PMID- 25766717
OWN - NLM
STAT- MEDLINE
DCOM- 20160404
LR  - 20181113
IS  - 1550-9397 (Electronic)
IS  - 1550-9389 (Print)
IS  - 1550-9389 (Linking)
VI  - 11
IP  - 6
DP  - 2015 Jun 15
TI  - Improved Sleep Quality is Associated with Reductions in Depression and PTSD 
      Arousal Symptoms and Increases in IGF-1 Concentrations.
PG  - 615-23
LID - 10.5664/jcsm.4770 [doi]
AB  - STUDY OBJECTIVES: One-third of deployed military personnel will be diagnosed with 
      insomnia, placing them at high risk for comorbid depression, posttraumatic stress 
      disorder (PTSD), and medical conditions. The disruption of trophic factors has 
      been implicated in these comorbid conditions, which can impede postdeployment 
      recovery. This study determined if improved sleep quality is associated with (1) 
      reductions in depression and posttraumatic symptoms, as well as enrichments in 
      health-related quality of life (HRQOL), and (2) changes in plasma concentrations 
      of brain derived neurotrophic factor (BDNF) and insulin-like growth factor-1 
      (IGF-1). METHODS: Forty-four military personnel diagnosed with insomnia underwent 
      clinical evaluations and blood draws at pretreatment and at posttreatment 
      following cognitive behavioral therapy for insomnia and automatic positive airway 
      pressure treatment. Participants were classified as sleep improved (n = 28) or 
      sleep declined (n = 16) based on their change in pretreatment to posttreatment 
      Pittsburgh Sleep Quality Index (PSQI) score. Both groups were compared on 
      outcomes of depression, PTSD, HRQOL, BDNF, and IGF-1. RESULTS: Paired t-tests of 
      the sleep improved group revealed significant declines in depression (p = 0.005) 
      and posttraumatic arousal (p = 0.006) symptoms, and a significant increase in 
      concentrations of IGF-1 (p = 0.009). The sleep declined group had no relevant 
      change in psychiatric symptoms or trophic factors, and had further declines on 
      five of eight dimensions of HRQOL. Between-group change score differences were 
      significant at p < 0.05. CONCLUSIONS: These findings suggest that interventions, 
      which successfully improve sleep quality, are an effective means to reduce the 
      depression and posttraumatic arousal symptoms common to military personnel, as 
      well as increase protective trophic factors implicated in these conditions.
CI  - (c) 2015 American Academy of Sleep Medicine.
FAU - Rusch, Heather L
AU  - Rusch HL
AD  - National Institute of Nursing Research, National Institutes of Health, Bethesda, 
      MD.
AD  - Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, 
      MD.
FAU - Guardado, Pedro
AU  - Guardado P
AD  - National Institute of Nursing Research, National Institutes of Health, Bethesda, 
      MD.
FAU - Baxter, Tristin
AU  - Baxter T
AD  - Madigan Army Medical Center, Tacoma, WA.
FAU - Mysliwiec, Vincent
AU  - Mysliwiec V
AD  - Madigan Army Medical Center, Tacoma, WA.
FAU - Gill, Jessica M
AU  - Gill JM
AD  - National Institute of Nursing Research, National Institutes of Health, Bethesda, 
      MD.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20150615
PL  - United States
TA  - J Clin Sleep Med
JT  - Journal of clinical sleep medicine : JCSM : official publication of the American 
      Academy of Sleep Medicine
JID - 101231977
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
CIN - J Clin Sleep Med. 2015 Oct;11(10):1243. PMID: 26414981
CIN - J Clin Sleep Med. 2015 Oct;11(10):1245-6. PMID: 26414987
MH  - Adolescent
MH  - Adult
MH  - Arousal/physiology
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Comorbidity
MH  - Depressive Disorder/blood/*epidemiology/psychology
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Military Personnel/psychology/statistics & numerical data
MH  - Sleep/physiology
MH  - Sleep Initiation and Maintenance Disorders/*blood/*epidemiology/psychology
MH  - Stress Disorders, Post-Traumatic/blood/*epidemiology/psychology
MH  - Surveys and Questionnaires
MH  - Young Adult
PMC - PMC4442222
OTO - NOTNLM
OT  - BDNF
OT  - IGF-1
OT  - PTSD
OT  - depression
OT  - insomnia
OT  - mTBI
OT  - military
OT  - sleep quality
OT  - trauma
EDAT- 2015/03/15 06:00
MHDA- 2016/04/05 06:00
PMCR- 2015/12/15
CRDT- 2015/03/14 06:00
PHST- 2014/10/24 00:00 [received]
PHST- 2015/01/09 00:00 [accepted]
PHST- 2015/03/14 06:00 [entrez]
PHST- 2015/03/15 06:00 [pubmed]
PHST- 2016/04/05 06:00 [medline]
PHST- 2015/12/15 00:00 [pmc-release]
AID - jc-00412-14 [pii]
AID - 10.5664/jcsm.4770 [doi]
PST - epublish
SO  - J Clin Sleep Med. 2015 Jun 15;11(6):615-23. doi: 10.5664/jcsm.4770.