PMID- 25764350
OWN - NLM
STAT- MEDLINE
DCOM- 20160113
LR  - 20150428
IS  - 1098-2396 (Electronic)
IS  - 0887-4476 (Linking)
VI  - 69
IP  - 6
DP  - 2015 Jun
TI  - Dendritic morphology changes in neurons from the ventral hippocampus, amygdala 
      and nucleus accumbens in rats with neonatal lesions into the prefrontal cortex.
PG  - 314-25
LID - 10.1002/syn.21815 [doi]
AB  - Neonatal prefrontal cortex (nPFC) lesions in rats could be a potential animal 
      model to study the early neurodevelopmental abnormalities associated with the 
      behavioral and morphological brain changes observed in schizophrenia. 
      Morphological alterations in pyramidal neurons from the ventral hippocampus (VH) 
      have been observed in post-mortem schizophrenic brains, mainly because of 
      decreased dendritic arbor and spine density. We assessed the effects of 
      nPFC-lesions on the dendritic morphology of neurons from the VH, 
      basolateral-amygdala (BLA) and the nucleus accumbens (NAcc) in rats. nPFC lesions 
      were made on postnatal day 7 (PD7), after dendritic morphology was studied by the 
      Golgi-Cox stain procedure followed by Sholl analysis at PD35 (prepubertal) and 
      PD60 (adult) ages. We also evaluated the effects of PFC-lesions on locomotor 
      activity caused by a novel environment. Adult animals with nPFC lesions showed a 
      decreased spine density in pyramidal neurons from the VH and in medium spiny 
      cells from the NAcc. An increased locomotion was observed in a novel environment 
      for adult animals with a PFC-lesion. Our results indicate that PFC-lesions alter 
      the neuronal dendrite morphology of the NAcc and the VH, suggesting a 
      disconnection between these limbic structures. The locomotion paradigms suggest 
      that dopaminergic transmission is altered in the PFC lesion model. This could 
      help to understand the consequences of an earlier PFC dysfunction in 
      schizophrenia. To evaluate possible dendritic changes in neonatal prefrontal 
      cortex lesions in schizophrenia-related regions including nucleus accumbens, 
      ventral hippocampus and basolateral amygdala, we used the Golgi-Cox stain samples 
      at PD35 and PD70. Our results suggest that neonatal prefrontal cortex damage 
      alters dendritic parameters in limbic regions, and this has potential 
      implications for schizophrenia.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Lazcano, Zayda
AU  - Lazcano Z
AD  - Laboratorio de Neuropsiquiatria, Instituto de Fisiologia, Universidad Autonoma de 
      Puebla, Puebla, Mexico.
FAU - Solis, Oscar
AU  - Solis O
FAU - Diaz, Alfonso
AU  - Diaz A
FAU - Brambila, Eduardo
AU  - Brambila E
FAU - Aguilar-Alonso, Patricia
AU  - Aguilar-Alonso P
FAU - Guevara, Jorge
AU  - Guevara J
FAU - Flores, Gonzalo
AU  - Flores G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
SB  - IM
MH  - Amygdala/*pathology/physiopathology
MH  - Animals
MH  - Animals, Newborn
MH  - Dendrites/*pathology/physiology
MH  - Hippocampus/*pathology/physiopathology
MH  - Locomotion/physiology
MH  - Models, Animal
MH  - Neurons/pathology/physiology
MH  - Nucleus Accumbens/*pathology/physiopathology
MH  - Prefrontal Cortex/*growth & development/*pathology/physiopathology
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - basolateral amygdale
OT  - dendritic morphology
OT  - locomotor activity
OT  - neonatal prefrontal cortex lesion
OT  - neurodevelopment
OT  - nucleus accumbens
OT  - schizophrenia
EDAT- 2015/03/13 06:00
MHDA- 2016/01/14 06:00
CRDT- 2015/03/13 06:00
PHST- 2014/09/29 00:00 [received]
PHST- 2015/03/09 00:00 [revised]
PHST- 2015/03/09 00:00 [accepted]
PHST- 2015/03/13 06:00 [entrez]
PHST- 2015/03/13 06:00 [pubmed]
PHST- 2016/01/14 06:00 [medline]
AID - 10.1002/syn.21815 [doi]
PST - ppublish
SO  - Synapse. 2015 Jun;69(6):314-25. doi: 10.1002/syn.21815.