PMID- 25769646
OWN - NLM
STAT- MEDLINE
DCOM- 20160108
LR  - 20220317
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 177
IP  - 1-2
DP  - 2015 May 15
TI  - Cross-protection of a new type 2 porcine reproductive and respiratory syndrome 
      virus (PRRSV) modified live vaccine (Fostera PRRS) against heterologous type 1 
      PRRSV challenge in growing pigs.
PG  - 87-94
LID - S0378-1135(15)00075-9 [pii]
LID - 10.1016/j.vetmic.2015.02.020 [doi]
AB  - The objective of the present study was to determine the cross-protection of a new 
      type 2 porcine reproductive and respiratory syndrome virus (PRRSV) modified live 
      vaccine against heterologous type 1 PRRSV challenge in growing pigs. The mean 
      rectal temperature and respiratory score was significantly (P<0.05) lower in 
      vaccinated challenged pigs than in unvaccinated challenged pigs. Vaccination of 
      pigs with type 2 PRRSV reduced the levels of type 1 PRRSV viremia after challenge 
      with type 1 PRRSV. Vaccinated challenged pigs had significantly (P<0.05) higher 
      frequency of interferon-gamma secreting cells and lower levels of interleukin-10 
      compared to unvaccinated challenged pigs. Vaccination of pigs with the type 2 
      PRRSV effectively reduced the macroscopic and microscopic lung lesion and the 
      type 1 PRRSV antigens within lung lesions in vaccinated challenged pigs. This 
      study demonstrates partial cross-protection of a new type 2 PRRSV modified live 
      vaccine against heterologous type 1 PRRSV challenge in growing pigs.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Park, Changhoon
AU  - Park C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
FAU - Choi, Kyuhyung
AU  - Choi K
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
FAU - Jeong, Jiwoon
AU  - Jeong J
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
FAU - Chae, Chanhee
AU  - Chae C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea. 
      Electronic address: swine@snu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150226
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (Antibodies, Viral)
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Viral Vaccines)
RN  - 130068-27-8 (Interleukin-10)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/immunology
MH  - Cross Protection/*immunology
MH  - Interferon-gamma/immunology
MH  - Interleukin-10/immunology
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology/*prevention & control
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - *Sus scrofa
MH  - Swine
MH  - Vaccination/veterinary
MH  - Vaccines, Attenuated/immunology
MH  - Viral Vaccines/*immunology
MH  - Viremia/immunology
OTO - NOTNLM
OT  - Cross-protection
OT  - Genotype
OT  - Porcine reproductive and respiratory syndrome virus
OT  - Vaccine
EDAT- 2015/03/15 06:00
MHDA- 2016/01/09 06:00
CRDT- 2015/03/15 06:00
PHST- 2015/01/03 00:00 [received]
PHST- 2015/02/15 00:00 [revised]
PHST- 2015/02/17 00:00 [accepted]
PHST- 2015/03/15 06:00 [entrez]
PHST- 2015/03/15 06:00 [pubmed]
PHST- 2016/01/09 06:00 [medline]
AID - S0378-1135(15)00075-9 [pii]
AID - 10.1016/j.vetmic.2015.02.020 [doi]
PST - ppublish
SO  - Vet Microbiol. 2015 May 15;177(1-2):87-94. doi: 10.1016/j.vetmic.2015.02.020. 
      Epub 2015 Feb 26.