PMID- 25764907
OWN - NLM
STAT- MEDLINE
DCOM- 20151026
LR  - 20221207
IS  - 1532-8384 (Electronic)
IS  - 0010-440X (Linking)
VI  - 59
DP  - 2015 May
TI  - The analysis of BDNF gene polymorphism haplotypes and impulsivity in 
      methamphetamine abusers.
PG  - 62-7
LID - S0010-440X(15)00033-4 [pii]
LID - 10.1016/j.comppsych.2015.02.017 [doi]
AB  - An increasing number of evidence showed that genetic factors might contribute to 
      drug abuse vulnerability. Data from genetic scans in humans suggest that 
      brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor 
      family, may be associated with substance abuse or dependence. To test the 
      hypothesis that the BDNF gene polymorphism is involved in methamphetamine abuse, 
      we compared three single nucleotide polymorphisms (SNPs, rs16917204, rs16917234, 
      and rs2030324) of the BDNF gene in 200 methamphetamine abusers and 219 healthy 
      individuals. We also considered the association of these polymorphisms with 
      impulsivity in methamphetamine abusers using Barratt Impulsivity Scale-11(BIS-11) 
      Chinese version. Individual SNP analysis showed no significant differences in 
      genotype and allele distributions between the methamphetamine abusers and 
      controls. Haplotype analysis of rs16917204-rs16917234-rs2030324 revealed that a 
      major C-C-T haplotype was significantly associated a lower odds of 
      methamphetamine abuse, even after Bonferroni correction. Within the 
      methamphetamine-abuse group, subjects carrying the T allele of rs2030324 genotype 
      had significantly higher motor impulsivity scores of BIS compared to those with 
      the C/C genotype. Our findings suggest that the BDNF gene polymorphism may 
      contribute to the impulsivity in methamphetamine abusers.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Su, Hang
AU  - Su H
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai, SH200025, PR China.
FAU - Tao, Jingyan
AU  - Tao J
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, China.
FAU - Zhang, Jie
AU  - Zhang J
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, China.
FAU - Xie, Ying
AU  - Xie Y
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, China.
FAU - Han, Bin
AU  - Han B
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, China.
FAU - Lu, Yuling
AU  - Lu Y
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, China.
FAU - Sun, Haiwei
AU  - Sun H
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, China.
FAU - Wei, Youdan
AU  - Wei Y
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, China.
FAU - Wang, Yue
AU  - Wang Y
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, China.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, China.
FAU - Zou, Shengzhen
AU  - Zou S
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, China.
FAU - Wu, Wenxiu
AU  - Wu W
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, China.
FAU - Zhang, Jiajia
AU  - Zhang J
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, China.
FAU - Xu, Ke
AU  - Xu K
AD  - Department of Psychiatry, Yale University, 300 George Street, Suite 901, New 
      Haven, CT, 06511, USA.
FAU - Zhang, Xiangyang
AU  - Zhang X
AD  - Beijing HuiLongGuan Hospital, Peking University, Beijing, BJ, 100096, PR China; 
      Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of 
      Medicine, Houston, TX, 77030, USA. Electronic address: xyzhang@bcm.edu.
FAU - He, Jincai
AU  - He J
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, China. Electronic address: hjc@wmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150303
PL  - United States
TA  - Compr Psychiatry
JT  - Comprehensive psychiatry
JID - 0372612
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Alleles
MH  - Amphetamine-Related Disorders/*genetics/*psychology
MH  - Asian People/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Haplotypes/*genetics
MH  - Humans
MH  - *Impulsive Behavior
MH  - Polymorphism, Single Nucleotide/*genetics
EDAT- 2015/03/15 06:00
MHDA- 2015/10/27 06:00
CRDT- 2015/03/14 06:00
PHST- 2014/11/24 00:00 [received]
PHST- 2015/02/17 00:00 [revised]
PHST- 2015/02/25 00:00 [accepted]
PHST- 2015/03/14 06:00 [entrez]
PHST- 2015/03/15 06:00 [pubmed]
PHST- 2015/10/27 06:00 [medline]
AID - S0010-440X(15)00033-4 [pii]
AID - 10.1016/j.comppsych.2015.02.017 [doi]
PST - ppublish
SO  - Compr Psychiatry. 2015 May;59:62-7. doi: 10.1016/j.comppsych.2015.02.017. Epub 
      2015 Mar 3.