - Zellweger, Jean-Pierre
AU  - Zellweger JP
AD  - 1 Swiss Lung Association, Berne, Switzerland.
FAU - Sotgiu, Giovanni
AU  - Sotgiu G
FAU - Block, Michael
AU  - Block M
FAU - Dore, Simone
AU  - Dore S
FAU - Altet, Neus
AU  - Altet N
FAU - Blunschi, Rebecca
AU  - Blunschi R
FAU - Bogyi, Matthias
AU  - Bogyi M
FAU - Bothamley, Graham
AU  - Bothamley G
FAU - Bothe, Christina
AU  - Bothe C
FAU - Codecasa, Luigi
AU  - Codecasa L
FAU - Costa, Patrizia
AU  - Costa P
FAU - Dominguez, Jose
AU  - Dominguez J
FAU - Duarte, Raquel
AU  - Duarte R
FAU - Floe, Andreas
AU  - Floe A
FAU - Fresard, Isabelle
AU  - Fresard I
FAU - Garcia-Garcia, Jose-Maria
AU  - Garcia-Garcia JM
FAU - Goletti, Delia
AU  - Goletti D
FAU - Halm, Petra
AU  - Halm P
FAU - Hellwig, Doris
AU  - Hellwig D
FAU - Henninger, Eveline
AU  - Henninger E
FAU - Heykes-Uden, Helga
AU  - Heykes-Uden H
FAU - Horn, Liane
AU  - Horn L
FAU - Kruczak, Katarzyna
AU  - Kruczak K
FAU - Latorre, Irene
AU  - Latorre I
FAU - Pache, Genevieve
AU  - Pache G
FAU - Rath, Heidrun
AU  - Rath H
FAU - Ringshausen, Felix C
AU  - Ringshausen FC
FAU - Ruiz, Asuncion Seminario
AU  - Ruiz AS
FAU - Solovic, Ivan
AU  - Solovic I
FAU - Souza-Galvao, Maria-Luiza de
AU  - Souza-Galvao ML
FAU - Widmer, Ursula
AU  - Widmer U
FAU - Witte, Peter
AU  - Witte P
FAU - Lange, Christoph
AU  - Lange C
CN  - TBNET
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Antitubercular Agents)
SB  - IM
CIN - Am J Respir Crit Care Med. 2015 May 15;191(10):1101-3. PMID: 25978570
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antitubercular Agents/*administration & dosage
MH  - Chemoprevention
MH  - Child
MH  - Child, Preschool
MH  - *Contact Tracing
MH  - Disease Progression
MH  - Europe
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Interferon-gamma Release Tests
MH  - Latent Tuberculosis/diagnosis/*transmission
MH  - Male
MH  - Middle Aged
MH  - Multicenter Studies as Topic
MH  - Mycobacterium tuberculosis/immunology/isolation & purification
MH  - Risk Assessment/methods
MH  - Tuberculin Test/methods
MH  - Tuberculosis/diagnosis/drug therapy/prevention & control
MH  - Young Adult
OTO - NOTNLM
OT  - IFN-gamma release assay
OT  - LTBI
OT  - QuantiFERON
OT  - T-SPOT.TB
OT  - tuberculosis
FIR - Aeby, Myriam
IR  - Aeby M
FIR - Cuzzi, Gilda
IR  - Cuzzi G
FIR - Girardi, Enrio
IR  - Girardi E
FIR - Vanini, Valentina
IR  - Vanini V
FIR - Vecchi, Eleonora
IR  - Vecchi E
FIR - Lauria, Francesco Nicola
IR  - Lauria FN
FIR - Vecchi, Marco
IR  - Vecchi M
FIR - Ferrarese, Maurizio
IR  - Ferrarese M
FIR - Repossi, Alice
IR  - Repossi A
FIR - Gerdes, Silke
IR  - Gerdes S
FIR - Haller, Martina
IR  - Haller M
FIR - Glaewe, Andrea
IR  - Glaewe A
FIR - Krabbe, Lenka
IR  - Krabbe L
FIR - Hilberg, Ole
IR  - Hilberg O
FIR - Janssens, Jean-Paul
IR  - Janssens JP
FIR - Rubsamen, Christof
IR  - Rubsamen C
FIR - Schlosser, Stephan
IR  - Schlosser S
FIR - Villanueva-Montes, Manuel-Angel
IR  - Villanueva-Montes MA
EDAT- 2015/03/13 06:00
MHDA- 2015/08/04 06:00
CRDT- 2015/03/13 06:00
PHST- 2015/03/13 06:00 [entrez]
PHST- 2015/03/13 06:00 [pubmed]
PHST- 2015/08/04 06:00 [medline]
AID - 10.1164/rccm.201502-0232OC [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2015 May 15;191(10):1176-84. doi: 
      10.1164/rccm.201502-0232OC.