PMID- 25768813
OWN - NLM
STAT- MEDLINE
DCOM- 20151117
LR  - 20150315
IS  - 1525-8955 (Electronic)
IS  - 0885-3010 (Linking)
VI  - 62
IP  - 3
DP  - 2015 Mar
TI  - A versatile and experimentally validated finite element model to assess the 
      accuracy of shear wave elastography in a bounded viscoelastic medium.
PG  - 439-50
LID - 10.1109/TUFFC.2014.006682 [doi]
AB  - The feasibility of shear wave elastography (SWE) in arteries for cardiovascular 
      risk assessment remains to be investigated as the artery's thin wall and 
      intricate material properties induce complex shear wave (SW) propagation 
      phenomena. To better understand the SW physics in bounded media, we proposed an 
      in vitro validated finite element model capable of simulating SW propagation, 
      with full flexibility at the level of the tissue's geometry, material properties, 
      and acoustic radiation force. This computer model was presented in a relatively 
      basic set-up, a homogeneous slab of gelatin-agar material (4.35 mm thick), 
      allowing validation of the numerical settings according to actual SWE 
      measurements. The resulting tissue velocity waveforms and SW propagation speed 
      matched well with the measurement: 4.46 m/s (simulation) versus 4.63 +/- 0.07 m/s 
      (experiment). Further, we identified the impact of geometrical and material 
      parameters on the SW propagation characteristics. As expected, phantom thickness 
      was a determining factor of dispersion. Adding viscoelasticity to the model 
      augmented the estimated wave speed to 4.58 m/s, an even better match with the 
      experimental determined value. This study demonstrated that finite element 
      modeling can be a powerful tool to gain insight into SWE mechanics and will in 
      future work be advanced to more clinically relevant settings.
FAU - Caenen, Annette
AU  - Caenen A
FAU - Shcherbakova, Darya
AU  - Shcherbakova D
FAU - Verhegghe, Benedict
AU  - Verhegghe B
FAU - Papadacci, Clement
AU  - Papadacci C
FAU - Pernot, Mathieu
AU  - Pernot M
FAU - Segers, Patrick
AU  - Segers P
FAU - Swillens, Abigail
AU  - Swillens A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - IEEE Trans Ultrason Ferroelectr Freq Control
JT  - IEEE transactions on ultrasonics, ferroelectrics, and frequency control
JID - 9882735
SB  - IM
MH  - Algorithms
MH  - Computer Simulation
MH  - Elastic Modulus
MH  - Elasticity Imaging Techniques/instrumentation/*methods/*standards
MH  - *Finite Element Analysis
MH  - *Models, Biological
MH  - Phantoms, Imaging
MH  - Viscosity
EDAT- 2015/03/15 06:00
MHDA- 2015/11/18 06:00
CRDT- 2015/03/14 06:00
PHST- 2015/03/14 06:00 [entrez]
PHST- 2015/03/15 06:00 [pubmed]
PHST- 2015/11/18 06:00 [medline]
AID - 10.1109/TUFFC.2014.006682 [doi]
PST - ppublish
SO  - IEEE Trans Ultrason Ferroelectr Freq Control. 2015 Mar;62(3):439-50. doi: 
      10.1109/TUFFC.2014.006682.