PMID- 25764636
OWN - NLM
STAT- MEDLINE
DCOM- 20150512
LR  - 20181202
IS  - 0125-2208 (Print)
IS  - 0125-2208 (Linking)
VI  - 97
IP  - 12
DP  - 2014 Dec
TI  - Relationship between emphysema quantification and COPD severity.
PG  - 1290-5
AB  - OBJECTIVE: To determine the association between emphysema extent from 
      high-resolution computed tomography (HRCT) and the physiological derangement in 
      patients with chronic obstructive pulmonary disease (COPD). MATERIAL AND METHOD: 
      A cross-sectional study was undertaken to quantify the emphysema severity in 23 
      COPD patients by automated HRCT scoring techniques. Correlation with phenotypic 
      characters in term of exercise capacity [Modified Medical Research Council (mMRC) 
      dyspnea scale, and 6-minute walk distance (6MWD)], pulmonary function testing 
      [spirometry (forced expiratory volume in 1 second, FEV1 and forced vital 
      capacity, FVC), and diffusing capacity (DLCO)], were then assessed. RESULTS: 
      Nineteen patients were male and four were female, the mean age was 73 +/- 8 years, 
      with the mean FEV1 % predicted of 67.8 +/- 25.4. Percentage of inspiratory 
      emphysematous lung volume (%ELVi) had significant negative correlation with 
      %FEV/FVC (r = -0.50, p = 0.016) and DLCO (r = 0.58, p = 0.011). Percentage of 
      expiratory emphysematous lung volumes (%ELVe) also had the same correlation with 
      %FEV/FVC (r = -0.58, p = 0.004) and DLCO (r = 0.48, p = 0.042). In addition, 
      %ELVe also had significant negative correlation with 6MWD (r = 0.50, p = 0.016), 
      but had significant positive correlation with mMRC scale (r = 0.53, p = 0.01). 
      CONCLUSION: Severity of emphysema assessed by HRCT was well correlated with 
      pulmonary function test results and exercise capacity. It can be used as one 
      aspect ofphenotypic characters in patients with COPD,for designing personalize 
      management plan.
FAU - Chierakul, Nitipatana
AU  - Chierakul N
FAU - Phanphongsiri, Saowaluk
AU  - Phanphongsiri S
FAU - Chuaychoo, Benjamas
AU  - Chuaychoo B
FAU - Muangman, Nisa
AU  - Muangman N
FAU - Totanarungroj, Kanyarat
AU  - Totanarungroj K
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - J Med Assoc Thai
JT  - Journal of the Medical Association of Thailand = Chotmaihet thangphaet
JID - 7507216
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Pulmonary Disease, Chronic Obstructive/*diagnostic imaging/*physiopathology
MH  - Pulmonary Emphysema/*diagnostic imaging/*physiopathology
MH  - Respiratory Function Tests
MH  - Severity of Illness Index
MH  - Tomography, X-Ray Computed
EDAT- 2015/03/15 06:00
MHDA- 2015/05/13 06:00
CRDT- 2015/03/14 06:00
PHST- 2015/03/14 06:00 [entrez]
PHST- 2015/03/15 06:00 [pubmed]
PHST- 2015/05/13 06:00 [medline]
PST - ppublish
SO  - J Med Assoc Thai. 2014 Dec;97(12):1290-5.