PMID- 25769588
OWN - NLM
STAT- MEDLINE
DCOM- 20150917
LR  - 20181202
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 47
IP  - 2
DP  - 2015 Mar
TI  - Prevalence of hypertension after living-donor liver transplantation: a 
      prospective study.
PG  - 445-50
LID - S0041-1345(14)01241-X [pii]
LID - 10.1016/j.transproceed.2014.10.050 [doi]
AB  - BACKGROUND: Hypertension is common among patients who have undergone liver 
      transplantation and is a major contributor to cardiovascular events. Few studies 
      have studied the risk factors associated with post-liver transplantation (LT) 
      hypertension. This prospective study assessed the prevalence of post-LT 
      hypertension and associated preoperative risk factors. METHODS: From May 2008 to 
      December 2009, 79 normotensive adult patients (>/= 18 years old) who underwent 
      living-donor LT with a median follow up of 4.79 +/- 0.88 years were enrolled. 
      Patients' pre-LT demographics, clinical data, pre-LT diabetes, and 
      immunosuppressive agents used after LT were studied for their association with 
      post-LT hypertension. RESULTS: The prevalence of post-LT hypertension was 49.4%. 
      The independent risk factors for post-living-donor LT hypertension were pre-LT 
      systolic blood pressure (SBP; odds ratio [OR], 1.04; 95% confidence interval 
      [CI], 1.00-1.09; P = .039) and post-LT administration of mammalian target of 
      rapamycin (mTOR) inhibitors (OR, 4.08; 95% CI, 1.40-11.94; P = .010). Pre-LT 
      diabetes had a negative predictive value (OR, 0.15; 95% CI, 0.03-0.74; P = .019). 
      Neither age, male sex, smoking, pre-LT serum cholesterol and triglyceride levels, 
      tacrolimus, nor glucocorticoid was associated with post-LT hypertension. 
      CONCLUSIONS: The prevalence of hypertension is high after LT. Higher pre-LT SBP 
      and post-LT mTOR inhibitor administration predispose patients to post-LT 
      hypertension.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Tong, M-S
AU  - Tong MS
AD  - Section of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung 
      Memorial Hospital, Kaohsiung City, Taiwan, Republic of China; Chang Gung 
      University College of Medicine, Kaohsiung City, Taiwan, Republic of China.
FAU - Chai, H-T
AU  - Chai HT
AD  - Section of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung 
      Memorial Hospital, Kaohsiung City, Taiwan, Republic of China; Chang Gung 
      University College of Medicine, Kaohsiung City, Taiwan, Republic of China.
FAU - Liu, W-H
AU  - Liu WH
AD  - Section of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung 
      Memorial Hospital, Kaohsiung City, Taiwan, Republic of China; Chang Gung 
      University College of Medicine, Kaohsiung City, Taiwan, Republic of China.
FAU - Chen, C-L
AU  - Chen CL
AD  - Chang Gung University College of Medicine, Kaohsiung City, Taiwan, Republic of 
      China; Liver Transplantation Program, Department of Surgery, Kaohsiung Chang Gung 
      Memorial Hospital, Kaohsiung City, Taiwan, Republic of China.
FAU - Fu, M
AU  - Fu M
AD  - Section of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung 
      Memorial Hospital, Kaohsiung City, Taiwan, Republic of China; Chang Gung 
      University College of Medicine, Kaohsiung City, Taiwan, Republic of China.
FAU - Lin, Y-H
AU  - Lin YH
AD  - Chang Gung University College of Medicine, Kaohsiung City, Taiwan, Republic of 
      China; Liver Transplantation Program, Department of Surgery, Kaohsiung Chang Gung 
      Memorial Hospital, Kaohsiung City, Taiwan, Republic of China.
FAU - Lin, C-C
AU  - Lin CC
AD  - Chang Gung University College of Medicine, Kaohsiung City, Taiwan, Republic of 
      China; Liver Transplantation Program, Department of Surgery, Kaohsiung Chang Gung 
      Memorial Hospital, Kaohsiung City, Taiwan, Republic of China.
FAU - Chen, S-M
AU  - Chen SM
AD  - Section of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung 
      Memorial Hospital, Kaohsiung City, Taiwan, Republic of China. Electronic address: 
      syming99@gmail.com.
FAU - Hang, C-L
AU  - Hang CL
AD  - Section of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung 
      Memorial Hospital, Kaohsiung City, Taiwan, Republic of China; Chang Gung 
      University College of Medicine, Kaohsiung City, Taiwan, Republic of China.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypertension/epidemiology/*etiology
MH  - Liver Transplantation/*methods
MH  - *Living Donors
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - *Postoperative Complications/epidemiology
MH  - Preoperative Period
MH  - Prevalence
MH  - Prospective Studies
MH  - Risk Factors
MH  - Young Adult
EDAT- 2015/03/15 06:00
MHDA- 2015/09/18 06:00
CRDT- 2015/03/15 06:00
PHST- 2014/07/30 00:00 [received]
PHST- 2014/10/10 00:00 [revised]
PHST- 2014/10/28 00:00 [accepted]
PHST- 2015/03/15 06:00 [entrez]
PHST- 2015/03/15 06:00 [pubmed]
PHST- 2015/09/18 06:00 [medline]
AID - S0041-1345(14)01241-X [pii]
AID - 10.1016/j.transproceed.2014.10.050 [doi]
PST - ppublish
SO  - Transplant Proc. 2015 Mar;47(2):445-50. doi: 10.1016/j.transproceed.2014.10.050.