PMID- 25768092
OWN - NLM
STAT- MEDLINE
DCOM- 20160822
LR  - 20190816
IS  - 1439-1651 (Electronic)
IS  - 0948-2393 (Linking)
VI  - 219
IP  - 5
DP  - 2015 Oct
TI  - [Combination of Excessive Weight Gain and Interleukin-8: A Possible Predictor of 
      Necrotising Enterocolitis in Neonates?].
PG  - 221-5
LID - 10.1055/s-0034-1395540 [doi]
AB  - BACKGROUND: Weight gain before the clinical diagnosis of necrotising 
      enterocolitis (NEC) is described as a predictive factor. HYPOTHESIS: Weight gain 
      of more than 5% one day prior to clinical suspicion plus increase of plasma 
      Iinterleukin-8 (IL-8) are predictive for NEC. METHODS: 48 infants with diagnosis 
      of NEC stage II and III were enrolled in a case-control study. Oral and 
      parenteral nutrition, diuresis and kinetics of weight and of IL-8 were 
      documented. RESULTS: 31 infants with NEC-II and 17 infants with NEC-III were 
      enrolled. Weight gain>5% occurred in 35.3% of NEC-III, in 0% of NEC-II and in 
      4.2% of the control group. IL-8 increased significantly [NEC-III (6 561.4 pg/mL) 
      vs. NEC-II: (326.7 pg/mL) vs. control group (38.9 pg/mL); p<0.05]. Sensitivity of 
      IL-8 in NEC-II was 87.10% (70.15-96.25) and in NEC-III 100.00% (80.33-100.00). 
      Sensitivity of weight gain was 0.00% (0.00-11.32) in NEC-II and 35.29% 
      (14.30-61.65) in NEC-III. CONCLUSION: Weight gain>5% was found in only 35.3% of 
      the cases with NEC-III. Combination of weight gain and IL-8 did not improve the 
      diagnosis of NEC.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Neunhoeffer, F
AU  - Neunhoeffer F
AD  - Universitatsklinik fur Kinder- und Jugendmedizin Tubingen Abteilung II: 
      Kardiologie, Intensivmedizin, Pulmologie.
FAU - Jansen, H
AU  - Jansen H
AD  - Universitatsklinik fur Kinder- und Jugendmedizin Tubingen Abteilung IV: 
      Neonatologie.
FAU - Goelz, R
AU  - Goelz R
AD  - Universitatsklinik fur Kinder- und Jugendmedizin Tubingen Abteilung IV: 
      Neonatologie.
FAU - Renk, H
AU  - Renk H
AD  - Universitatsklinik fur Kinder- und Jugendmedizin Tubingen Abteilung II: 
      Kardiologie, Intensivmedizin, Pulmologie.
FAU - Poets, C
AU  - Poets C
AD  - Universitatsklinik fur Kinder- und Jugendmedizin Tubingen Abteilung IV: 
      Neonatologie.
FAU - Seitz, G
AU  - Seitz G
AD  - Universitatsklinik fur Kinder- und Jugendmedizin Tubingen Abteilung V: 
      Kinderchirurgie, Kinderurologie.
FAU - Wacker, A
AU  - Wacker A
AD  - Universitatsklinik fur Kinder- und Jugendmedizin Tubingen Abteilung IV: 
      Neonatologie.
FAU - Orlikowsky, T
AU  - Orlikowsky T
AD  - Uniklinik RWTH Aachen Klinik fur Kinder- und Jugendmedizin Sektion Neonatologie.
LA  - ger
PT  - Journal Article
TT  - Kann ein Gewichtssprung in Kombination mit einem Anstieg des Interleukin-8 eine 
      nekrotisierende Enterokolitis bei Neonaten vorhersagen?
DEP - 20150313
PL  - Germany
TA  - Z Geburtshilfe Neonatol
JT  - Zeitschrift fur Geburtshilfe und Neonatologie
JID - 9508901
RN  - 0 (Biomarkers)
RN  - 0 (CXCL8 protein, human)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Biomarkers/blood
MH  - Enterocolitis, Necrotizing/blood/*diagnosis/*physiopathology
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Interleukin-8/*blood
MH  - Male
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - *Weight Gain
EDAT- 2015/03/15 06:00
MHDA- 2016/08/23 06:00
CRDT- 2015/03/14 06:00
PHST- 2015/03/14 06:00 [entrez]
PHST- 2015/03/15 06:00 [pubmed]
PHST- 2016/08/23 06:00 [medline]
AID - 10.1055/s-0034-1395540 [doi]
PST - ppublish
SO  - Z Geburtshilfe Neonatol. 2015 Oct;219(5):221-5. doi: 10.1055/s-0034-1395540. Epub 
      2015 Mar 13.